Game and Fish finds CWD in new Deer Hunt Area near Sheridan
Wyoming Game & Fish Department sent this bulletin at 11/27/2015 11:00
AM MST
Fall3
Game and Fish finds CWD in new Deer Hunt Area near Sheridan
SHERIDAN - The Wyoming Game and Fish Department recently euthanized a
white-tailed deer exhibiting signs of chronic wasting disease (CWD). The deer
tested positive for CWD, which is a fatal neurological disease of deer, elk and
moose. The white-tailed deer was found in deer hunt area 24 - an area flanked on
three sides by deer hunt areas where CWD was previously documented.
The buck was euthanized by Game and Fish personnel on November 16, 2016
about 2.5 miles southwest of the town of Big Horn.
“We appreciate anyone reporting an animal that appears to be sick and
appreciate the help of the public in monitoring the health of the public’s
wildlife,” Scott Edberg, Deputy Chief of the Wildlife Division, said. Consistent
with the Centers for Disease Control Game and Fish does not recommend people eat
deer, elk or moose that test positive for CWD.
Game and Fish personnel continue to watch for cervids that appear sick.
Game and Fish also continues to collect samples of deer, elk and moose through
hunter field checks and at CWD sampling stations. Game and Fish personnel
collect and analyze more than 1,600 CWD samples annually throughout the state.
Hunters who wish to have their deer, elk or moose tested for CWD outside of
the department’s CWD surveillance program can to do so by contacting the Wyoming
State Veterinary Lab at (307) 766-9925. Hunters should be aware that it may take
a few weeks after their animal is sampled to get their test results.
For more information on chronic wasting disease transmission and
regulations on transportation and disposal of carcasses please visit the Game
and Fish website at:
-WGFD-
Wyoming WGF Commission Meeting 11/6/2015 Afternoon Edition Video
CWD starts at minute 58:51 of first hour of meeting discussion of previous
models predicting extinction of deer population and elk population.
please mark hour 1:02 where remarks were made about potential resistant
genes and prolonged survival, however a recent study (I posted directly next
after youtube link) where it states ;
‘’Our study also demonstrates that mice expressing the deer S96-PRNP
allele, previously shown to be resistant to various cervid prions, are
susceptible to H95+ CWD prions. The potential for the generation of novel
strains raises the possibility of an expanded host range for CWD. ‘’
hour minute mark 1:03
captive Elk study
39 femail elk calves captured on National Elk Refuge In Jackson, WY
Transported to WGFD Thorne-Williams Wildlife Research Unit (Sybille,
TWWRU)
Worst-case scenario for prion exposure
Genotypes
-27 M/M132 (69.2%)
-11 M/L132 (28.2%)
-1 L/L132 (2.6%)
38 of 39 elk died over 10-year study
1 remaining elk was L/L132
still alive and remained negative for PrPCWD by rectal biopsy
Appears healthy, weighs 242kg, and bore healthy calf in May, 2012
CWD infection rate in this study ???
> During the analysis, 37 of 39 elk died, all of which were positive for CWD.
*** Our study also demonstrates that mice expressing the deer S96-PRNP allele, previously shown to be resistant to various cervid prions, are susceptible to H95+ CWD prions. ***
*** Our study also demonstrates that mice expressing the deer S96-PRNP
allele, previously shown to be resistant to various cervid prions, are
susceptible to H95+ CWD prions. ***
*** The potential for the generation of novel strains raises the
possibility of an expanded host range for CWD. ***
UPDATE CWD VACCINE ELK minute mark 1:22:00
VACCINE
RECOMBINANT PROTEIN FUSION VACCINE
Hedlin, PD et al ‘’Design and delivery of a cryptic PrP c epitope for
induction of Prp Sc-specific antibody responses.’’ Vaccine 28.4 (2010)
981-988.
PAN-PROVINCIAL VACCINE ENTERPRISES (PREVENT)
Dose: 2ml IM CWD VACCINE UPDATE IS A FAILURE, I REPEAT, A NEGATIVE RESULTS
FOR CWD VACCINE. .tss
Monday, November 16, 2015
*** Wyoming Latest round of testing CWD surveillance program has found the
disease in three new hunt areas
Saturday, November 14, 2015
Wyoming Chronic Wasting Disease CWD Surveillance Results 2014 reported in
2015
cwd to humans ?
now, let’s see what the authors said about this casual link, personal
communications years ago.
see where it is stated NO STRONG evidence. so, does this mean there IS
casual evidence ????
“Our conclusion stating that we found no strong evidence of CWD
transmission to humans”
From: TSS (216-119-163-189.ipset45.wt.net)
Subject: CWD aka MAD DEER/ELK TO HUMANS ???
Date: September 30, 2002 at 7:06 am PST
From: "Belay, Ermias"
To: Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias"
Sent: Monday, September 30, 2002 9:22 AM
Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Dear Sir/Madam,
In the Archives of Neurology you quoted (the abstract of which was attached
to your email), we did not say CWD in humans will present like variant CJD. That
assumption would be wrong. I encourage you to read the whole article and call me
if you have questions or need more clarification (phone: 404-639-3091). Also, we
do not claim that "no-one has ever been infected with prion disease from eating
venison." Our conclusion stating that we found no strong evidence of CWD
transmission to humans in the article you quoted or in any other forum is
limited to the patients we investigated.
Ermias Belay, M.D. Centers for Disease Control and Prevention
-----Original Message-----
From: Sent: Sunday, September 29, 2002 10:15 AM
To: rr26k@nih.gov; rrace@niaid.nih.gov; ebb8@CDC.GOV
Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS
Thursday, April 03, 2008
A prion disease of cervids: Chronic wasting disease 2008 1: Vet Res. 2008
Apr 3;39(4):41 A prion disease of cervids: Chronic wasting disease Sigurdson CJ.
snip...
*** twenty-seven CJD patients who regularly consumed venison were reported
to the Surveillance Center***,
snip... full text ;
So far, says NIH researcher Race, the two Wisconsin cases pinpointed by the
newspaper look like spontaneous CJD. "But we don't know how CWD would look in
human brains. It probably would look like some garden-variety sporadic CJD."
What the CDC will do with these cases and four others (three from Colorado and
Schwan from Upper Michigan), Race says, is "sequence the prion protein from
these people, inject it into mice and wait to see what the disease looks like in
their brains. That will take two years."
CJD is so rare in people under age 30, one case in a billion (leaving out
medical mishaps), that four cases under 30 is "very high," says Colorado
neurologist Bosque. "Then, if you add these other two from Wisconsin [cases in
the newspaper], six cases of CJD in people associated with venison is very, very
high." Only now, with Mary Riley, there are at least seven, and possibly eight,
with Steve, her dining companion. "It's not critical mass that matters,"
however, Belay says. "One case would do it for me." The chance that two people
who know each other would both contact CJD, like the two Wisconsin sportsmen, is
so unlikely, experts say, it would happen only once in 140 years.
Given the incubation period for TSEs in humans, it may require another
generation to write the final chapter on CWD in Wisconsin. "Does chronic wasting
disease pass into humans? We'll be able to answer that in 2022," says Race.
Meanwhile, the state has become part of an immense experiment.
I urge everyone to watch this video closely...terry
*** you can see video here and interview with Jeff's Mom, and scientist
telling you to test everything and potential risk factors for humans ***
*** These results would seem to suggest that CWD does indeed have zoonotic
potential, at least as judged by the compatibility of CWD prions and their human
PrPC target. Furthermore, extrapolation from this simple in vitro assay suggests
that if zoonotic CWD occurred, it would most likely effect those of the PRNP
codon 129-MM genotype and that the PrPres type would be similar to that found in
the most common subtype of sCJD (MM1).***
*** PRION 2015 CONFERENCE FT. COLLINS CWD RISK FACTORS TO HUMANS ***
*** LATE-BREAKING ABSTRACTS PRION 2015 CONFERENCE ***
O18
Zoonotic Potential of CWD Prions
Liuting Qing1, Ignazio Cali1,2, Jue Yuan1, Shenghai Huang3, Diane Kofskey1,
Pierluigi Gambetti1, Wenquan Zou1, Qingzhong Kong1 1Case Western Reserve
University, Cleveland, Ohio, USA, 2Second University of Naples, Naples, Italy,
3Encore Health Resources, Houston, Texas, USA
***These results indicate that the CWD prion has the potential to infect
human CNS and peripheral lymphoid tissues and that there might be asymptomatic
human carriers of CWD infection.***
P.105: RT-QuIC models trans-species prion transmission
Kristen Davenport, Davin Henderson, Candace Mathiason, and Edward Hoover
Prion Research Center; Colorado State University; Fort Collins, CO USA
Additionally, human rPrP was competent for conversion by CWD and fCWD.
***This insinuates that, at the level of protein:protein interactions, the
barrier preventing transmission of CWD to humans is less robust than previously
estimated.***
From: Terry S. Singeltary Sr.
Sent: Saturday, November 15, 2014 9:29 PM
To: Terry S. Singeltary Sr.
Subject: THE EPIDEMIOLOGY OF CREUTZFELDT-JAKOB DISEASE R. G. WILL 1984
THE EPIDEMIOLOGY OF CREUTZFELDT-JAKOB DISEASE
R. G. WILL
1984
*** The association between venison eating and risk of CJD shows similar
pattern, with regular venison eating associated with a 9 FOLD INCREASE IN RISK
OF CJD (p = 0.04). (SEE LINK IN REPORT HERE...TSS) PLUS, THE CDC DID NOT PUT
THIS WARNING OUT FOR THE WELL BEING OF THE DEER AND ELK ;
snip...
O.05: Transmission of prions to primates after extended silent incubation
periods: Implications for BSE and scrapie risk assessment in human populations
Emmanuel Comoy, Jacqueline Mikol, Val erie Durand, Sophie Luccantoni,
Evelyne Correia, Nathalie Lescoutra, Capucine Dehen, and Jean-Philippe Deslys
Atomic Energy Commission; Fontenay-aux-Roses, France
Prion diseases (PD) are the unique neurodegenerative proteinopathies
reputed to be transmissible under field conditions since decades. The
transmission of Bovine Spongiform Encephalopathy (BSE) to humans evidenced that
an animal PD might be zoonotic under appropriate conditions. Contrarily, in the
absence of obvious (epidemiological or experimental) elements supporting a
transmission or genetic predispositions, PD, like the other proteinopathies, are
reputed to occur spontaneously (atpical animal prion strains, sporadic CJD
summing 80% of human prion cases). Non-human primate models provided the first
evidences supporting the transmissibiity of human prion strains and the zoonotic
potential of BSE. Among them, cynomolgus macaques brought major information for
BSE risk assessment for human health (Chen, 2014), according to their
phylogenetic proximity to humans and extended lifetime. We used this model to
assess the zoonotic potential of other animal PD from bovine, ovine and cervid
origins even after very long silent incubation periods.
*** We recently observed the direct transmission of a natural classical
scrapie isolate to macaque after a 10-year silent incubation period,
***with features similar to some reported for human cases of sporadic CJD,
albeit requiring fourfold longe incubation than BSE. Scrapie, as recently evoked
in humanized mice (Cassard, 2014),
***is the third potentially zoonotic PD (with BSE and L-type BSE),
***thus questioning the origin of human sporadic cases. We will present an
updated panorama of our different transmission studies and discuss the
implications of such extended incubation periods on risk assessment of animal PD
for human health.
===============
***thus questioning the origin of human sporadic cases...TSS
===============
Monday, November 16, 2015
Docket No. APHIS-2007-0127 Scrapie in Sheep and Goats Terry Singeltary Sr.
Submission
Thursday, November 26, 2015
TEXAS CWD TSE PRION REPORTING TURKEY OF THE YEAR AWARD GOES TO SHANNON
TOMPKINS OF THE HOUSTON CHRONICLE
Terry S. Singeltary Sr.
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