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Sunday, July 02, 2017

CFIA Notice to Industry – Updates to the federal management of chronic wasting disease in farmed cervids

Notice to Industry – Updates to the federal management of chronic wasting disease in farmed cervids


June 30, 2017 – Ottawa, ON - The Canadian Food Inspection Agency (CFIA) is updating its national chronic wasting disease (CWD) program to better focus on disease prevention and risk management.

Disease management is a shared responsibility. Efforts to eradicate CWD in the farmed cervid population have not been successful. As a result, the CFIA's new approach aims to reduce the risk of the disease spreading by encouraging producers to adopt strong risk mitigation measures.

As of December 31, 2017, the CFIA's response and compensation will only be provided to producers enrolled in a Voluntary Herd Certification Program (VHCP). A transition period is being provided throughout 2018 to give producers time to enroll in and complete 12 months in a VHCP.

As of January 1, 2019, the CFIA's response and compensation will only apply if the affected producer has been enrolled in and compliant with a VHCP for at least 12 months.

CFIA's response includes movement controls, ordering destruction and disposal of infected herds, and providing compensation to producers.

A VHCP requires enrolled producers to take measures to mitigate the risk of CWD, including ongoing surveillance testing of mature dead cervids and implementation of biosecurity measures.

More information about VHCPs is available in the Accredited Veterinarian's Manual, chapter 13.

Key dates:

June 30, 2017: Announcement of program change to producers, associations and other affected organizations.

December 31, 2017: Implementation of program change. After December 31, 2017, producers need to enroll in a VHCP to be eligible for response and compensation.

January 1, 2018 – December 31, 2018: During this transition period, producers should contact the regional administrator of the VHCP available in their area and consider enrolling in the program in order to control de risk of CWD entering their herd and to be eligible for federal response and compensation.

January 1, 2019: Full implementation of program change. As of January 1, 2019, only producers that have been enrolled in and compliant with a VHCP for at least 12 months will be eligible for CFIA's response and compensation.


Notice to Members Regarding Chronic Wasting Disease (CWD) 

Posted on: May 31st, 2017

 To: MNA Members

From: Métis Nation of Alberta

Date: Wednesday, May 31, 2017

Métis Nation of Alberta (MNA) was made aware of a recent Canadian research study examining the transmission of Chronic Wasting Disease. The initial results of the study indicate that macaque monkeys (genetically similar to humans) can be infected with Chronic Wasting Disease (CWD) after eating deer that is infected with CWD. CWD is a prion disease, which are fatal, transmissible diseases characterized by abnormal proteins in the brain and nervous system. To date no research has shown that CWD can be passed on to humans, and no human cases of CWD have ever been identified. However, this new research indicates that it is a possibility. The Deputy Chief Medical Officer of Health has reached out to us to share with our Métis harvesters this important information. For more information you can visit:


What the Alberta Government knows:

CWD is present in southeastern Alberta, with the area slowly spreading westward over time (introduced into Alberta from Saskatchewan) – see map for more information at http://aep.alberta.ca/fish-wildlife/fishing-hunting-trapping/hunting-alberta/documents/HuntersCWD-HarvestedDeerHeads-2016.pdf

CWD circulates in deer populations, particularly mule deer; it has been found in about 4% of deer tested in 2016;

Elk can be infected in areas where CWD has been present in deer for a long period of time;

Moose can also be infected, but this would be fairly rare.

Necessary Precautions for Harvesters:

Hunters and others who handle carcasses follow basic handling precautions (available here http://aep.alberta.ca/fish-wildlife/fishing-hunting-trapping/hunting-alberta/documents/CWDGuidelines-DeerCarcassTransportationHandling-Oct2009.pdf All deer, moose and elk harvested from CWD mandatory submission wildlife management units (WMUs) be tested for CWD; and A negative result (no CWD detected by the test) must be obtained before any part of an animal is eaten. For more information, contact: Amy Quintal Métis Nation of Alberta Métis Harvesting Liaison Tel: (780) 455 – 2200 aquintal@metis.org


First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress 

Stefanie Czub1, Walter Schulz-Schaeffer2, Christiane Stahl-Hennig3, Michael Beekes4, Hermann Schaetzl5 and Dirk Motzkus6 1 

University of Calgary Faculty of Veterinary Medicine/Canadian Food Inspection Agency; 2Universitatsklinikum des Saarlandes und Medizinische Fakultat der Universitat des Saarlandes; 3 Deutsches Primaten Zentrum/Goettingen; 4 Robert-Koch-Institut Berlin; 5 University of Calgary Faculty of Veterinary Medicine; 6 presently: Boehringer Ingelheim Veterinary Research Center; previously: Deutsches Primaten Zentrum/Goettingen 

This is a progress report of a project which started in 2009. 21 cynomolgus macaques were challenged with characterized CWD material from white-tailed deer (WTD) or elk by intracerebral (ic), oral, and skin exposure routes. Additional blood transfusion experiments are supposed to assess the CWD contamination risk of human blood product. Challenge materials originated from symptomatic cervids for ic, skin scarification and partially per oral routes (WTD brain). Challenge material for feeding of muscle derived from preclinical WTD and from preclinical macaques for blood transfusion experiments. We have confirmed that the CWD challenge material contained at least two different CWD agents (brain material) as well as CWD prions in muscle-associated nerves. 

Here we present first data on a group of animals either challenged ic with steel wires or per orally and sacrificed with incubation times ranging from 4.5 to 6.9 years at postmortem. Three animals displayed signs of mild clinical disease, including anxiety, apathy, ataxia and/or tremor. In four animals wasting was observed, two of those had confirmed diabetes. All animals have variable signs of prion neuropathology in spinal cords and brains and by supersensitive IHC, reaction was detected in spinal cord segments of all animals. Protein misfolding cyclic amplification (PMCA), real-time quaking-induced conversion (RT-QuiC) and PET-blot assays to further substantiate these findings are on the way, as well as bioassays in bank voles and transgenic mice. 

At present, a total of 10 animals are sacrificed and read-outs are ongoing. Preclinical incubation of the remaining macaques covers a range from 6.4 to 7.10 years. Based on the species barrier and an incubation time of > 5 years for BSE in macaques and about 10 years for scrapie in macaques, we expected an onset of clinical disease beyond 6 years post inoculation. 

PRION 2017 DECIPHERING NEURODEGENERATIVE DISORDERS 

 Subject: PRION 2017 CONFERENCE DECIPHERING NEURODEGENERATIVE DISORDERS VIDEO

PRION 2017 CONFERENCE DECIPHERING NEURODEGENERATIVE DISORDERS

PRION 2017 CONFERENCE VIDEO



Chronic Wasting Disease CWD TSE Prion to Humans, who makes that final call, when, or, has it already happened?

TUESDAY, JUNE 13, 2017

PRION 2017 CONFERENCE ABSTRACT First evidence of intracranial and peroral transmission of Chronic Wasting Disease (CWD) into Cynomolgus macaques: a work in progress


SURVEILLANCE DATA - CHRONIC WASTING DISEASE

BACKGROUND

Chronic wasting disease (CWD) is a disease of the brain of deer, elk and moose which is similar to BSE (mad cow disease) in cattle and scrapie in sheep. It was introduced into farmed elk in Saskatchewan from infected elk imported from the US in the late 1980s, and has since spread to wild white-tailed deer, mule deer and elk populations in several locations within Saskatchewan and Alberta. The disease is caused by infectious proteins, called prions, which can be transmitted by animal-to-animal contact or by contact with environments contaminated with these infectious agents. Infected animals become weak and emaciated and tend to drink large amounts of water and salivate excessively. CWD is invariably fatal and could have severe impacts of deer populations throughout North America. It appears unlikely the disease can be transmitted to humans and most domestic animals but the full host range of CWD is unknown.

WHAT WE ARE DOING

Beginning in 1997, the Saskatchewan Ministry of Environment (MOE) and the CWHC started a CWD surveillance program for wild deer, elk and moose. This surveillance program was based primarily on the testing of hunter-killed animals and to a lesser extent on the testing of sick or dead cervids. The program ended in 2012 with over 45 000 heads tested and a total of 387 positives from 20 Wildlife Management Zones (WMZs) (see map). The CWHC continues to test cervids that are submitted through our diagnostic program and we have continued to diagnose CWD in new areas. Starting in 2006 the CWHC embarked on a research program in Saskatchewan with the aid of PrioNet and the MOE to look at factors affecting the spread of CWD. Phase I of the project focused on direct and indirect contact rates, habitat selection, long distance movements and survival trends as they relate to CWD. Phase II which began in 2009 focused on direct observations of mule deer and their use of environmental sites to determine risk of infection by CWD.


Chronic Wasting Disease Testing in Saskatchewan


 2015 CWD Status
SpeciesNegativePositiveInconclusiveTotal
Elk140115
Moose241126
Mule Deer80200100
White-Tailed Deer854190
Total203253231

*Includes both hunter surveillance and diagnostic samples





earMule DeerWhite-tailed DeerElkMooseTotal
PosNegPosNegPosNegPosNegPosNeg
19971030360000039
1998109101802000111
19991079057044000180
2000111840726089001999
2001 Spring1115405800001212
2001 Fall010770223603400003653
2002 Spring113402400001158
2002 Fall732442241301630095820
2003 Fall22283001922015300224905
2004 Fall305265214390900326713
2005 Fall22526351093804704353624
2006 Fall22723432214970164010494014
2007 Fall232256113172929004474384
2008 Fall243366858281214027494737
2009 Fall23422193378071020372688
2010 Fall2317924552051018351413
2011 Fall227401541915201933891
2012 Fall226247720933601436506
2013313402102081335
20143131761724072145
TOTAL33327949791551591572013042145126

Notes:

This table does not include those specimens which were deemed unsuitable for testing.

1From 1997 until the fall of 2000, only the brain section (obex) was used to diagnosis CWD. Starting in 2001, tonsils and/or retropharyngeal lymph nodes were also examined.

2Starting in the fall of 2005 animals under 1 year of age were no longer tested under the program because detectable infection is rare in a young animal and therefore not cost effective in terms of surveillance.

3The hunter surveillance program was discontinued in 2012 and the 2013 and 2014 numbers are from diagnostic samples.


Ontario, Canada


Chronic Wasting Disease Surveillance Program 2015 to 2016 Program Update Wildlife Research and Monitoring Section


Short Communication

High prevalence of prion protein genotype associated with resistance to chronic wasting disease in one Alberta woodland caribou population

Yo Ching Cheng, Marco Musiani, Maria Cavedon & Sabine Gilch

Page 00 | Received 31 Jan 2017, Accepted 23 Feb 2017, Accepted author version posted online: 28 Mar 2017


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Translator disclaimer

 Accepted author version

Abstract

Chronic wasting disease (CWD) is a prion disease found in deer, elk and moose in North America and since recently, wild reindeer in Norway. Caribou are at-risk to encounter CWD in areas such as Alberta, Canada, where the disease spreads towards caribou habitats. CWD susceptibility is modulated by species-specific polymorphisms in the prion protein gene (Prnp). We sequenced Prnp of woodland caribou from nine Albertan populations. In one population (Chinchaga) a significantly higher frequency of the 138N allele linked to reduced CWD susceptibility was observed. These data are relevant for developing CWD management strategies including conservation of threatened caribou populations.

Keywords: Chronic wasting disease, caribou, prion protein, prion protein gene polymorphism, genetic resistance, conservation

Disclaimer

As a service to authors and researchers we are providing this version of an accepted manuscript (AM). Copyediting, typesetting, and review of the resulting proofs will be undertaken on this manuscript before final publication of the Version of Record (VoR). During production and pre-press, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal relate to these versions also.


cwd resistant cervid??? 

***at present, no cervid PrP allele conferring absolute resistance to prion infection has been identified. 

P-145 Estimating chronic wasting disease resistance in cervids using real time quaking- induced conversion 

Nicholas J Haley1, Rachel Rielinqer2, Kristen A Davenport3, W. David Walter4, Katherine I O'Rourke5, Gordon Mitchell6, Juergen A Richt2 1 Department of Microbiology and Immunology, Midwestern University, United States; 2Department of Diagnostic Medicine and Pathobiology, Kansas State University; 3Prion Research Center; Colorado State University; 4U.S. Geological Survey, Pennsylvania Cooperative Fish and Wildlife Research Unit; 5Agricultural Research Service, United States Department of Agriculture; 6Canadian Food Inspection Agency, National and OlE Reference Laboratory for Scrapie and CWD 

In mammalian species, the susceptibility to prion diseases is affected, in part, by the sequence of the host's prion protein (PrP). In sheep, a gradation from scrapie susceptible to resistant has been established both in vivo and in vitro based on the amino acids present at PrP positions 136, 154, and 171, which has led to global breeding programs to reduce the prevalence of scrapie in domestic sheep. In cervids, resistance is commonly characterized as a delayed progression of chronic wasting disease (CWD); at present, no cervid PrP allele conferring absolute resistance to prion infection has been identified. To model the susceptibility of various naturally-occurring and hypothetical cervid PrP alleles in vitro, we compared the amplification rates and efficiency of various CWD isolates in recombinant PrPC using real time quaking-induced conversion. We hypothesized that amplification metrics of these isolates in cervid PrP substrates would correlate to in vivo susceptibility - allowing susceptibility prediction for alleles found at 10 frequency in nature, and that there would be an additive effect of multiple resistant codons in hypothetical alleles. Our studies demonstrate that in vitro amplification metrics predict in vivo susceptibility, and that alleles with multiple codons, each influencing resistance independently, do not necessarily contribute additively to resistance. Importantly, we found that the white-tailed deer 226K substrate exhibited the slowest amplification rate among those evaluated, suggesting that further investigation of this allele and its resistance in vivo are warranted to determine if absolute resistance to CWD is possible. 

***at present, no cervid PrP allele conferring absolute resistance to prion infection has been identified. 

PRION 2016 CONFERENCE TOKYO 

http://www.tandfonline.com/doi/pdf/10.1080/19336896.2016.1162644?needAccess=true

Saturday, May 28, 2016 

*** Infection and detection of PrPCWD in soil from CWD infected farm in Korea Prion 2016 Tokyo *** 


http://chronic-wasting-disease.blogspot.com/2016/05/infection-and-detection-of-prpcwd-in.html

Subject: Iowa DNR issues statement on Iowa Supreme Court Ruling

This is very, very concerning imo. 

IF this ruling is upheld as such ;

''The Iowa Supreme Court upheld the district court ruling — saying the law gives the DNR only the authority to quarantine the deer — not the land. The ruling says if the Iowa Legislature wants to expand the quarantine powers as suggested by the DNR, then it is free to do so.''

IF a 'precedent' is set as such, by the Legislature not intervening to expand quarantine powers to the DNR for CWD TSE Prion, and the precedent is set as such that the cervid industry and land there from, once contaminated with the CWD TSE Prion, are free to repopulate, sell the land, etc, imo, this will blow the lid off any containment efforts of this damn disease CWD TSE Prion. The Iowa Supreme Court did not just pass the cwd buck down the road, the Supreme Court of Iowa just threw the whole state of Iowa under the bus at 100 MPH. this makes no sense to me, if this is set in stone and the Legislation does not stop it, and stop if fast, any containment of the cwd tse prion will be futile, imo...terry

*** 2016 -2017 UPDATED SCIENCE ON CHRONIC WASTING DISEASE CWD TSE PRION ***

SATURDAY, JUNE 17, 2017

Iowa DNR issues statement on Iowa Supreme Court Ruling


TUESDAY, JUNE 06, 2017

CHRONIC WASTING DISEASE CWD TSE PRION ZOONOSIS ZOONOTIC INSIDIOUS AND DIRE CONSEQUENCES AHEAD 


FRIDAY, JUNE 02, 2017

Alberta Canada Chronic Wasting Disease (CWD) Surveillance Update: 2016/17 Final


MONDAY, MARCH 13, 2017

Herds infected with Chronic Wasting Disease in Canada – 2017


Friday, September 02, 2016

Canada Chronic Wasting Disease CWD Surveillance Update 2016


Subject: PRION 2017 CONFERENCE DECIPHERING NEURODEGENERATIVE DISORDERS VIDEO

thought everyone would like/should watch this...kind regards, terry

Subject: PRION 2017 CONFERENCE DECIPHERING NEURODEGENERATIVE DISORDERS VIDEO

PRION 2017 CONFERENCE DECIPHERING NEURODEGENERATIVE DISORDERS

PRION 2017 CONFERENCE VIDEO



Thursday, June 29, 2017 

PRION 2017 CONFERENCE DECIPHERING NEURODEGENERATIVE DISORDERS VIDEO

http://prionprp.blogspot.com/2017/06/prion-2017-conference-deciphering.html


THURSDAY, JUNE 22, 2017 

PRION 2017 CONFERENCE P120 Early preclinical detection of prions in blood of macaques peripherally infected with the variant CJD agent


MONDAY, JUNE 19, 2017 

PRION 2017 CONFERENCE ABSTRACT P61 vCJD strain properties in a Spanish mother and son replicate as those of a young UK case


MONDAY, JUNE 19, 2017 

PRION 2017 P20 Descriptive epidemiology of human prion diseases in Japan: a prospective 16-year surveillance study

Japan Prion Disease Increasing Annually to 2.3 patients per 1 million populations in 2014


FRIDAY, JUNE 16, 2017

PRION 2017 P55 Susceptibility of human prion protein to in vitro conversion by chronic wasting disease prions


TUESDAY, JUNE 13, 2017

PRION 2017 CONFERENCE ABSTRACT Chronic Wasting Disease in European moose is associated with PrPSc features different from North American CWD


SATURDAY, JUNE 10, 2017

Chronic Wasting Disease CWD TSE Prion to Humans, who makes that final call, when, or, has it already happened?


WEDNESDAY, JUNE 21, 2017 

Docket No. FDA– 2009–N–0505 Agency Information Collection Activities; Proposed Collection; Recordkeeping and Reporting Requirements for Human Food and Cosmetics Manufactured From, Processed With, or Otherwise Containing Material From Cattle


THURSDAY, JUNE 22, 2017 

World Organisation for Animal Health (OIE) to establish liaison office in College Station, Texas


MONDAY, MAY 29, 2017 

Canada CCA optimistic over potential for revisions to OIE criteria for BSE negligible risk


MONDAY, JUNE 19, 2017 

Transmissible Spongiform Encephalopathies Advisory Committee June 2017 CJD, BSE, Scrapie, CWD, TSE, Prion?


THURSDAY, JUNE 22, 2017 

National Prion Disease Pathology Surveillance Center Cases Examined(1) (May 18, 2017)


SPONTANEOUS ATYPICAL BOVINE SPONGIFORM ENCEPHALOPATHY

***Moreover, sporadic disease has never been observed in breeding colonies or primate research laboratories, most notably among hundreds of animals over several decades of study at the National Institutes of Health25, and in nearly twenty older animals continuously housed in our own facility.***


Terry S. Singeltary Sr.

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