THREE DECATUR COUNTY DEER CONFIRMED POSITIVE FOR CHRONIC WASTING DISEASE KANSAS
Saturday, January 19, 2008 THREE DECATUR COUNTY DEER CONFIRMED POSITIVE FOR CHRONIC WASTING DISEASE KANSAS
THREE DECATUR COUNTY DEER CONFIRMED POSITIVE FOR CHRONIC WASTING DISEASE
CWD contingency plan includes further sampling
PRATT--Three white-tailed deer taken by hunters in Decatur County have tested positive for chronic wasting disease (CWD), according to the Kansas Department of Wildlife and Parks.
Dr. Ruby Mosher, KDWP’s wildlife disease coordinator, said the initial screening tests performed by Kansas State Veterinary Diagnostic Laboratory have been confirmed by the National Veterinary Services Laboratory in Ames, Iowa. All three deer were taken by hunters along Sappa Creek in central Decatur County, north of Oberlin, which is in the northwest corner of the state. Testing is still to be completed on approximately two-thirds of the samples collected by KDWP for testing. The samples from northwestern Kansas are given priority since they are from deer that have a higher known risk of being exposed to CWD than those in the rest of the state. As results are returned over the next 6 to 8 weeks, regular updates will be posted on the KDWP website here.
CWD has been detected twice previously in Kansas. The first case was in 2001 in a captive elk herd in Harper County. The other occurred during the 2005 hunting season in a wild whitetail doe harvested in Cheyenne County.
Last month, the Nebraska Game and Parks Commission reported a CWD-positive deer from an area just a few miles north of Decatur County, in Red Willow County, Nebraska.
Wildlife biologists from Kansas and Nebraska plan to sample more deer in the vicinity in February to help determine the prevalence of the disease in the area.
Tissue samples from more than 2,200 deer taken by hunters during the most recent Kansas hunting season have been submitted for lab analysis. The three affected deer from Decatur County were among those samples, and the hunters who shot those deer have been notified.
KDWP biologists have conducted annual sampling of hunter-harvested and road-killed deer since 1996. Although research is underway, there is currently no vaccine or other biological method of preventing CWD. The only tool is to prevent the spread of CWD to new areas, because once the infective particle (an abnormal prion) is deposited into the environment -- either through an infected carcass or from a live animal -- it may exist for a decade or more, capable of infecting a healthy deer. Despite the recent occurrences, the likelihood of finding CWD in a wild deer harvested in Kansas is small. That small likelihood decreases even more the farther from northwestern Kansas the deer lived. In recent years, numerous cases of CWD have been documented in neighboring areas of Colorado, Nebraska and Wyoming.
While CWD is fatal to infected deer and elk, humans have never been known to contract the disease. CWD is a member of the group of diseases called transmissible spongiform encephalopathies (TSEs). Other diseases in this group include scrapie in sheep and goats, bovine spongiform encephalopathy (BSE or mad cow disease) in cattle, and Cruetzfeldt-Jacob disease in people. CWD is a progressive, fatal disease that results in small holes developing in the brain, giving it a sponge-like appearance under the microscope. Decreased brain function causes the animal to display neurological symptoms such as depression, droopy head, staggering, loss of appetite, and a lack of response to man. The continuing deterioration of the brain leads to other symptoms such as weight loss, drooling, and excessive thirst. Caution is advised because of unknown factors associated with prion diseases, but no human health risks have been discovered where CWD occurs.
The symptoms of CWD include loss of body weight, stumbling, holding the head at an odd angle, circling, non-responsiveness to people, and pneumonia. Any sick deer or elk should be reported it to the nearest KDWP office or the Emporia Research Office, 620-342-0658. Hunters can help protect the health of the Kansas deer herd by taking the following steps to avoid accidentally introducing CWD to a new area in Kansa s: • do not transport deer carcasses far from the area where the deer lived, especially from areas where CWD has been detected, such as northwestern Kansas; and • if a carcass is transported, the hunter should make sure that carcass waste is not dumped into the environment where local deer or elk can come into contact with it. Carcass waste can be disposed of by double-bagging it and taking it to a landfill.
The Chronic Wasting Disease Alliance maintains an online clearinghouse of information about the disease ( www.cwd-info.org). More information is also available on the KDWP website (enter “CWD” in the search box at the KDWP website: www.kdwp.state.ks.us). Contact Bob Mathews at KDWP’s Pratt office (620/672-5911) for more information.
http://www.kdwp.state.ks.us/news/hunting/three_decatur_county_deer_confirmed_positive_for_chronic_wasting_disease
http://www.kdwp.state.ks.us/news/content/pdf/18941
3 Decatur County deer found to have fatal disease
BY MICHAEL PEARCE The Wichita Eagle
http://www.kansas.com/news/state/story/285844.html
Though similar to Creutzfeldt-Jakob disease, which reportedly killed a man from the Colby area this week, chronic wasting has yet to be passed to livestock or humans. ...
PLEASE note, this statement is in line with the same BSe that was stated about the death of a man recently from 'suspected' sporadic Creutzfeldt Jakob Disease in the Colby area. Chronic Wasting Disease in deer and elk i.e. CWD, is a TSE Transmissible Spongiform Encephalopathy, same as BSE or Bovine Spongiform Encephalopathy in cattle (oh, and sheep and goats too, yes BSE has tranasmitted to both). IT really gets confusing, but our friendly federal officials (industry reps) love to play down all this as if it never has, and never will, sadly, it already has. i urge all of you to READ THE SCIENCE AND TRANSMISSION STUDIES TO DATE. CWD has transmitted to cattle and primates, transmission studies have never been done on man.
MY comment about the recent 'suspect' case of sporadic CJD in the Colby area, and please remember this one thing about the infamous sporadic CJD's ;
there is 26790 hits on 'sporadic' at pub-med.
there is 12830 hits on 'sporadic disease' at pub-med.
with the first few being ;
Comparison Analysis of Gene Expression Patterns between Sporadic Alzheimer's and Parkinson's Disease.
http://www.ncbi.nlm.nih.gov/pubmed/18198416?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Sporadic ALS with early onset respiratory failure is not associated with IGHMBP2 gene mutations.
http://www.ncbi.nlm.nih.gov/pubmed/18187479?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Sporadic Multiple Cerebral Cavernomatosis: Report of a Case and Review of Literature
http://www.ncbi.nlm.nih.gov/pubmed/18195658?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
A sporadic disease is one that occurs only occasionally in a population (i.e., prevalence is zero).
http://mansfield.osu.edu/~sabedon/biol2045.htm
sporadic CJD is NOT a single strain.
sporadic CJD is simply a human TSE, which route and source is unknown. ...
Date: 2008-01-17T19:37:31
IN reply to 'a real health threat'.
I can assure you both are a real health threat. my mother died from the Heidenhain Variant of CJD 'confirmed', and i damn near died from the MRSA, after refusing blood and cadaver bone. go figure. but this case of CJD in question, it could very well have been caused by the USA strain of mad cow disease i.e. BASE, of which the last two case in the USA were. IF anyone would take the time to read the science, the USA mad cow strain i.e. BASE is more like some sub-types of sporadic CJD, NOT the UK nvCJD. Plus, in 2007 alone, 5 cases of the atypical scrapie NOR-98 were documented in 5 different states in the USA, again, this strain of scrapie i.e. the NOR-98 closely resembles that of sporadic CJD, of which is increasing here in the USA. SO, to catigorically state that this case is not related to mad cow, is not accurate. they simply don't know. could be from many TSE sources here in the USA. ...
see full text and references ;
http://pod01.prospero.com/n/pfx/forum.aspx?tsn=22&nav=display&webtag=kr-kansastm&tid=19673
P01.47
Quantifying the Species Barrier in Chronic Wasting Disease by a Novel in vitro Conversion Assay
Li, L1; Coulthart, MB2; Balachandran, A3; Chakrabartty, A4; Cashman, NR1 1University of British Columbia, Brain Research Centre, Canada; 2Public Health Agency of Canada, National Microbiology Laboratory, Canada; 3Animal Diseases Research Institute, Canada Food Inspection Agency, National Reference Laboratory for Scrapie and CWD, Canada; 4Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Canada
Background: Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy that can affect North American cervids (deer, elk, and moose). Although the risk of CWD crossing the species barrier and causing human disease is still unknown, however, definite bovine spongiform encephalopathy (BSE) transmission to humans as variant CJD (vCJD), it would seem prudent to limit the exposure of humans to CWD.
Aim: In view of the fact that BSE can be readily transmitted to non-bovid species, it is important to establish the species susceptibility range of CWD.
Methods: In vitro conversion system was performed by incubation of prions with normal brain homogenates as described before, and protease K (PK) resistant PrP was determined by immunoblotting with 6H4 monoclonal prion antibody.
Results: Our results demonstrate that PrPC from cervids (including moose) can be efficiently converted to a protease-resistant form by incubation with elk CWD prions, presumably due to sequence and structural similarities between these species. Interestingly, hamster shows a high conversion ratio by PrPCWD. Moreover, partial denaturation of substrate PrPC can apparently overcome the structural barriers between more distant species.
Conclusions: Our work correctly predicted the transmission of CWD to a wild moose. We find a species barrier for prion protein conversion between cervids and other species, however, this barrier might be overcome if the PrPC substrate has been partially denatured in a cellular environment. Such an environment might also promote CWD transmission to non-cervid species, *** including humans. Acid/GdnHCl-treated brain PrPC was a superior substrate for the in vitro conversion than PrPC treated at physiological pH. This has implications for the process by which the prion protein is converted in disease.
http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf
Epidemiologic studies have also been initiated to identify human cases of prion disease among persons with an increased risk for exposure to potentially CWD-infected deer or elk meat (47). If such cases are identified, laboratory data showing similarities of the etiologic agent to that of the CWD agent would strengthen the conclusion for a causal link. Surveillance for human prion diseases, particularly in areas where CWD has been detected, remains important to effectively monitor the possible transmission of CWD to humans. Because of the long incubation period associated with prion diseases, convincing negative results from epidemiologic and experimental laboratory studies would likely require years of follow-up. In the meantime, to minimize the risk for exposure to the CWD agent, hunters should consult with their state wildlife agencies to identify areas where CWD occurs and continue to follow advice provided by public health and wildlife agencies. Hunters should avoid eating meat from deer and elk that look sick or test positive for CWD. They should wear gloves when field-dressing carcasses, bone-out the meat from the animal, and minimize handling of brain and spinal cord tissues. As a precaution, hunters should avoid eating deer and elk tissues known to harbor the CWD agent (e.g., brain, spinal cord, eyes, spleen, tonsils, lymph nodes) from areas where CWD has been identified.
http://www.cdc.gov/ncidod/EID/vol10no6/03-1082.htm
From: TSS (216-119-163-189.ipset45.wt.net) Subject: CWD aka MAD DEER/ELK TO HUMANS ??? Date: September 30, 2002 at 7:06 am PST
From: "Belay, Ermias" To: Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias" Sent: Monday, September 30, 2002 9:22 AM Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Dear Sir/Madam, In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD.
That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.
Ermias Belay, M.D. Centers for Disease Control and Prevention
-----Original Message----- From: Sent: Sunday, September 29, 2002 10:15 AM To: [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask] Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS
also,
A. Aguzzi - Chronic Wasting Disease (CWD) also needs to be addressed. Most serious because of rapid horizontal spread and higher prevalence than BSE in UK, up to 15% in some populations. Also may be a risk to humans - evidence that it is not dangerous to humans is thin.
http://www.tseandfoodsafety.org/activities/bse_conference_basel_april_02/2summary_of_conference.htm
JOURNAL OURNAL OF VIROLOGY IROLOGY, Nov. 2005, p. 13794–13796 Vol. 79, No. 21 0022-538X/05/$08.00 !0 doi:10.1128/JVI.79.21.13794–13796.2005 Copyright © 2005, American Society for Microbiology. All Rights Reserved.
NOTES
Interspecies Transmission of Chronic Wasting Disease Prions to Squirrel Monkeys (Saimiri sciureus sciureus)
http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0704&L=sanet-mg&T=0&P=1165
From: "Terry S. Singeltary Sr."Subject: CWD UPDATE 88 AUGUST 31, 2007
http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0709&L=sanet-mg&T=0&P=450
Date: Wed, 29 Aug 2007 21:13:08 -0500From: "Terry S. Singeltary Sr." Subject: CWD NEW MEXICO RECORDS IT'S 19 CASE (near Texas border again)
http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-mg&T=0&P=26079
Subject: Monitoring the Potential Transmission of Chronic Wasting Disease to Humans Using a Hunter Registry Database in Wyoming Date: August 30, 2007 at 6:46 pm PST
http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-mg&T=0&P=27654
PLEASE NOTE IN USA CJD UPDATE AS AT JUNE 2007, please note steady increasein ''TYPE UNKNOWN''. ...TSS
1 Acquired in the United Kingdom; 2 Acquired in Saudi Arabia; 3 Includes 17inconclusive and 9 pending (1 from 2006, 8from 2007); 4 Includes 17 non-vCJD type unknown (2 from 1996, 2 from 1997, 1from 2001, 1 from 2003, 4 from 2004, 3from 2005, 4 from 2006) and 36 type pending (2 from 2005, 8 from 2006,
*** 26 from 2007)
http://www.cjdsurveillance.com/pdf/case-table.pdf
http://pro-med.blogspot.com/2007/11/proahedr-prion-disease-update-2007-07.html
http://chronic-wasting-disease.blogspot.com/
Monday, January 07, 2008 CWD Update 89 January 4, 2008
http://chronic-wasting-disease.blogspot.com/2008/01/cwd-update-89-january-4-2008.html
Wednesday, December 12, 2007 SEAC 99th meeting on Friday 14th December 2007
16 January 2008 - The final minutes of the 98th SEAC meeting have been published.
PUBLIC QUESTION AND ANSWER SESSION 2
© SEAC 2007
SEAC considered a question about possible links between CJD cases and animal TSEs in the United States of America (USA).
http://www.seac.gov.uk/summaries/seac99_summary.pdf
SEAC 99th meeting on Friday 14th December 2007
http://seac992007.blogspot.com/
Friday, January 11, 2008
CJD HUMAN TSE REPORT UK, USA, CANADA, and Mexico JANUARY 2008
http://cjdmadcowbaseoct2007.blogspot.com/2008/01/cjd-human-tse-report-uk-usa-canada-and.html
Saturday, January 12, 2008
Prominent and Persistent Extraneural Infection in Human PrP Transgenic Mice Infected with Variant CJD
http://cjdmadcowbaseoct2007.blogspot.com/2008/01/prominent-and-persistent-extraneural.html
ANIMAL HEALTH REPORT 2006 (BSE h-BASE ALABAMA)
http://animalhealthreport2006.blogspot.com/
BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA, A REVIEW OF SORTS
http://madcowtesting.blogspot.com/
MADCOW USDA the untold story
http://madcowusda.blogspot.com/
BSE OIE USDA
http://madcowtesting.blogspot.com/2008/01/bse-oie-usda.html
CREUTZFELDT JAKOB DISEASE MAD COW BASE UPDATE USA
http://cjdmadcowbaseoct2007.blogspot.com/
SCRAPIE USA
http://scrapie-usa.blogspot.com/
NOR-98 ATYPICAL SCRAPIE CASES USA
http://nor-98.blogspot.com/
Transmissible Mink Encephalopathy TME
http://transmissible-mink-encephalopathy.blogspot.com/
CHRONIC WASTING DISEASE
http://chronic-wasting-disease.blogspot.com/
Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States
http://cjdusa.blogspot.com/
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
TSEAC MEETINGS
http://tseac.blogspot.com/
I only ponder how many sporadic CJDs in the USA are type 2 PrPSc?
http://www.neurology.org/cgi/eletters/60/2/176#535
THE PATHOLOGICAL PROTEIN
Hardcover, 304 pages plus photos and illustrations. ISBN 0-387-95508-9 June 2003
BY Philip Yam
CHAPTER 14 LAYING ODDS
Answering critics like Terry Singeltary, who feels that the U.S. under-counts CJD, Schonberger conceded that the current surveillance system has errors but stated that most of the errors will be confined to the older population.
http://www.thepathologicalprotein.com/
doi:10.1016/S1473-3099(03)00715-1Copyright © 2003 Published by Elsevier Ltd.
Newsdesk
Tracking spongiform encephalopathies in North America
Xavier Bosch
Available online 29 July 2003. Volume 3, Issue 8, August 2003, Page 463
"My name is Terry S Singeltary Sr, and I live in Bacliff, Texas. I lost my mom to hvCJD (Heidenhain variant CJD) and have been searching for answers ever since. What I have found is that we have not been told the truth. CWD in deer and elk is a small portion of a much bigger problem." ...
http://www.thelancet.com/journals/laninf/article/PIIS1473309903007151/fulltext
http://download.thelancet.com/pdfs/journals/1473-3099/PIIS1473309903007151.pdf
Diagnosis and Reporting of Creutzfeldt-Jakob Disease
Singeltary, Sr et al. JAMA.2001; 285: 733-734.
http://jama.ama-assn.org/http://www.neurology.org/cgi/eletters/60/2/176#535
Like lambs to the slaughter 31 March 2001 Debora MacKenzie Magazine issue 2284
FOUR years ago, Terry Singeltary watched his mother die horribly from a degenerative brain disease. Doctors told him it was Alzheimer's, but Singeltary was suspicious. The diagnosis didn't fit her violent symptoms, and he demanded an autopsy. It showed she had died of sporadic Creutzfeldt-Jakob disease. Most doctors believe that sCJD is caused by a prion protein deforming by chance into a killer. But Singeltary thinks otherwise. He is one of a number of campaigners who say that some sCJD, like the variant CJD related to BSE, is caused by eating meat from infected animals. Their suspicions have focused on sheep carrying scrapie, a BSE-like disease that is wide spread in flocks across Europe and North America. Now scientists in France have stumbled across new evidence that adds weight to the campaigners' fears. To their complete surprise, the researchers found that one strain of scrapie causes the same brain damage in mice as sCJD. "This means we cannot rule out that at least some sCJD may be caused by some strains of scrapie," says team member Jean-Philippe Deslys of the French Atomic Energy Commission's medical research laboratory in Fontenay-aux-Roses, south-west of Paris. Hans Kretschmar of the University of Göttingen, who coordinates CJD surveillance in Germany, is so concerned by the findings that he now wants to trawl back through past sCJD cases to see if any might have been caused by eating infected mutton or lamb. ...
http://www.newscientist.com/article/mg16922840.300-like-lambs-to-the-slaughter.html
DER SPIEGEL (9/2001) - 24.02.2001 (9397 Zeichen)USA: Loch in der MauerDie BSE-Angst erreicht Amerika: Trotz strikter Auflagen gelangte in Texasverbotenes Tiermehl ins Rinderfutter - die Kontrollen der Aufsichtsbehördensind lax. Link auf diesen Artikel im Archiv: http://service.spiegel.de/digas/find?DID=18578755"
Its as full of holes as Swiss Cheese" says Terry Singeltary of the FDA regulations. ...
http://service.spiegel.de/digas/servlet/find/DID=18578755
Thu Dec 6, 2007 11:38
FDA IN CRISIS MODE, AMERICAN LIVES AT RISK
http://www.cidrap.umn.edu/cidrap/content/fs/food-disease/news/dec0407fda.html
FDA SCIENCE AND MISSION AT RISK
http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4329b_02_01_FDA%20Report%20on%20Science%20and%20Technology.pdf
2 January 2000 British Medical Journal
U.S. Scientist should be concerned with a CJD epidemic in the U.S., as well
http://www.bmj.com/cgi/eletters/320/7226/8/b#6117
15 November 1999 British Medical Journal
vCJD in the USA * BSE in U.S.
http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406
BSE (Mad Cow) Update: Do Reports of sCJD Clusters Matter?
snip... see full text ;
http://cjdtexas.blogspot.com/
Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518
THREE DECATUR COUNTY DEER CONFIRMED POSITIVE FOR CHRONIC WASTING DISEASE
CWD contingency plan includes further sampling
PRATT--Three white-tailed deer taken by hunters in Decatur County have tested positive for chronic wasting disease (CWD), according to the Kansas Department of Wildlife and Parks.
Dr. Ruby Mosher, KDWP’s wildlife disease coordinator, said the initial screening tests performed by Kansas State Veterinary Diagnostic Laboratory have been confirmed by the National Veterinary Services Laboratory in Ames, Iowa. All three deer were taken by hunters along Sappa Creek in central Decatur County, north of Oberlin, which is in the northwest corner of the state. Testing is still to be completed on approximately two-thirds of the samples collected by KDWP for testing. The samples from northwestern Kansas are given priority since they are from deer that have a higher known risk of being exposed to CWD than those in the rest of the state. As results are returned over the next 6 to 8 weeks, regular updates will be posted on the KDWP website here.
CWD has been detected twice previously in Kansas. The first case was in 2001 in a captive elk herd in Harper County. The other occurred during the 2005 hunting season in a wild whitetail doe harvested in Cheyenne County.
Last month, the Nebraska Game and Parks Commission reported a CWD-positive deer from an area just a few miles north of Decatur County, in Red Willow County, Nebraska.
Wildlife biologists from Kansas and Nebraska plan to sample more deer in the vicinity in February to help determine the prevalence of the disease in the area.
Tissue samples from more than 2,200 deer taken by hunters during the most recent Kansas hunting season have been submitted for lab analysis. The three affected deer from Decatur County were among those samples, and the hunters who shot those deer have been notified.
KDWP biologists have conducted annual sampling of hunter-harvested and road-killed deer since 1996. Although research is underway, there is currently no vaccine or other biological method of preventing CWD. The only tool is to prevent the spread of CWD to new areas, because once the infective particle (an abnormal prion) is deposited into the environment -- either through an infected carcass or from a live animal -- it may exist for a decade or more, capable of infecting a healthy deer. Despite the recent occurrences, the likelihood of finding CWD in a wild deer harvested in Kansas is small. That small likelihood decreases even more the farther from northwestern Kansas the deer lived. In recent years, numerous cases of CWD have been documented in neighboring areas of Colorado, Nebraska and Wyoming.
While CWD is fatal to infected deer and elk, humans have never been known to contract the disease. CWD is a member of the group of diseases called transmissible spongiform encephalopathies (TSEs). Other diseases in this group include scrapie in sheep and goats, bovine spongiform encephalopathy (BSE or mad cow disease) in cattle, and Cruetzfeldt-Jacob disease in people. CWD is a progressive, fatal disease that results in small holes developing in the brain, giving it a sponge-like appearance under the microscope. Decreased brain function causes the animal to display neurological symptoms such as depression, droopy head, staggering, loss of appetite, and a lack of response to man. The continuing deterioration of the brain leads to other symptoms such as weight loss, drooling, and excessive thirst. Caution is advised because of unknown factors associated with prion diseases, but no human health risks have been discovered where CWD occurs.
The symptoms of CWD include loss of body weight, stumbling, holding the head at an odd angle, circling, non-responsiveness to people, and pneumonia. Any sick deer or elk should be reported it to the nearest KDWP office or the Emporia Research Office, 620-342-0658. Hunters can help protect the health of the Kansas deer herd by taking the following steps to avoid accidentally introducing CWD to a new area in Kansa s: • do not transport deer carcasses far from the area where the deer lived, especially from areas where CWD has been detected, such as northwestern Kansas; and • if a carcass is transported, the hunter should make sure that carcass waste is not dumped into the environment where local deer or elk can come into contact with it. Carcass waste can be disposed of by double-bagging it and taking it to a landfill.
The Chronic Wasting Disease Alliance maintains an online clearinghouse of information about the disease ( www.cwd-info.org). More information is also available on the KDWP website (enter “CWD” in the search box at the KDWP website: www.kdwp.state.ks.us). Contact Bob Mathews at KDWP’s Pratt office (620/672-5911) for more information.
http://www.kdwp.state.ks.us/news/hunting/three_decatur_county_deer_confirmed_positive_for_chronic_wasting_disease
http://www.kdwp.state.ks.us/news/content/pdf/18941
3 Decatur County deer found to have fatal disease
BY MICHAEL PEARCE The Wichita Eagle
http://www.kansas.com/news/state/story/285844.html
Though similar to Creutzfeldt-Jakob disease, which reportedly killed a man from the Colby area this week, chronic wasting has yet to be passed to livestock or humans. ...
PLEASE note, this statement is in line with the same BSe that was stated about the death of a man recently from 'suspected' sporadic Creutzfeldt Jakob Disease in the Colby area. Chronic Wasting Disease in deer and elk i.e. CWD, is a TSE Transmissible Spongiform Encephalopathy, same as BSE or Bovine Spongiform Encephalopathy in cattle (oh, and sheep and goats too, yes BSE has tranasmitted to both). IT really gets confusing, but our friendly federal officials (industry reps) love to play down all this as if it never has, and never will, sadly, it already has. i urge all of you to READ THE SCIENCE AND TRANSMISSION STUDIES TO DATE. CWD has transmitted to cattle and primates, transmission studies have never been done on man.
MY comment about the recent 'suspect' case of sporadic CJD in the Colby area, and please remember this one thing about the infamous sporadic CJD's ;
there is 26790 hits on 'sporadic' at pub-med.
there is 12830 hits on 'sporadic disease' at pub-med.
with the first few being ;
Comparison Analysis of Gene Expression Patterns between Sporadic Alzheimer's and Parkinson's Disease.
http://www.ncbi.nlm.nih.gov/pubmed/18198416?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Sporadic ALS with early onset respiratory failure is not associated with IGHMBP2 gene mutations.
http://www.ncbi.nlm.nih.gov/pubmed/18187479?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
Sporadic Multiple Cerebral Cavernomatosis: Report of a Case and Review of Literature
http://www.ncbi.nlm.nih.gov/pubmed/18195658?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
A sporadic disease is one that occurs only occasionally in a population (i.e., prevalence is zero).
http://mansfield.osu.edu/~sabedon/biol2045.htm
sporadic CJD is NOT a single strain.
sporadic CJD is simply a human TSE, which route and source is unknown. ...
Date: 2008-01-17T19:37:31
IN reply to 'a real health threat'.
I can assure you both are a real health threat. my mother died from the Heidenhain Variant of CJD 'confirmed', and i damn near died from the MRSA, after refusing blood and cadaver bone. go figure. but this case of CJD in question, it could very well have been caused by the USA strain of mad cow disease i.e. BASE, of which the last two case in the USA were. IF anyone would take the time to read the science, the USA mad cow strain i.e. BASE is more like some sub-types of sporadic CJD, NOT the UK nvCJD. Plus, in 2007 alone, 5 cases of the atypical scrapie NOR-98 were documented in 5 different states in the USA, again, this strain of scrapie i.e. the NOR-98 closely resembles that of sporadic CJD, of which is increasing here in the USA. SO, to catigorically state that this case is not related to mad cow, is not accurate. they simply don't know. could be from many TSE sources here in the USA. ...
see full text and references ;
http://pod01.prospero.com/n/pfx/forum.aspx?tsn=22&nav=display&webtag=kr-kansastm&tid=19673
P01.47
Quantifying the Species Barrier in Chronic Wasting Disease by a Novel in vitro Conversion Assay
Li, L1; Coulthart, MB2; Balachandran, A3; Chakrabartty, A4; Cashman, NR1 1University of British Columbia, Brain Research Centre, Canada; 2Public Health Agency of Canada, National Microbiology Laboratory, Canada; 3Animal Diseases Research Institute, Canada Food Inspection Agency, National Reference Laboratory for Scrapie and CWD, Canada; 4Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Canada
Background: Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy that can affect North American cervids (deer, elk, and moose). Although the risk of CWD crossing the species barrier and causing human disease is still unknown, however, definite bovine spongiform encephalopathy (BSE) transmission to humans as variant CJD (vCJD), it would seem prudent to limit the exposure of humans to CWD.
Aim: In view of the fact that BSE can be readily transmitted to non-bovid species, it is important to establish the species susceptibility range of CWD.
Methods: In vitro conversion system was performed by incubation of prions with normal brain homogenates as described before, and protease K (PK) resistant PrP was determined by immunoblotting with 6H4 monoclonal prion antibody.
Results: Our results demonstrate that PrPC from cervids (including moose) can be efficiently converted to a protease-resistant form by incubation with elk CWD prions, presumably due to sequence and structural similarities between these species. Interestingly, hamster shows a high conversion ratio by PrPCWD. Moreover, partial denaturation of substrate PrPC can apparently overcome the structural barriers between more distant species.
Conclusions: Our work correctly predicted the transmission of CWD to a wild moose. We find a species barrier for prion protein conversion between cervids and other species, however, this barrier might be overcome if the PrPC substrate has been partially denatured in a cellular environment. Such an environment might also promote CWD transmission to non-cervid species, *** including humans. Acid/GdnHCl-treated brain PrPC was a superior substrate for the in vitro conversion than PrPC treated at physiological pH. This has implications for the process by which the prion protein is converted in disease.
http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf
Epidemiologic studies have also been initiated to identify human cases of prion disease among persons with an increased risk for exposure to potentially CWD-infected deer or elk meat (47). If such cases are identified, laboratory data showing similarities of the etiologic agent to that of the CWD agent would strengthen the conclusion for a causal link. Surveillance for human prion diseases, particularly in areas where CWD has been detected, remains important to effectively monitor the possible transmission of CWD to humans. Because of the long incubation period associated with prion diseases, convincing negative results from epidemiologic and experimental laboratory studies would likely require years of follow-up. In the meantime, to minimize the risk for exposure to the CWD agent, hunters should consult with their state wildlife agencies to identify areas where CWD occurs and continue to follow advice provided by public health and wildlife agencies. Hunters should avoid eating meat from deer and elk that look sick or test positive for CWD. They should wear gloves when field-dressing carcasses, bone-out the meat from the animal, and minimize handling of brain and spinal cord tissues. As a precaution, hunters should avoid eating deer and elk tissues known to harbor the CWD agent (e.g., brain, spinal cord, eyes, spleen, tonsils, lymph nodes) from areas where CWD has been identified.
http://www.cdc.gov/ncidod/EID/vol10no6/03-1082.htm
From: TSS (216-119-163-189.ipset45.wt.net) Subject: CWD aka MAD DEER/ELK TO HUMANS ??? Date: September 30, 2002 at 7:06 am PST
From: "Belay, Ermias" To: Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias" Sent: Monday, September 30, 2002 9:22 AM Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Dear Sir/Madam, In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD.
That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.
Ermias Belay, M.D. Centers for Disease Control and Prevention
-----Original Message----- From: Sent: Sunday, September 29, 2002 10:15 AM To: [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask] Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS
also,
A. Aguzzi - Chronic Wasting Disease (CWD) also needs to be addressed. Most serious because of rapid horizontal spread and higher prevalence than BSE in UK, up to 15% in some populations. Also may be a risk to humans - evidence that it is not dangerous to humans is thin.
http://www.tseandfoodsafety.org/activities/bse_conference_basel_april_02/2summary_of_conference.htm
JOURNAL OURNAL OF VIROLOGY IROLOGY, Nov. 2005, p. 13794–13796 Vol. 79, No. 21 0022-538X/05/$08.00 !0 doi:10.1128/JVI.79.21.13794–13796.2005 Copyright © 2005, American Society for Microbiology. All Rights Reserved.
NOTES
Interspecies Transmission of Chronic Wasting Disease Prions to Squirrel Monkeys (Saimiri sciureus sciureus)
http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0704&L=sanet-mg&T=0&P=1165
From: "Terry S. Singeltary Sr."Subject: CWD UPDATE 88 AUGUST 31, 2007
http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0709&L=sanet-mg&T=0&P=450
Date: Wed, 29 Aug 2007 21:13:08 -0500From: "Terry S. Singeltary Sr." Subject: CWD NEW MEXICO RECORDS IT'S 19 CASE (near Texas border again)
http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-mg&T=0&P=26079
Subject: Monitoring the Potential Transmission of Chronic Wasting Disease to Humans Using a Hunter Registry Database in Wyoming Date: August 30, 2007 at 6:46 pm PST
http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-mg&T=0&P=27654
PLEASE NOTE IN USA CJD UPDATE AS AT JUNE 2007, please note steady increasein ''TYPE UNKNOWN''. ...TSS
1 Acquired in the United Kingdom; 2 Acquired in Saudi Arabia; 3 Includes 17inconclusive and 9 pending (1 from 2006, 8from 2007); 4 Includes 17 non-vCJD type unknown (2 from 1996, 2 from 1997, 1from 2001, 1 from 2003, 4 from 2004, 3from 2005, 4 from 2006) and 36 type pending (2 from 2005, 8 from 2006,
*** 26 from 2007)
http://www.cjdsurveillance.com/pdf/case-table.pdf
http://pro-med.blogspot.com/2007/11/proahedr-prion-disease-update-2007-07.html
http://chronic-wasting-disease.blogspot.com/
Monday, January 07, 2008 CWD Update 89 January 4, 2008
http://chronic-wasting-disease.blogspot.com/2008/01/cwd-update-89-january-4-2008.html
Wednesday, December 12, 2007 SEAC 99th meeting on Friday 14th December 2007
16 January 2008 - The final minutes of the 98th SEAC meeting have been published.
PUBLIC QUESTION AND ANSWER SESSION 2
© SEAC 2007
SEAC considered a question about possible links between CJD cases and animal TSEs in the United States of America (USA).
http://www.seac.gov.uk/summaries/seac99_summary.pdf
SEAC 99th meeting on Friday 14th December 2007
http://seac992007.blogspot.com/
Friday, January 11, 2008
CJD HUMAN TSE REPORT UK, USA, CANADA, and Mexico JANUARY 2008
http://cjdmadcowbaseoct2007.blogspot.com/2008/01/cjd-human-tse-report-uk-usa-canada-and.html
Saturday, January 12, 2008
Prominent and Persistent Extraneural Infection in Human PrP Transgenic Mice Infected with Variant CJD
http://cjdmadcowbaseoct2007.blogspot.com/2008/01/prominent-and-persistent-extraneural.html
ANIMAL HEALTH REPORT 2006 (BSE h-BASE ALABAMA)
http://animalhealthreport2006.blogspot.com/
BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA, A REVIEW OF SORTS
http://madcowtesting.blogspot.com/
MADCOW USDA the untold story
http://madcowusda.blogspot.com/
BSE OIE USDA
http://madcowtesting.blogspot.com/2008/01/bse-oie-usda.html
CREUTZFELDT JAKOB DISEASE MAD COW BASE UPDATE USA
http://cjdmadcowbaseoct2007.blogspot.com/
SCRAPIE USA
http://scrapie-usa.blogspot.com/
NOR-98 ATYPICAL SCRAPIE CASES USA
http://nor-98.blogspot.com/
Transmissible Mink Encephalopathy TME
http://transmissible-mink-encephalopathy.blogspot.com/
CHRONIC WASTING DISEASE
http://chronic-wasting-disease.blogspot.com/
Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States
http://cjdusa.blogspot.com/
CJD QUESTIONNAIRE
http://cjdquestionnaire.blogspot.com/
TSEAC MEETINGS
http://tseac.blogspot.com/
I only ponder how many sporadic CJDs in the USA are type 2 PrPSc?
http://www.neurology.org/cgi/eletters/60/2/176#535
THE PATHOLOGICAL PROTEIN
Hardcover, 304 pages plus photos and illustrations. ISBN 0-387-95508-9 June 2003
BY Philip Yam
CHAPTER 14 LAYING ODDS
Answering critics like Terry Singeltary, who feels that the U.S. under-counts CJD, Schonberger conceded that the current surveillance system has errors but stated that most of the errors will be confined to the older population.
http://www.thepathologicalprotein.com/
doi:10.1016/S1473-3099(03)00715-1Copyright © 2003 Published by Elsevier Ltd.
Newsdesk
Tracking spongiform encephalopathies in North America
Xavier Bosch
Available online 29 July 2003. Volume 3, Issue 8, August 2003, Page 463
"My name is Terry S Singeltary Sr, and I live in Bacliff, Texas. I lost my mom to hvCJD (Heidenhain variant CJD) and have been searching for answers ever since. What I have found is that we have not been told the truth. CWD in deer and elk is a small portion of a much bigger problem." ...
http://www.thelancet.com/journals/laninf/article/PIIS1473309903007151/fulltext
http://download.thelancet.com/pdfs/journals/1473-3099/PIIS1473309903007151.pdf
Diagnosis and Reporting of Creutzfeldt-Jakob Disease
Singeltary, Sr et al. JAMA.2001; 285: 733-734.
http://jama.ama-assn.org/http://www.neurology.org/cgi/eletters/60/2/176#535
Like lambs to the slaughter 31 March 2001 Debora MacKenzie Magazine issue 2284
FOUR years ago, Terry Singeltary watched his mother die horribly from a degenerative brain disease. Doctors told him it was Alzheimer's, but Singeltary was suspicious. The diagnosis didn't fit her violent symptoms, and he demanded an autopsy. It showed she had died of sporadic Creutzfeldt-Jakob disease. Most doctors believe that sCJD is caused by a prion protein deforming by chance into a killer. But Singeltary thinks otherwise. He is one of a number of campaigners who say that some sCJD, like the variant CJD related to BSE, is caused by eating meat from infected animals. Their suspicions have focused on sheep carrying scrapie, a BSE-like disease that is wide spread in flocks across Europe and North America. Now scientists in France have stumbled across new evidence that adds weight to the campaigners' fears. To their complete surprise, the researchers found that one strain of scrapie causes the same brain damage in mice as sCJD. "This means we cannot rule out that at least some sCJD may be caused by some strains of scrapie," says team member Jean-Philippe Deslys of the French Atomic Energy Commission's medical research laboratory in Fontenay-aux-Roses, south-west of Paris. Hans Kretschmar of the University of Göttingen, who coordinates CJD surveillance in Germany, is so concerned by the findings that he now wants to trawl back through past sCJD cases to see if any might have been caused by eating infected mutton or lamb. ...
http://www.newscientist.com/article/mg16922840.300-like-lambs-to-the-slaughter.html
DER SPIEGEL (9/2001) - 24.02.2001 (9397 Zeichen)USA: Loch in der MauerDie BSE-Angst erreicht Amerika: Trotz strikter Auflagen gelangte in Texasverbotenes Tiermehl ins Rinderfutter - die Kontrollen der Aufsichtsbehördensind lax. Link auf diesen Artikel im Archiv: http://service.spiegel.de/digas/find?DID=18578755"
Its as full of holes as Swiss Cheese" says Terry Singeltary of the FDA regulations. ...
http://service.spiegel.de/digas/servlet/find/DID=18578755
Thu Dec 6, 2007 11:38
FDA IN CRISIS MODE, AMERICAN LIVES AT RISK
http://www.cidrap.umn.edu/cidrap/content/fs/food-disease/news/dec0407fda.html
FDA SCIENCE AND MISSION AT RISK
http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4329b_02_01_FDA%20Report%20on%20Science%20and%20Technology.pdf
2 January 2000 British Medical Journal
U.S. Scientist should be concerned with a CJD epidemic in the U.S., as well
http://www.bmj.com/cgi/eletters/320/7226/8/b#6117
15 November 1999 British Medical Journal
vCJD in the USA * BSE in U.S.
http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406
BSE (Mad Cow) Update: Do Reports of sCJD Clusters Matter?
snip... see full text ;
http://cjdtexas.blogspot.com/
Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518
posted by Terry S. Singeltary Sr. at
11:15 AM
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