Wednesday, November 18, 2015

TEXAS Mule Deer Outlook Promising; Hunters Reminded of Mandatory CWD Testing

News Release Media Contact: Steve Lightfoot, 512-389-4701, steve.lightfoot@tpwd.texas.gov

 
Nov. 17, 2015

 
Mule Deer Outlook Promising; Hunters Reminded of Mandatory CWD Testing

 
AUSTIN – Prospects are good for the upcoming mule deer hunting season, which gets under way Saturday, Nov. 21 in the Texas Panhandle and Nov. 27 in the Trans Pecos. Texas Parks and Wildlife Department biologists say above average habitat conditions have bolstered body weights and antler growth this year. Also, the state agency is asking hunters and landowners to submit harvested mule deer for sampling as part of enhanced, statewide monitoring efforts for Chronic Wasting Disease.

 
Although not required in the Panhandle, mule deer harvested in far West Texas are required to be submitted for testing under TPWD’s Chronic Wasting Disease Management Plan protocols. The plan includes mandatory check stations for susceptible species like elk and mule deer taken inside the CWD Containment Zone, which covers portions of Hudspeth, Culberson, and El Paso counties. See a Texas CWD zones map on the department’s website.

 
The Texas Animal Health Commission and TPWD will also use the CWD check stations in a cooperative effort to monitor for bovine tuberculosis (TB) in Texas. The tissue samples used for this effort would be the same samples currently collected as part of the ongoing CWD monitoring effort.

 
Hunters taking mule deer inside the Containment Zone during the 2015-16 mule deer hunting season are required to submit their harvest (unfrozen head) for CWD sampling at a check station within 24 hours of take. Over 800 tissue samples have been collected for CWD testing purposes from hunter-harvested deer and elk from the Trans Pecos ecoregion the past three hunting seasons, and CWD has not been detected in mule deer located outside of the Hueco Mountain area.

 
“We recommend hunters in the Containment Zone and High Risk Zone quarter deer in the field and leave all but the quarters, backstraps, and head at the site of harvest if they are unable to bury the inedible carcass parts as deep as possible on the ranch or take them to a landfill,” said Shawn Gray, Mule Deer Program Leader for TPWD.

 
Mandatory check stations will be open from 9 a.m. to 9 p.m. Nov. 27 – Dec. 13 and 9 a.m. to 7 p.m. on Dec 14. Stations will be located in Cornudas at May’s Café (on US 62-180) and in Van Horn at the Van Horn Convention Center (1801 West Broadway).

 
Hunters who harvest deer in the Containment Zone outside the general season under the authority of MLDP (Managed Lands Deer Permits) will need to call TPWD at (512) 221-8491 the day the deer is harvested to make arrangements to have the deer sampled for CWD.

 
Deer and elk harvested in other areas of the Trans Pecos and Panhandle regions may present their deer for CWD testing, to aid in statewide surveillance effort to contain the disease. A voluntary check station will be established at the Hip-O Taxidermy in Alpine (east side of town on US 90, across from Dairy Queen) during the first three weekends of the general season, Saturday through Monday (Nov. 28–30, Dec. 5–7, and Dec. 12–14), from 9 a.m. – 5 p.m. Saturday and Sunday and 9 a.m. – 1 p.m. Monday. Other check station locations are illustrated on a map shown on TPWD’s main CWD web page.

 
All deer brought to the check stations this season will be aged as part of disease surveillance. Additional biological information such as antler measurements and field dressed weights will also be collected as time allows.

 
SL 2015-11-17

 
http://tpwd.texas.gov/newsmedia/releases/?req=20151117b

 

Wednesday, March 18, 2015

 
*** Chronic Wasting Disease CWD Confirmed Texas Trans Pecos March 18, 2015 8 CASES DOCUMENTED IN WILD IN THAT AREA TO DATE

 
http://chronic-wasting-disease.blogspot.com/2015/03/chronic-wasting-disease-cwd-confirmed.html

 

Saturday, November 14, 2015

 
TEXAS CAPTIVE BREEDER CHRONIC WASTING DISEASE CWD 2 MORE SUSPECTS DECTECTED BRINGING NUMBER TO 7 DETECTED IN CAPTIVE BREEDER (if/when the last two are confirmed).

 
http://chronic-wasting-disease.blogspot.com/2015/11/texas-captive-breeder-chronic-wasting.html

 

Monday, November 16, 2015

 
TEXAS PARKS AND WILDLIFE DEPARTMENT EXECUTIVE DIRECTOR ORDER NO. 015-006 Chronic Wasting Disease (CWD) immediate danger to the white-tailed deer and mule deer resources of Texas

 
http://chronic-wasting-disease.blogspot.com/2015/11/texas-parks-and-wildlife-department.html

 

Thursday, September 24, 2015

 
TEXAS Hunters Asked to Submit Samples for Chronic Wasting Disease CWD TSE Prion Testing

 
*** I cannot stress enough to all of you, for the sake of your family and mine, before putting anything in the freezer, have those deer tested for CWD. ...terry

 
http://chronic-wasting-disease.blogspot.com/2015/09/texas-hunters-asked-to-submit-samples.html

 

Saturday, October 03, 2015

 
TEXAS CHRONIC WASTING DISEASE CWD TSE PRION GOD MUST NOT BE A TEXAN 2002 TO 2015

 
http://chronic-wasting-disease.blogspot.com/2015/10/texas-chronic-wasting-disease-cwd-tse.html

 

Wednesday, March 25, 2015

 
*** Chronic Wasting Disease CWD Cases Confirmed In New Mexico 2013 and 2014 UPDATE 2015

 
http://chronic-wasting-disease.blogspot.com/2015/03/chronic-wasting-disease-cwd-cases.html

 

Wyoming WGF Commission Meeting 11/6/2015 Afternoon Edition Video

 
CWD starts at minute 58:51 of first hour of meeting discussion of previous models predicting extinction of deer population and elk population.

 
please mark hour 1:02 where remarks were made about potential resistant genes and prolonged survival, however a recent study (I posted directly next after youtube link) where it states ;

 
‘’Our study also demonstrates that mice expressing the deer S96-PRNP allele, previously shown to be resistant to various cervid prions, are susceptible to H95+ CWD prions. The potential for the generation of novel strains raises the possibility of an expanded host range for CWD. ‘’

 
hour minute mark 1:03

 
captive Elk study

 
39 femail elk calves captured on National Elk Refuge In Jackson, WY

 
Transported to WGFD Thorne-Williams Wildlife Research Unit (Sybille, TWWRU)

 
Worst-case scenario for prion exposure

 
Genotypes

 
-27 M/M132 (69.2%)

 
-11 M/L132 (28.2%)

 
-1 L/L132 (2.6%)

 
38 of 39 elk died over 10-year study

 
1 remaining elk was L/L132

 
still alive and remained negative for PrPCWD by rectal biopsy

 
Appears healthy, weighs 242kg, and bore healthy calf in May, 2012

 
CWD infection rate in this study ???

 
https://www.youtube.com/watch?v=bnlk4kW3fFw

 
> During the analysis, 37 of 39 elk died, all of which were positive for CWD.

 
http://www.esajournals.org/doi/pdf/10.1890/ES14-00013.1

 
*** Our study also demonstrates that mice expressing the deer S96-PRNP allele, previously shown to be resistant to various cervid prions, are susceptible to H95+ CWD prions. ***

 
*** The potential for the generation of novel strains raises the possibility of an expanded host range for CWD. ***

 
Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic Wasting Disease Strains

 
Camilo Duque Velásqueza,b, Chiye Kima,c, Allen Herbsta,b, Nathalie Daudea,d, Maria Carmen Garzaa,e, Holger Willea,e, Judd Aikena,b and Debbie McKenziea,c aCentre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada bDepartment of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada cDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada dDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada eDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

 
B. Caughey, Editor

 
+ Author Affiliations

 
ABSTRACT

 
Transmission of chronic wasting disease (CWD) between cervids is influenced by the primary structure of the host cellular prion protein (PrPC). In white-tailed deer, PRNP alleles encode the polymorphisms Q95 G96 (wild type [wt]), Q95 S96 (referred to as the S96 allele), and H95 G96 (referred to as the H95 allele), which differentially impact CWD progression. We hypothesize that the transmission of CWD prions between deer expressing different allotypes of PrPC modifies the contagious agent affecting disease spread. To evaluate the transmission properties of CWD prions derived experimentally from deer of four PRNP genotypes (wt/wt, S96/wt, H95/wt, or H95/S96), transgenic (tg) mice expressing the wt allele (tg33) or S96 allele (tg60) were challenged with these prion agents. Passage of deer CWD prions into tg33 mice resulted in 100% attack rates, with the CWD H95/S96 prions having significantly longer incubation periods. The disease signs and neuropathological and protease-resistant prion protein (PrP-res) profiles in infected tg33 mice were similar between groups, indicating that a prion strain (Wisc-1) common to all CWD inocula was amplified. In contrast, tg60 mice developed prion disease only when inoculated with the H95/wt and H95/S96 CWD allotypes. Serial passage in tg60 mice resulted in adaptation of a novel CWD strain (H95+) with distinct biological properties. Transmission of first-passage tg60CWD-H95+ isolates into tg33 mice, however, elicited two prion disease presentations consistent with a mixture of strains associated with different PrP-res glycotypes. Our data indicate that H95-PRNP heterozygous deer accumulated two CWD strains whose emergence was dictated by the PrPC primary structure of the recipient host. These findings suggest that CWD transmission between cervids expressing distinct PrPC molecules results in the generation of novel CWD strains.

 
IMPORTANCE CWD prions are contagious among wild and captive cervids in North America and in South Korea. We present data linking the amino acid variant Q95H in white-tailed deer cellular prion protein (PrPC) to the emergence of a novel CWD strain (H95+). We show that, upon infection, deer expressing H95-PrPC molecules accumulated a mixture of CWD strains that selectively propagated depending on the PRNP genotype of the host in which they were passaged. Our study also demonstrates that mice expressing the deer S96-PRNP allele, previously shown to be resistant to various cervid prions, are susceptible to H95+ CWD prions. The potential for the generation of novel strains raises the possibility of an expanded host range for CWD.

 


 
*** Our study also demonstrates that mice expressing the deer S96-PRNP allele, previously shown to be resistant to various cervid prions, are susceptible to H95+ CWD prions. ***

 
*** The potential for the generation of novel strains raises the possibility of an expanded host range for CWD. ***

 
UPDATE CWD VACCINE ELK minute mark 1:22:00

 
VACCINE

 
RECOMBINANT PROTEIN FUSION VACCINE

 
Hedlin, PD et al ‘’Design and delivery of a cryptic PrP c epitope for induction of Prp Sc-specific antibody responses.’’ Vaccine 28.4 (2010) 981-988.

 
PAN-PROVINCIAL VACCINE ENTERPRISES (PREVENT)

 
Dose: 2ml IM CWD VACCINE UPDATE IS A FAILURE, I REPEAT, A NEGATIVE RESULTS FOR CWD VACCINE. .tss

 
https://www.youtube.com/watch?v=bnlk4kW3fFw

 
Monday, November 16, 2015

 
*** Wyoming Latest round of testing CWD surveillance program has found the disease in three new hunt areas

 
http://chronic-wasting-disease.blogspot.com/2015/11/wyoming-latest-round-of-testing-cwd.html

 
P.97: Scrapie transmits to white-tailed deer by the oral route and has a molecular profile similar to chronic wasting disease and distinct from the scrapie inoculum

 
Justin Greenlee1, S Jo Moore1, Jodi Smith1, M Heather West Greenlee2, and Robert Kunkle1 1National Animal Disease Center; Ames, IA USA; 2Iowa State University; Ames, IA USA

 
The purpose of this work was to determine susceptibility of white-tailed deer (WTD) to the agent of sheep scrapie and to compare the resultant PrPSc to that of the original inoculum and chronic wasting disease (CWD). We inoculated WTD by a natural route of exposure (concurrent oral and intranasal (IN); n D 5) with a US scrapie isolate. All scrapie-inoculated deer had evidence of PrPSc accumulation. PrPSc was detected in lymphoid tissues at preclinical time points, and deer necropsied after 28 months post-inoculation had clinical signs, spongiform encephalopathy, and widespread distribution of PrPSc in neural and lymphoid tissues. Western blotting (WB) revealed PrPSc with 2 distinct molecular profiles. WB on cerebral cortex had a profile similar to the original scrapie inoculum, whereas WB of brainstem, cerebellum, or lymph nodes revealed PrPSc with a higher profile resembling CWD. Homogenates with the 2 distinct profiles from WTD with clinical scrapie were further passaged to mice expressing cervid prion protein and intranasally to sheep and WTD. In cervidized mice, the 2 inocula have distinct incubation times. Sheep inoculated intranasally with WTD derived scrapie developed disease, but only after inoculation with the inoculum that had a scrapie-like profile. The WTD study is ongoing, but deer in both inoculation groups are positive for PrPSc by rectal mucosal biopsy. In summary, this work demonstrates that WTD are susceptible to the agent of scrapie, 2 distinct molecular profiles of PrPSc are present in the tissues of affected deer, and inoculum of either profile readily passes to deer.

 
https://prion2015.files.wordpress.com/2015/05/prion2015abstracts.pdf

 
Saturday, January 31, 2015

 
European red deer (Cervus elaphus elaphus) are susceptible to Bovine Spongiform Encephalopathy BSE by Oral Alimentary route

 
http://transmissiblespongiformencephalopathy.blogspot.com/2015/01/european-red-deer-cervus-elaphus.html

 
I strenuously once again urge the FDA and its industry constituents, to make it MANDATORY that all ruminant feed be banned to all ruminants, and this should include all cervids as soon as possible for the following reasons...

 
======

 
In the USA, under the Food and Drug Administrations BSE Feed Regulation (21 CFR 589.2000) most material (exceptions include milk, tallow, and gelatin) from deer and elk is prohibited for use in feed for ruminant animals. With regards to feed for non-ruminant animals, under FDA law, CWD positive deer may not be used for any animal feed or feed ingredients. For elk and deer considered at high risk for CWD, the FDA recommends that these animals do not enter the animal feed system.

 
***However, this recommendation is guidance and not a requirement by law.

 
======

 
31 Jan 2015 at 20:14 GMT

 
*** Ruminant feed ban for cervids in the United States? ***

 
31 Jan 2015 at 20:14 GMT

 
http://www.plosone.org/annotation/listThread.action?root=85351


Monday, October 26, 2015

 
*** FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED VIOLATIONS OFFICIAL ACTION INDICATED OIA UPDATE October 2015 ***

 
http://madcowusda.blogspot.com/2015/10/fda-part-589-substances-prohibited-from.html

 
Sunday, October 25, 2015

 
*** USAHA Detailed Events Schedule – 119th USAHA Annual Meeting CAPTIVE LIVESTOCK CWD SCRAPIE TSE PRION ***

 
http://chronic-wasting-disease.blogspot.com/2015/10/usaha-detailed-events-schedule-119th.html

 
Docket No. APHIS-2007-0127 Scrapie in Sheep and Goats Terry Singeltary Sr. Submission

 
Docket No. APHIS-2007-0127 Scrapie in Sheep and Goats

 
SUMMARY: We are reopening the comment period for our proposed rule that would revise completely the scrapie regulations, which concern the risk groups and categories established for individual animals and for flocks, the use of genetic testing as a means of assigning risk levels to animals, movement restrictions for animals found to be genetically less susceptible or resistant to scrapie, and recordkeeping requirements. This action will allow interested persons additional time to prepare and submit comments.DATES: The comment period for the proposed rule published on September 10, 2015 (80 FR 54660-54692) is reopened. We will consider all comments that we receive on or before December 9, 2015. ...

 
http://www.regulations.gov/#!documentDetail;D=APHIS-2007-0127-0001

 
http://www.gpo.gov/fdsys/pkg/FR-2015-11-16/html/2015-29179.htm

 
http://www.regulations.gov/#!docketDetail;D=APHIS-2007-0127

 

COMMENT SUBMISSION TERRY S. SINGELTARY SR.

 

WITH regards to Docket No. APHIS-2007-0127 Scrapie in Sheep and Goats, I kindly submit the following ;

 

>>>The last major revision of the scrapie regulations occurred on August 21, 2001, when we published in theFederal Register(66 FR 43964, Docket No. 97-093-5) a final rule amending part 79 by imposing additional restrictions on the interstate movement of sheep and goats.<<<

 

Indeed, much science has changed about the Scrapie TSE prion, including more science linking Scrapie to humans. sadly, politics, industry, and trade, have not changed, and those usually trump sound science, as is the case with all Transmissible Spongiform Encephalopathy TSE Prion disease in livestock producing animals and the OIE. we can look no further at the legal trading of the Scrapie TSE prion both typical and atypical of all strains, and CWD all stains. With as much science of old, and now more new science to back this up, Scrapie of all types i.e. atypical and typical, BSE all strains, and CWD all strains, should be regulated in trade as BSE TSE PRION. In fact, I urge APHIS et al and the OIE, and all trading partners to take heed to the latest science on the TSE prion disease, all of them, and seriously reconsider the blatant disregards for human and animal health, all in the name of trade, with the continued relaxing of TSE Prion trade regulations through the ‘NEGLIGIBLE BSE RISK’ PROGRAM, which was set up to fail in the first place. If the world does not go back to the ‘BSE RISK ASSESSMENTS’, enhance, and or change that assessment process to include all TSE prion disease, i.e. ‘TSE RISK ASSESSMENT’, if we do not do this and if we continue this farce with OIE and the USDA et al, and the ‘NEGLIGIBLE BSE RISK’ PROGRAM, we will never eradicate the TSE prion aka mad cow type disease, they will continue to mutate and spread among species of human and animal origin, and they will continue to kill. ...

 

please see ;

 

O.05: Transmission of prions to primates after extended silent incubation periods: Implications for BSE and scrapie risk assessment in human populations

 

Emmanuel Comoy, Jacqueline Mikol, Val erie Durand, Sophie Luccantoni, Evelyne Correia, Nathalie Lescoutra, Capucine Dehen, and Jean-Philippe Deslys Atomic Energy Commission; Fontenay-aux-Roses, France

 

Prion diseases (PD) are the unique neurodegenerative proteinopathies reputed to be transmissible under field conditions since decades. The transmission of Bovine Spongiform Encephalopathy (BSE) to humans evidenced that an animal PD might be zoonotic under appropriate conditions. Contrarily, in the absence of obvious (epidemiological or experimental) elements supporting a transmission or genetic predispositions, PD, like the other proteinopathies, are reputed to occur spontaneously (atpical animal prion strains, sporadic CJD summing 80% of human prion cases). Non-human primate models provided the first evidences supporting the transmissibiity of human prion strains and the zoonotic potential of BSE. Among them, cynomolgus macaques brought major information for BSE risk assessment for human health (Chen, 2014), according to their phylogenetic proximity to humans and extended lifetime. We used this model to assess the zoonotic potential of other animal PD from bovine, ovine and cervid origins even after very long silent incubation periods.

 

*** We recently observed the direct transmission of a natural classical scrapie isolate to macaque after a 10-year silent incubation period,

 

***with features similar to some reported for human cases of sporadic CJD, albeit requiring fourfold longe incubation than BSE. Scrapie, as recently evoked in humanized mice (Cassard, 2014),

 

***is the third potentially zoonotic PD (with BSE and L-type BSE),

 

***thus questioning the origin of human sporadic cases. We will present an updated panorama of our different transmission studies and discuss the implications of such extended incubation periods on risk assessment of animal PD for human health.

 

===============

 

***thus questioning the origin of human sporadic cases***

 

===============

 


 

***This information will have a scientific impact since it is the first study that demonstrates the transmission of scrapie to a non-human primate with a close genetic relationship to humans. This information is especially useful to regulatory officials and those involved with risk assessment of the potential transmission of animal prion diseases to humans.

 

***This observation strengthens the questioning of the harmlessness of scrapie to humans, at a time when protective measures for human and animal health are being dismantled and reduced as c-BSE is considered controlled and being eradicated. Our results underscore the importance of precautionary and protective measures and the necessity for long-term experimental transmission studies to assess the zoonotic potential of other animal prion strains.

 


 

Monday, November 16, 2015

 

Docket No. APHIS-2007-0127 Scrapie in Sheep and Goats Terry Singeltary Sr. Submission

 


 

Your comment was submitted successfully!

 

Comment Tracking Number: xxxxxxxxxxxxxx

 

Your comment may be viewable on Regulations.gov once the agency has reviewed it. This process is dependent on agency public submission policies/procedures and processing times. Use your tracking number to find out the status of your comment.

 

Agency: Animal and Plant Health Inspection Service (APHIS) Document Type: Rulemaking Title: Scrapie in Sheep and Goats Document ID: APHIS-2007-0127-0001

 

end...tss

 

Terry S. Singeltary Sr.

 

 

Wednesday, November 18, 2015

 

TEXAS Mule Deer Outlook Promising; Hunters Reminded of Mandatory CWD Testing

 


 

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