News Release Media Contact: Steve Lightfoot, 512-389-4701,
steve.lightfoot@tpwd.texas.gov
Nov. 17, 2015
Mule Deer Outlook Promising; Hunters Reminded of Mandatory CWD
Testing
AUSTIN – Prospects are good for the upcoming mule deer hunting season,
which gets under way Saturday, Nov. 21 in the Texas Panhandle and Nov. 27 in the
Trans Pecos. Texas Parks and Wildlife Department biologists say above average
habitat conditions have bolstered body weights and antler growth this year.
Also, the state agency is asking hunters and landowners to submit harvested mule
deer for sampling as part of enhanced, statewide monitoring efforts for Chronic
Wasting Disease.
Although not required in the Panhandle, mule deer harvested in far West
Texas are required to be submitted for testing under TPWD’s Chronic Wasting
Disease Management Plan protocols. The plan includes mandatory check stations
for susceptible species like elk and mule deer taken inside the CWD Containment
Zone, which covers portions of Hudspeth, Culberson, and El Paso counties. See a
Texas CWD zones map on the department’s website.
The Texas Animal Health Commission and TPWD will also use the CWD check
stations in a cooperative effort to monitor for bovine tuberculosis (TB) in
Texas. The tissue samples used for this effort would be the same samples
currently collected as part of the ongoing CWD monitoring effort.
Hunters taking mule deer inside the Containment Zone during the 2015-16
mule deer hunting season are required to submit their harvest (unfrozen head)
for CWD sampling at a check station within 24 hours of take. Over 800 tissue
samples have been collected for CWD testing purposes from hunter-harvested deer
and elk from the Trans Pecos ecoregion the past three hunting seasons, and CWD
has not been detected in mule deer located outside of the Hueco Mountain
area.
“We recommend hunters in the Containment Zone and High Risk Zone quarter
deer in the field and leave all but the quarters, backstraps, and head at the
site of harvest if they are unable to bury the inedible carcass parts as deep as
possible on the ranch or take them to a landfill,” said Shawn Gray, Mule Deer
Program Leader for TPWD.
Mandatory check stations will be open from 9 a.m. to 9 p.m. Nov. 27 – Dec.
13 and 9 a.m. to 7 p.m. on Dec 14. Stations will be located in Cornudas at May’s
Café (on US 62-180) and in Van Horn at the Van Horn Convention Center (1801 West
Broadway).
Hunters who harvest deer in the Containment Zone outside the general season
under the authority of MLDP (Managed Lands Deer Permits) will need to call TPWD
at (512) 221-8491 the day the deer is harvested to make arrangements to have the
deer sampled for CWD.
Deer and elk harvested in other areas of the Trans Pecos and Panhandle
regions may present their deer for CWD testing, to aid in statewide surveillance
effort to contain the disease. A voluntary check station will be established at
the Hip-O Taxidermy in Alpine (east side of town on US 90, across from Dairy
Queen) during the first three weekends of the general season, Saturday through
Monday (Nov. 28–30, Dec. 5–7, and Dec. 12–14), from 9 a.m. – 5 p.m. Saturday and
Sunday and 9 a.m. – 1 p.m. Monday. Other check station locations are illustrated
on a map shown on TPWD’s main CWD web page.
All deer brought to the check stations this season will be aged as part of
disease surveillance. Additional biological information such as antler
measurements and field dressed weights will also be collected as time
allows.
SL 2015-11-17
http://tpwd.texas.gov/newsmedia/releases/?req=20151117b
Wednesday, March 18, 2015
*** Chronic Wasting Disease CWD Confirmed Texas Trans Pecos March 18, 2015
8 CASES DOCUMENTED IN WILD IN THAT AREA TO DATE
http://chronic-wasting-disease.blogspot.com/2015/03/chronic-wasting-disease-cwd-confirmed.html
Saturday, November 14, 2015
TEXAS CAPTIVE BREEDER CHRONIC WASTING DISEASE CWD 2 MORE SUSPECTS DECTECTED
BRINGING NUMBER TO 7 DETECTED IN CAPTIVE BREEDER (if/when the last two are
confirmed).
http://chronic-wasting-disease.blogspot.com/2015/11/texas-captive-breeder-chronic-wasting.html
Monday, November 16, 2015
TEXAS PARKS AND WILDLIFE DEPARTMENT EXECUTIVE DIRECTOR ORDER NO. 015-006
Chronic Wasting Disease (CWD) immediate danger to the white-tailed deer and mule
deer resources of Texas
http://chronic-wasting-disease.blogspot.com/2015/11/texas-parks-and-wildlife-department.html
Thursday, September 24, 2015
TEXAS Hunters Asked to Submit Samples for Chronic Wasting Disease CWD TSE
Prion Testing
*** I cannot stress enough to all of you, for the sake of your family and
mine, before putting anything in the freezer, have those deer tested for CWD.
...terry
http://chronic-wasting-disease.blogspot.com/2015/09/texas-hunters-asked-to-submit-samples.html
Saturday, October 03, 2015
TEXAS CHRONIC WASTING DISEASE CWD TSE PRION GOD MUST NOT BE A TEXAN 2002 TO
2015
http://chronic-wasting-disease.blogspot.com/2015/10/texas-chronic-wasting-disease-cwd-tse.html
Wednesday, March 25, 2015
*** Chronic Wasting Disease CWD Cases Confirmed In New Mexico 2013 and 2014
UPDATE 2015
http://chronic-wasting-disease.blogspot.com/2015/03/chronic-wasting-disease-cwd-cases.html
Wyoming WGF Commission Meeting 11/6/2015 Afternoon Edition Video
CWD starts at minute 58:51 of first hour of meeting discussion of previous
models predicting extinction of deer population and elk population.
please mark hour 1:02 where remarks were made about potential resistant
genes and prolonged survival, however a recent study (I posted directly next
after youtube link) where it states ;
‘’Our study also demonstrates that mice expressing the deer S96-PRNP
allele, previously shown to be resistant to various cervid prions, are
susceptible to H95+ CWD prions. The potential for the generation of novel
strains raises the possibility of an expanded host range for CWD. ‘’
hour minute mark 1:03
captive Elk study
39 femail elk calves captured on National Elk Refuge In Jackson, WY
Transported to WGFD Thorne-Williams Wildlife Research Unit (Sybille,
TWWRU)
Worst-case scenario for prion exposure
Genotypes
-27 M/M132 (69.2%)
-11 M/L132 (28.2%)
-1 L/L132 (2.6%)
38 of 39 elk died over 10-year study
1 remaining elk was L/L132
still alive and remained negative for PrPCWD by rectal biopsy
Appears healthy, weighs 242kg, and bore healthy calf in May, 2012
CWD infection rate in this study ???
https://www.youtube.com/watch?v=bnlk4kW3fFw
> During the analysis, 37 of 39 elk died, all of which were positive for
CWD.
http://www.esajournals.org/doi/pdf/10.1890/ES14-00013.1
*** Our study also demonstrates that mice expressing the deer S96-PRNP
allele, previously shown to be resistant to various cervid prions, are
susceptible to H95+ CWD prions. ***
*** The potential for the generation of novel strains raises the
possibility of an expanded host range for CWD. ***
Deer Prion Proteins Modulate the Emergence and Adaptation of Chronic
Wasting Disease Strains
Camilo Duque Velásqueza,b, Chiye Kima,c, Allen Herbsta,b, Nathalie
Daudea,d, Maria Carmen Garzaa,e, Holger Willea,e, Judd Aikena,b and Debbie
McKenziea,c aCentre for Prions and Protein Folding Diseases, University of
Alberta, Edmonton, Alberta, Canada bDepartment of Agricultural, Food and
Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
cDepartment of Biological Sciences, University of Alberta, Edmonton, Alberta,
Canada dDepartment of Medicine, University of Alberta, Edmonton, Alberta, Canada
eDepartment of Biochemistry, University of Alberta, Edmonton, Alberta, Canada
B. Caughey, Editor
+ Author Affiliations
ABSTRACT
Transmission of chronic wasting disease (CWD) between cervids is influenced
by the primary structure of the host cellular prion protein (PrPC). In
white-tailed deer, PRNP alleles encode the polymorphisms Q95 G96 (wild type
[wt]), Q95 S96 (referred to as the S96 allele), and H95 G96 (referred to as the
H95 allele), which differentially impact CWD progression. We hypothesize that
the transmission of CWD prions between deer expressing different allotypes of
PrPC modifies the contagious agent affecting disease spread. To evaluate the
transmission properties of CWD prions derived experimentally from deer of four
PRNP genotypes (wt/wt, S96/wt, H95/wt, or H95/S96), transgenic (tg) mice
expressing the wt allele (tg33) or S96 allele (tg60) were challenged with these
prion agents. Passage of deer CWD prions into tg33 mice resulted in 100% attack
rates, with the CWD H95/S96 prions having significantly longer incubation
periods. The disease signs and neuropathological and protease-resistant prion
protein (PrP-res) profiles in infected tg33 mice were similar between groups,
indicating that a prion strain (Wisc-1) common to all CWD inocula was amplified.
In contrast, tg60 mice developed prion disease only when inoculated with the
H95/wt and H95/S96 CWD allotypes. Serial passage in tg60 mice resulted in
adaptation of a novel CWD strain (H95+) with distinct biological properties.
Transmission of first-passage tg60CWD-H95+ isolates into tg33 mice, however,
elicited two prion disease presentations consistent with a mixture of strains
associated with different PrP-res glycotypes. Our data indicate that H95-PRNP
heterozygous deer accumulated two CWD strains whose emergence was dictated by
the PrPC primary structure of the recipient host. These findings suggest that
CWD transmission between cervids expressing distinct PrPC molecules results in
the generation of novel CWD strains.
IMPORTANCE CWD prions are contagious among wild and captive cervids in
North America and in South Korea. We present data linking the amino acid variant
Q95H in white-tailed deer cellular prion protein (PrPC) to the emergence of a
novel CWD strain (H95+). We show that, upon infection, deer expressing H95-PrPC
molecules accumulated a mixture of CWD strains that selectively propagated
depending on the PRNP genotype of the host in which they were passaged. Our
study also demonstrates that mice expressing the deer S96-PRNP allele,
previously shown to be resistant to various cervid prions, are susceptible to
H95+ CWD prions. The potential for the generation of novel strains raises the
possibility of an expanded host range for CWD.
*** Our study also demonstrates that mice expressing the deer S96-PRNP
allele, previously shown to be resistant to various cervid prions, are
susceptible to H95+ CWD prions. ***
*** The potential for the generation of novel strains raises the
possibility of an expanded host range for CWD. ***
UPDATE CWD VACCINE ELK minute mark 1:22:00
VACCINE
RECOMBINANT PROTEIN FUSION VACCINE
Hedlin, PD et al ‘’Design and delivery of a cryptic PrP c epitope for
induction of Prp Sc-specific antibody responses.’’ Vaccine 28.4 (2010)
981-988.
PAN-PROVINCIAL VACCINE ENTERPRISES (PREVENT)
Dose: 2ml IM CWD VACCINE UPDATE IS A FAILURE, I REPEAT, A NEGATIVE RESULTS
FOR CWD VACCINE. .tss
https://www.youtube.com/watch?v=bnlk4kW3fFw
Monday, November 16, 2015
*** Wyoming Latest round of testing CWD surveillance program has found the
disease in three new hunt areas
http://chronic-wasting-disease.blogspot.com/2015/11/wyoming-latest-round-of-testing-cwd.html
P.97: Scrapie transmits to white-tailed deer by the oral route and has a
molecular profile similar to chronic wasting disease and distinct from the
scrapie inoculum
Justin Greenlee1, S Jo Moore1, Jodi Smith1, M Heather West Greenlee2, and
Robert Kunkle1 1National Animal Disease Center; Ames, IA USA; 2Iowa State
University; Ames, IA USA
The purpose of this work was to determine susceptibility of white-tailed
deer (WTD) to the agent of sheep scrapie and to compare the resultant PrPSc to
that of the original inoculum and chronic wasting disease (CWD). We inoculated
WTD by a natural route of exposure (concurrent oral and intranasal (IN); n D 5)
with a US scrapie isolate. All scrapie-inoculated deer had evidence of PrPSc
accumulation. PrPSc was detected in lymphoid tissues at preclinical time points,
and deer necropsied after 28 months post-inoculation had clinical signs,
spongiform encephalopathy, and widespread distribution of PrPSc in neural and
lymphoid tissues. Western blotting (WB) revealed PrPSc with 2 distinct molecular
profiles. WB on cerebral cortex had a profile similar to the original scrapie
inoculum, whereas WB of brainstem, cerebellum, or lymph nodes revealed PrPSc
with a higher profile resembling CWD. Homogenates with the 2 distinct profiles
from WTD with clinical scrapie were further passaged to mice expressing cervid
prion protein and intranasally to sheep and WTD. In cervidized mice, the 2
inocula have distinct incubation times. Sheep inoculated intranasally with WTD
derived scrapie developed disease, but only after inoculation with the inoculum
that had a scrapie-like profile. The WTD study is ongoing, but deer in both
inoculation groups are positive for PrPSc by rectal mucosal biopsy. In summary,
this work demonstrates that WTD are susceptible to the agent of scrapie, 2
distinct molecular profiles of PrPSc are present in the tissues of affected
deer, and inoculum of either profile readily passes to deer.
https://prion2015.files.wordpress.com/2015/05/prion2015abstracts.pdf
Saturday, January 31, 2015
European red deer (Cervus elaphus elaphus) are susceptible to Bovine
Spongiform Encephalopathy BSE by Oral Alimentary route
http://transmissiblespongiformencephalopathy.blogspot.com/2015/01/european-red-deer-cervus-elaphus.html
I strenuously once again urge the FDA and its industry constituents, to
make it MANDATORY that all ruminant feed be banned to all ruminants, and this
should include all cervids as soon as possible for the following
reasons...
======
In the USA, under the Food and Drug Administrations BSE Feed Regulation (21
CFR 589.2000) most material (exceptions include milk, tallow, and gelatin) from
deer and elk is prohibited for use in feed for ruminant animals. With regards to
feed for non-ruminant animals, under FDA law, CWD positive deer may not be used
for any animal feed or feed ingredients. For elk and deer considered at high
risk for CWD, the FDA recommends that these animals do not enter the animal feed
system.
***However, this recommendation is guidance and not a requirement by law.
======
31 Jan 2015 at 20:14 GMT
*** Ruminant feed ban for cervids in the United States? ***
31 Jan 2015 at 20:14 GMT
http://www.plosone.org/annotation/listThread.action?root=85351
Monday, October 26, 2015
*** FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED
VIOLATIONS OFFICIAL ACTION INDICATED OIA UPDATE October 2015 ***
http://madcowusda.blogspot.com/2015/10/fda-part-589-substances-prohibited-from.html
Sunday, October 25, 2015
*** USAHA Detailed Events Schedule – 119th USAHA Annual Meeting CAPTIVE
LIVESTOCK CWD SCRAPIE TSE PRION ***
http://chronic-wasting-disease.blogspot.com/2015/10/usaha-detailed-events-schedule-119th.html
Docket No. APHIS-2007-0127 Scrapie in Sheep and Goats Terry Singeltary Sr.
Submission
Docket No. APHIS-2007-0127 Scrapie in Sheep and Goats
SUMMARY: We are reopening the comment period for our proposed rule that
would revise completely the scrapie regulations, which concern the risk groups
and categories established for individual animals and for flocks, the use of
genetic testing as a means of assigning risk levels to animals, movement
restrictions for animals found to be genetically less susceptible or resistant
to scrapie, and recordkeeping requirements. This action will allow interested
persons additional time to prepare and submit comments.DATES: The comment period
for the proposed rule published on September 10, 2015 (80 FR 54660-54692) is
reopened. We will consider all comments that we receive on or before December 9,
2015. ...
http://www.regulations.gov/#!documentDetail;D=APHIS-2007-0127-0001
http://www.gpo.gov/fdsys/pkg/FR-2015-11-16/html/2015-29179.htm
http://www.regulations.gov/#!docketDetail;D=APHIS-2007-0127
COMMENT SUBMISSION TERRY S. SINGELTARY SR.
WITH regards to Docket No. APHIS-2007-0127 Scrapie in Sheep and Goats, I
kindly submit the following ;
>>>The last major revision of the scrapie regulations occurred on
August 21, 2001, when we published in theFederal Register(66 FR 43964, Docket
No. 97-093-5) a final rule amending part 79 by imposing additional restrictions
on the interstate movement of sheep and goats.<<<
Indeed, much science has changed about the Scrapie TSE prion, including
more science linking Scrapie to humans. sadly, politics, industry, and trade,
have not changed, and those usually trump sound science, as is the case with all
Transmissible Spongiform Encephalopathy TSE Prion disease in livestock producing
animals and the OIE. we can look no further at the legal trading of the Scrapie
TSE prion both typical and atypical of all strains, and CWD all stains. With as
much science of old, and now more new science to back this up, Scrapie of all
types i.e. atypical and typical, BSE all strains, and CWD all strains, should be
regulated in trade as BSE TSE PRION. In fact, I urge APHIS et al and the OIE,
and all trading partners to take heed to the latest science on the TSE prion
disease, all of them, and seriously reconsider the blatant disregards for human
and animal health, all in the name of trade, with the continued relaxing of TSE
Prion trade regulations through the ‘NEGLIGIBLE BSE RISK’ PROGRAM, which was set
up to fail in the first place. If the world does not go back to the ‘BSE RISK
ASSESSMENTS’, enhance, and or change that assessment process to include all TSE
prion disease, i.e. ‘TSE RISK ASSESSMENT’, if we do not do this and if we
continue this farce with OIE and the USDA et al, and the ‘NEGLIGIBLE BSE RISK’
PROGRAM, we will never eradicate the TSE prion aka mad cow type disease, they
will continue to mutate and spread among species of human and animal origin, and
they will continue to kill. ...
please see ;
O.05: Transmission of prions to primates after extended silent incubation
periods: Implications for BSE and scrapie risk assessment in human populations
Emmanuel Comoy, Jacqueline Mikol, Val erie Durand, Sophie Luccantoni,
Evelyne Correia, Nathalie Lescoutra, Capucine Dehen, and Jean-Philippe Deslys
Atomic Energy Commission; Fontenay-aux-Roses, France
Prion diseases (PD) are the unique neurodegenerative proteinopathies
reputed to be transmissible under field conditions since decades. The
transmission of Bovine Spongiform Encephalopathy (BSE) to humans evidenced that
an animal PD might be zoonotic under appropriate conditions. Contrarily, in the
absence of obvious (epidemiological or experimental) elements supporting a
transmission or genetic predispositions, PD, like the other proteinopathies, are
reputed to occur spontaneously (atpical animal prion strains, sporadic CJD
summing 80% of human prion cases). Non-human primate models provided the first
evidences supporting the transmissibiity of human prion strains and the zoonotic
potential of BSE. Among them, cynomolgus macaques brought major information for
BSE risk assessment for human health (Chen, 2014), according to their
phylogenetic proximity to humans and extended lifetime. We used this model to
assess the zoonotic potential of other animal PD from bovine, ovine and cervid
origins even after very long silent incubation periods.
*** We recently observed the direct transmission of a natural classical
scrapie isolate to macaque after a 10-year silent incubation period,
***with features similar to some reported for human cases of sporadic CJD,
albeit requiring fourfold longe incubation than BSE. Scrapie, as recently evoked
in humanized mice (Cassard, 2014),
***is the third potentially zoonotic PD (with BSE and L-type BSE),
***thus questioning the origin of human sporadic cases. We will present an
updated panorama of our different transmission studies and discuss the
implications of such extended incubation periods on risk assessment of animal PD
for human health.
===============
***thus questioning the origin of human sporadic cases***
===============
***This information will have a scientific impact since it is the first
study that demonstrates the transmission of scrapie to a non-human primate with
a close genetic relationship to humans. This information is especially useful to
regulatory officials and those involved with risk assessment of the potential
transmission of animal prion diseases to humans.
***This observation strengthens the questioning of the harmlessness of
scrapie to humans, at a time when protective measures for human and animal
health are being dismantled and reduced as c-BSE is considered controlled and
being eradicated. Our results underscore the importance of precautionary and
protective measures and the necessity for long-term experimental transmission
studies to assess the zoonotic potential of other animal prion strains.
Monday, November 16, 2015
Docket No. APHIS-2007-0127 Scrapie in Sheep and Goats Terry Singeltary Sr.
Submission
Your comment was submitted successfully!
Comment Tracking Number: xxxxxxxxxxxxxx
Your comment may be viewable on Regulations.gov once the agency has
reviewed it. This process is dependent on agency public submission
policies/procedures and processing times. Use your tracking number to find out
the status of your comment.
Agency: Animal and Plant Health Inspection Service (APHIS) Document Type:
Rulemaking Title: Scrapie in Sheep and Goats Document ID:
APHIS-2007-0127-0001
end...tss
Terry S. Singeltary Sr.
Wednesday, November 18, 2015
TEXAS Mule Deer Outlook Promising; Hunters Reminded of Mandatory CWD
Testing
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