Chronic Wasting Disease: Norway Chronic Wasting Disease CWD TSE Prion disease Skrantesjuke December 2016 Update

Norway Chronic Wasting Disease CWD TSE Prion disease Skrantesjuke December 2016 Update

CWD update from Norway December 2016 Screening work for CWD in wild deer in Norway from this year’s hunting season is now completed, with 6000 animals tested from all over the country, including 2000 red deer. We have two more cases, a 7 year old male and 4 year old female reindeer, both from the Nordfjella herd. That’s the same herd as the other ‘positive’ reindeer. Both were in apparently good health; the male was a fine specimen (see photo in link).

824 additional animals which died in accidents or were found dead in 2016 were screened as well (routine practice, and how the 3 previous positives were discovered) , 0 positives there.

So in all we have had 5 positive tests, 2 in female moose in Selbu SE of Trondheim, which showed symptoms but were both very old (13 and 14 years old); and 2 females and a male in reindeer in the same isolated group in southern Norway, none of them old - the original female was 3 to 4 years old - and none of which showed symptoms.

We’re still checking semi-domestic reindeer as the main slaughter is still underway. 0 positive from 824 tested individuals there so far.

So, we can be sure prevalence is low (0.0003% of wild deer tested in 2016), appears restricted to very small geographical areas, and so far none in red deer despite the very large sample.

http://www.miljodirektoratet.no/no/Nyheter/Nyheter/2016/November-2016/To-av-6-000-haddeskrantesjuke/

So far as it goes indicates low prevalence, and apparently not affecting carriers, except for old animals. Remains early days, but data is consistent with the theory that it’s epidemic and fatal in N. American deer because it is new to them.

We’re now working out what to do in the future. Continued screening and more focused research will be first. The Nordfjella reindeer management area, which has 2500 animals in total, divides into two geographical subareas north and south separated by a road. This is a strong barrier to reindeer movement. All the positives are from the north.

http://www.bds.org.uk/index.php/documents/125-cwd-update-from-norway-dec-16/file

Proposed Amendment of CWD Regulations - measures to prevent the spread of skrantesjuke

Publisert 06.12.2016 | Published 06/12/2016 | Sist endret 06.12.2016 Last modified 06/12/2016 Skriv ut Print

Chronic Wasting Disease (CWD), også kjent som skrantesjuke, er en dødelig hjortesykdom som ble oppdaget i Norge for første gang i april 2016. En midlertidig forskrift med tiltak for å hindre spredning av sykdommen ble fastsatt i juli i år. Chronic Wasting Disease (CWD), also known as skrantesjuke, is a deadly deer disease was detected in Norway for the first time in April 2016. A temporary regulation on measures to prevent the spread of the disease was established in July this year. Den midlertidige CWD-forskrift gjelder bare frem til 1. januar 2017. I løpet av høsten er det tatt mange tusen prøver av hjortedyr for å kartlegge forekomsten av sykdommen og det er per november 2016 funnet fem CWD-positive dyr. The temporary CWD regulations apply only until 1 January 2017. In the autumn it is taken thousands of samples of deer to investigate the prevalence of the disease and it is per November 2016 found five CWD-positive animals. Mattilsynet mener at det er nødvendig å fortsette med tiltak som kan hindre spredning av skrantesjuke. FSA believes that it is necessary to continue with measures to prevent the spread of skrantesjuke.

I høringen desember 2016 er det foreslått at CWD-forskriften videreføres inntil en mer permanent forskrift sendes på høring. In the hearing in December 2016, it is proposed that CWD Regulations continued until a more permanent regulations are circulated. Det foreslås samtidig noen mindre endringer av gjeldende forskrift slik at fôr til tamrein og ville hjortedyr kan legges ut i enkelte tilfeller. It is proposed that some minor changes to existing regulations so that fodder for reindeer and wild deer can be laid out in some cases.

Se også høringsbrevet fra juni 2016 . See also the consultative document from June 2016 .

Gangen i arbeidet er beskrevet i tidslinjen under, og den svarte boksen viser hvor vi er i prosessen.

The decline in the work described in the timeline below, and the black box shows where we are in the process.

http://www.mattilsynet.no/dyr_og_dyrehold/dyrehelse/dyresykdommer/skrantesjuke__cwd_/forslag_til_endring_av_cwdforskriften__tiltak_for_aa_hindre_spredning_av_skrantesjuke.24836

https://translate.google.com/translate?sl=auto&tl=en&js=y&prev=_t&hl=en&ie=UTF-8&u=http%3A%2F%2Fwww.mattilsynet.no%2Fdyr_og_dyrehold%2Fdyrehelse%2Fdyresykdommer%2Fskrantesjuke__cwd_%2Fforslag_til_endring_av_cwdforskriften__tiltak_for_aa_hindre_spredning_av_skrantesjuke.24836&edit-text=

STATUS ON CWD IN NORWAY TO DATE

http://www.mattilsynet.no/dyr_og_dyrehold/dyrehelse/dyresykdommer/skrantesjuke__cwd_/status_paa_kartleggingen_av_skrantesjuke.23546

MAJOR FINDINGS FOR NORWAY !

Title: Pathological features of chronic wasting disease in reindeer and demonstration of horizontal transmission

Author item Moore, Sarah item Kunkle, Robert item West greenlee, Mary item Nicholson, Eric item Richt, Juergen item Hamir, Amirali item Waters, Wade item Greenlee, Justin Submitted to: Emerging Infectious Diseases Publication Type: Peer reviewed journal Publication Acceptance Date: 8/29/2016 Publication Date: N/A Citation: Interpretive

Summary: Chronic wasting disease (CWD) is a fatal neurodegenerative disease that occurs in farmed and wild cervids (deer and elk) of North America and was recently diagnosed in a single free-ranging reindeer (Rangifer tarandus tarandus) in Norway. CWD is a transmissible spongiform encephalopathy (TSE) that is caused by infectious proteins called prions that are resistant to various methods of decontamination and environmental degradation. Little is known about the susceptibility of or potential for transmission amongst reindeer. In this experiment, we tested the susceptibility of reindeer to CWD from various sources (elk, mule deer, or white-tailed deer) after intracranial inoculation and tested the potential for infected reindeer to transmit to non-inoculated animals by co-housing or housing in adjacent pens. Reindeer were susceptible to CWD from elk, mule deer, or white-tailed deer sources after experimental inoculation. Most importantly, non-inoculated reindeer that were co-housed with infected reindeer or housed in pens adjacent to infected reindeer but without the potential for nose-to-nose contact also developed evidence of CWD infection.

This is a major new finding that may have a great impact on the recently diagnosed case of CWD in the only remaining free-ranging reindeer population in Europe as our findings imply that horizontal transmission to other reindeer within that herd has already occurred.

Further, this information will help regulatory and wildlife officials developing plans to reduce or eliminate CWD and cervid farmers that want to ensure that their herd remains CWD-free, but were previously unsure of the potential for reindeer to transmit CWD. Technical Abstract: Chronic wasting disease (CWD) is a naturally-occurring, fatal prion disease of cervids. Reindeer (Rangifer tarandus tarandus) are susceptible to CWD following oral challenge, and CWD was recently reported in a free-ranging reindeer of Norway. Potential contact between CWD-affected cervids and Rangifer species that are free-ranging or co-housed on farms presents a potential risk of CWD transmission.

The aims of this study were to

investigate the transmission of CWD from white-tailed deer (Odocoileus virginianus; CWDwtd), mule deer (Odocoileus hemionus; CWDmd), or elk (Cervus elaphus nelsoni; CWDelk) to reindeer via the intracranial route, and 2) to assess for direct and indirect horizontal transmission to non-inoculated sentinels. Three groups of 5 reindeer fawns were challenged intracranially with CWDwtd, CWDmd, or CWDelk. Two years after challenge of inoculated reindeer, non-inoculated negative control reindeer were introduced into the same pen as the CWDwtd inoculated reindeer (direct contact; n=4) or into a pen adjacent to the CWDmd inoculated reindeer (indirect contact; n=2). Experimentally inoculated reindeer were allowed to develop clinical disease. At death/euthanasia a complete necropsy examination was performed, including immunohistochemical testing of tissues for disease-associated CWD prion protein (PrPcwd). Intracranially challenged reindeer developed clinical disease from 21 months post-inoculation (months PI). PrPcwd was detected in 5 out of 6 sentinel reindeer although only 2 out of 6 developed clinical disease during the study period (< 57 months PI). We have shown that reindeer are susceptible to CWD from various cervid sources and can transmit CWD to naïve reindeer both directly and indirectly.

Monday, September 05, 2016

*** Pathological features of chronic wasting disease in reindeer and demonstration of horizontal transmission Major Findings for Norway ***

https://www.ars.usda.gov/research/publications/publication/?seqNo115=328261

Sunday, November 13, 2016

Horizontal Transmission of Chronic Wasting Disease in Reindeer CDC Volume 22, Number 12—December 2016

http://chronic-wasting-disease.blogspot.com/2016/11/horizontal-transmission-of-chronic.html

SUNDAY, OCTOBER 02, 2016

What is the risk of a cervid TSE being introduced from Norway into Great Britain? Qualitative Risk Assessment September 2016

http://chronic-wasting-disease.blogspot.com/2016/10/what-is-risk-of-cervid-tse-being.html

Thursday, September 22, 2016

NORWAY DETECTS 5TH CASE OF CHRONIC WASTING DISEASE CWD TSE PRION Skrantesjuke

http://chronic-wasting-disease.blogspot.com/2016/09/norway-detects-5th-case-of-chronic.html

Saturday, September 03, 2016

NORWAY Regulation concerning temporary measures to reduce the spread of Chronic Wasting Disease (CWD) as 4th case of skrantesjuke confirmed in Sogn og Fjordane

http://chronic-wasting-disease.blogspot.com/2016/09/norway-regulation-concerning-temporary.html

Wednesday, August 31, 2016

*** NORWAY CONFIRMS 4TH CASE OF CHRONIC WASTING DISEASE CWD TSE PRION IN SECOND CARIBOU

http://chronic-wasting-disease.blogspot.com/2016/08/norway-confirms-4th-case-of-chronic.html

Wednesday, August 31, 2016

NORWAY CONFIRMS 4TH CASE OF CHRONIC WASTING DISEASE CWD TSE PRION IN SECOND CARIBOU

http://chronic-wasting-disease.blogspot.com/2016/08/norway-confirms-4th-case-of-chronic.html

Tuesday, August 02, 2016

Chronic wasting disease of deer – is the battle to keep Europe free already lost?

http://chronic-wasting-disease.blogspot.com/2016/08/chronic-wasting-disease-of-deer-is.html

Tuesday, June 14, 2016

*** Chronic Wasting Disease (CWD) in a moose from Selbu in Sør-Trøndelag Norway ***

http://chronic-wasting-disease.blogspot.com/2016/06/chronic-wasting-disease-cwd-in-moose.html

Thursday, July 07, 2016

Norway reports a third case Chronic Wasting Disease CWD TSE Prion in 2nd Norwegian moose

14/06/2016 - Norway reports a third case

http://chronic-wasting-disease.blogspot.com/2016/07/norway-reports-third-case-chronic.html

Saturday, July 16, 2016

Chronic wasting Disease in Deer (CWD or Spongiform Encephalopathy) The British Deer Society 07/04/2016

Red Deer Ataxia or Chronic Wasting Disease CWD TSE PRION?

could this have been cwd in the UK back in 1970’S ???

http://collections.europarchive.org/tna/20090505194948/http://bseinquiry.gov.uk/files/yb/1982/07/05001001.pdf

http://collections.europarchive.org/tna/20090505194948/http://bseinquiry.gov.uk/files/yb/1982/07/28001001.pdf

http://collections.europarchive.org/tna/20090505194948/http://bseinquiry.gov.uk/files/yb/1983/03/01001001.pdf

http://www.tandfonline.com/doi/pdf/10.1080/00480169.1979.34665

SEE FULL TEXT ;

http://chronic-wasting-disease.blogspot.com/2016/07/chronic-wasting-disease-in-deer-cwd-or.html

Tuesday, April 12, 2016

The first detection of Chronic Wasting Disease (CWD) in Europe free-ranging reindeer from the Nordfjella population in South-Norway.

http://chronic-wasting-disease.blogspot.com/2016/04/the-first-detection-of-chronic-wasting.html

Saturday, April 9, 2016

The Norwegian Veterinary Institute (NVI, 2016) has reported a case of prion disease Cervid Spongiform Encephalopathy detected in free ranging wild reindeer (Rangifer tarandus tarandus)

Department for Environment, Food and Rural Affairs

http://transmissiblespongiformencephalopathy.blogspot.com/2016/04/the-norwegian-veterinary-institute-nvi.html

Wednesday, September 28, 2016

Norway sides with OIE, decides to expose millions of consumers to the ATYPICAL BSE SRM TSE Prion aka mad cow type disease

http://bse-atypical.blogspot.com/2016/09/norway-sides-with-oie-decides-to-expose.html

Thursday, January 29, 2015

Atypical H-TYPE BSE Case Confirmed in Norway

http://bse-atypical.blogspot.com/2015/01/atypical-h-type-bse-case-confirmed-in.html

CDC EMERGING INFECTIOUS DISEASE JOURNAL DECEMBER 2016 CWD HORIZONTAL TRANSMISSION

http://wwwnc.cdc.gov/eid/article/22/12/16-0635_article

Thursday, December 08, 2016

TEXAS TAHC confirmed Chronic Wasting Disease (CWD) in a free-ranging elk Dallam County