Wyoming CWD found in new elk hunt area in Southeast Washakie County
CWD found in new elk hunt area in Southeast Washakie County
The Wyoming Game and Fish Department has diagnosed chronic wasting disease (CWD) in a cow elk that was found dead in southeast Washakie County.
7/26/2017 11:10:05 AM
CHEYENNE -
The Wyoming Game and Fish Department has diagnosed chronic wasting disease (CWD) in a cow elk that was found dead in southeast Washakie County. The elk was found about 30 miles southwest of Kaycee. The dead elk was part of the Bighorns elk movement study. This study is evaluating the migrations and behaviors of elk in the Bighorn Mountains. CWD is less common in elk than it is in deer, and CWD has been documented in this part of the state in deer, for elk it has previously been detected to the northeast of Elk Hunt Area 48, where this recent cow elk was found, in Elk Hunt Area 34. “We have many means of monitoring for CWD and following its movement across the state. The disease moves very slowly, especially in elk, but this research and data is necessary as it will guide our future management decisions,” said Scott Edberg, deputy division chief of the Wildlife Division. “We will continue our increased level of monitoring and ask for those who hunt to help by submitting harvested animals for testing. We also ask that those who see a sick animal to report it to Game and Fish.” Last year, Game and Fish personnel collected and analyzed more than 3,350 CWD samples throughout the state, a significant increase from past years. This year Game and Fish will sample a similar number.
Please visit the Game and Fish website for more information on chronic wasting disease transmission and regulations on transportation and disposal of carcasses. (renny.mackay1@wyo.gov)
- WGFD -
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Stefanie Czub1, Walter Schulz-Schaeffer2, Christiane Stahl-Hennig3, Michael Beekes4, Hermann Schaetzl5 and Dirk Motzkus6 1
University of Calgary Faculty of Veterinary Medicine/Canadian Food Inspection Agency; 2Universitatsklinikum des Saarlandes und Medizinische Fakultat der Universitat des Saarlandes; 3 Deutsches Primaten Zentrum/Goettingen; 4 Robert-Koch-Institut Berlin; 5 University of Calgary Faculty of Veterinary Medicine; 6 presently: Boehringer Ingelheim Veterinary Research Center; previously: Deutsches Primaten Zentrum/Goettingen
This is a progress report of a project which started in 2009. 21 cynomolgus macaques were challenged with characterized CWD material from white-tailed deer (WTD) or elk by intracerebral (ic), oral, and skin exposure routes. Additional blood transfusion experiments are supposed to assess the CWD contamination risk of human blood product. Challenge materials originated from symptomatic cervids for ic, skin scarification and partially per oral routes (WTD brain). Challenge material for feeding of muscle derived from preclinical WTD and from preclinical macaques for blood transfusion experiments. We have confirmed that the CWD challenge material contained at least two different CWD agents (brain material) as well as CWD prions in muscle-associated nerves.
Here we present first data on a group of animals either challenged ic with steel wires or per orally and sacrificed with incubation times ranging from 4.5 to 6.9 years at postmortem. Three animals displayed signs of mild clinical disease, including anxiety, apathy, ataxia and/or tremor. In four animals wasting was observed, two of those had confirmed diabetes. All animals have variable signs of prion neuropathology in spinal cords and brains and by supersensitive IHC, reaction was detected in spinal cord segments of all animals. Protein misfolding cyclic amplification (PMCA), real-time quaking-induced conversion (RT-QuiC) and PET-blot assays to further substantiate these findings are on the way, as well as bioassays in bank voles and transgenic mice.
At present, a total of 10 animals are sacrificed and read-outs are ongoing. Preclinical incubation of the remaining macaques covers a range from 6.4 to 7.10 years. Based on the species barrier and an incubation time of > 5 years for BSE in macaques and about 10 years for scrapie in macaques, we expected an onset of clinical disease beyond 6 years post inoculation.
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Subject: PRION 2017 CONFERENCE DECIPHERING NEURODEGENERATIVE DISORDERS VIDEO
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PRION 2017 CONFERENCE VIDEO
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***Moreover, sporadic disease has never been observed in breeding colonies or primate research laboratories, most notably among hundreds of animals over several decades of study at the National Institutes of Health25, and in nearly twenty older animals continuously housed in our own facility.***
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Terry S. Singeltary Sr.
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