Accurate Genomic Predictions for Chronic Wasting Disease in U.S. White-tailed Deer
Christopher M Seabury*1, David L Oldeschulte1, Eric K Bhattarai1, Dhruti Legare2, Pamela J
Ferro2, Richard P Metz3, Charles D Johnson3, Mitchell A. Lockwood4, Tracy A. Nichols5
Conclusions
Herein, we demonstrate that differential susceptibility to CWD and variation in natural disease progression are both heritable, polygenic traits in farmed U.S. WTD, and that genome-
wide SNP data can be used to produce accurate genomic predictions for risk (≥ 0.8167); thereby
providing the first novel strategy for reducing the prevalence of CWD.
***>Moreover, given the genomic architecture of these traits, we also demonstrate that PRNP genotyping alone cannot be expected to facilitate an eradication program, or to rapidly reduce the overall prevalence of CWD in farmed U.S. WTD.
CWD WEBINAR CWD YESTERDAY! December 11, 2019
Dr. Mckenzie and CIDRAP on CWD TSE Prion
122: Prions and Chronic Wasting Disease with Jason Bartz
Texas CWD Symposium: Transmission by Saliva, Feces, Urine & Blood
the other part, these tissues and things in the body then shed or secrete prions which then are the route to other animals into the environment, so in particular, the things, the secretions that are infectious are salvia, feces, blood and urine. so pretty much anything that comes out of a deer is going to be infectious and potential for transmitting disease.
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