Thursday, February 07, 2019

CWD TSE Prion, and Processing your own meat

i urge anyone that can, to process your own meat, and be very careful of the tools you use, how to clean them, and don't use those tools for any other purpose, and NO wood handles. this old study always amazes me, never gets old reading it as a reminder. the late Joe Gibbs, a pioneer in the world of tse prion research RIP... 

1: J Neurol Neurosurg Psychiatry 1994 Jun;57(6):757-8 

***> Transmission of Creutzfeldt-Jakob disease to a chimpanzee by electrodes contaminated during neurosurgery.

Gibbs CJ Jr, Asher DM, Kobrine A, Amyx HL, Sulima MP, Gajdusek DC. Laboratory of Central Nervous System Studies, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892. 

Stereotactic multicontact electrodes used to probe the cerebral cortex of a middle aged woman with progressive dementia were previously implicated in the accidental transmission of Creutzfeldt-Jakob disease (CJD) to two younger patients. The diagnoses of CJD have been confirmed for all three cases. More than two years after their last use in humans, after three cleanings and repeated sterilisation in ethanol and formaldehyde vapour, the electrodes were implanted in the cortex of a chimpanzee. Eighteen months later the animal became ill with CJD. This finding serves to re-emphasise the potential danger posed by reuse of instruments contaminated with the agents of spongiform encephalopathies, even after scrupulous attempts to clean them. 

PMID: 8006664 [PubMed - indexed for MEDLINE] 


Philos Trans R Soc Lond B Biol Sci. 2008 Nov 27; 363(1510): 3618–3625. doi: 10.1098/rstb.2008.4002 PMCID: PMC2735519 PMID: 18849246 

Kuru: memories of the NIH years 

David M. Asher*



BSE-The Untold Story - joe gibbs and singeltary 1999 - 2009


KURU


***> This is very likely to have parallels with control efforts for CWD in cervids.

Rapid recontamination of a farm building occurs after attempted prion removal


Kevin Christopher Gough, BSc (Hons), PhD1, Claire Alison Baker, BSc (Hons)2, Steve Hawkins, MIBiol3, Hugh Simmons, BVSc, MRCVS, MBA, MA3, Timm Konold, DrMedVet, PhD, MRCVS3 and Ben Charles Maddison, BSc (Hons), PhD2

Abstract

The transmissible spongiform encephalopathy scrapie of sheep/goats and chronic wasting disease of cervids are associated with environmental reservoirs of infectivity. 

Preventing environmental prions acting as a source of infectivity to healthy animals is of major concern to farms that have had outbreaks of scrapie and also to the health management of wild and farmed cervids. 

Here, an efficient scrapie decontamination protocol was applied to a farm with high levels of environmental contamination with the scrapie agent. 

Post-decontamination, no prion material was detected within samples taken from the farm buildings as determined using a sensitive in vitro replication assay (sPMCA). 

A bioassay consisting of 25 newborn lambs of highly susceptible prion protein genotype VRQ/VRQ introduced into this decontaminated barn was carried out in addition to sampling and analysis of dust samples that were collected during the bioassay. 

Twenty-four of the animals examined by immunohistochemical analysis of lymphatic tissues were scrapie-positive during the bioassay, samples of dust collected within the barn were positive by month 3. 

The data illustrates the difficulty in decontaminating farm buildings from scrapie, and demonstrates the likely contribution of farm dust to the recontamination of these environments to levels that are capable of causing disease.

snip...

As in the authors' previous study,12 the decontamination of this sheep barn was not effective at removing scrapie infectivity, and despite the extra measures brought into this study (more effective chemical treatment and removal of sources of dust) the overall rates of disease transmission mirror previous results on this farm. With such apparently effective decontamination (assuming that at least some sPMCA seeding ability is coincident with infectivity), how was infectivity able to persist within the environment and where does infectivity reside? Dust samples were collected in both the bioassay barn and also a barn subject to the same decontamination regime within the same farm (but remaining unoccupied). Within both of these barns dust had accumulated for three months that was able to seed sPMCA, indicating the accumulation of scrapie-containing material that was independent of the presence of sheep that may have been incubating and possibly shedding low amounts of infectivity.

This study clearly demonstrates the difficulty in removing scrapie infectivity from the farm environment. Practical and effective prion decontamination methods are still urgently required for decontamination of scrapie infectivity from farms that have had cases of scrapie and this is particularly relevant for scrapiepositive goatherds, which currently have limited genetic resistance to scrapie within commercial breeds.24 This is very likely to have parallels with control efforts for CWD in cervids.

Acknowledgements The authors thank the APHA farm staff, Tony Duarte, Olly Roberts and Margaret Newlands for preparation of the sheep pens and animal husbandry during the study. The authors also thank the APHA pathology team for RAMALT and postmortem examination.

Funding This study was funded by DEFRA within project SE1865. 

Competing interests None declared. 


Saturday, January 5, 2019 

Rapid recontamination of a farm building occurs after attempted prion removal 


***> NORWAY CWD UPDATE December 2018

Report from the Norwegian Scientific Committee for Food and Environment (VKM) 2018: 16

Factors that can contribute to spread of CWD – an update on the situation in Nordfjella, Norway

Opinion of Panel on biological hazards of the Norwegian Scientific Committee for Food and Environment

13.12.2018

ISBN: 978-82-8259-316-8

ISSN: 2535-4019

Norwegian Scientific Committee for Food and Environment (VKM)

Po 222 Skøyen

0213 Oslo

Norway

FRIDAY, DECEMBER 14, 2018 

Norway, Nordfjella VKM 2018 16 Factors that can contribute to spread of CWD TSE Prion UPDATE December 14, 2018



THURSDAY, OCTOBER 25, 2018 

***> Norway New additional requirements for imports of hay and straw for animal feed from countries outside the EEA due to CWD TSE Prion


new link;

https://chronic-wasting-disease.blogspot.com/2018/10/norway-new-additional-requirements-for.html

folks, i have followed this circus since 1997, and researched it to the early days of the BSE Inquiry, even made a statement about these snake oil supplements that contained SRMs here in the USA and abroad, i.e. like deer antler velvet in supplements, along with brains, eyes, pituitary and such. even had one company reprocess their manufacturing of some of their products due to the risk factors the tse prion and their products used, much too late though. 

BUT REMEMBER, BSE IS NOT CWD, CWD IS MUCH WORSE, IN MANY WAYS, to date.

also, this was 25 years ago.this is old science. some of this science, transmission, strains, and such, have changed, for the worse.

but this might give you an idea of the concerns of processing meat with BSE TSE Prion aka mad cow disease. these files are archived in my BSE Inquiry files, some of the BSEInquiry Links may be old and not work. if you see one that you might like to have source link that works, let me know, and i will see if i can update...

kind regards, terry

Subject: BSE INQUIRY EARLY DAYS DFA 15 Monitoring and Enforcement of the SBO Specified Bovine Offal Regulations

(xi.) There was concern about contamination during carcase splitting and, in particular, concern that splitting often caused the spinal cord to be severed which could result in small pieces of cord becoming lodged between vertebrae;[14]

(xii.) There was concern about mechanically recovered meat, particularly that recovered from the spinal column;[15]

(xiii.) There was concern that removal of the specified offals did not fully remove the nervous and lymphatic tissue from the animal leaving some of those tissues in food for human consumption;[16]

BSE Inquiry 

DFA 15 Monitoring and Enforcement of the SBO Specified Bovine Offal Regulations


SATURDAY, AUGUST 26, 2017

DFA 14 Consideration of the Risk from Mechanically Recovered Meat (MRM) in 1989-1990



BSE INQUIRY DFA 16 MID 1995 TO THE FINAL DAYS


Wednesday, January 23, 2019 

CFIA SFCR Guidance on Specified risk material (SRM) came into force on January 15, 2019



this is all in the world those 300k+ bovine that died with BSE were consuming, a nutritional supplement with srms...

Sender: "Patricia Cantos"  
To: "Terry S Singeltary Sr. (E-mail)"  
Subject: Your submission to the Inquiry 
Date: Fri, 3 Jul 1998 10:10:05 +0100

3 July 1998 Mr Terry S Singeltary Sr. E-Mail: Flounder at wt.net Ref: E2979

Dear Mr Singeltary,

Thank you for your E-mail message of the 30th of June 1998 providing the Inquiry with your further comments. Thank you for offering to provide the Inquiry with any test results on the nutritional supplements your mother was taking before she died.

As requested I am sending you our general Information Pack and a copy of the Chairman's letter. Please contact me if your system cannot read the attachments.

Regarding your question, the Inquiry is looking into many aspects of the scientific evidence on BSE and nvCJD. I would refer you to the transcripts of evidence we have already heard which are found on our internet site at http://www.bse.org.uk. Could you please provide the Inquiry with a copy of the press article you refer to in your e-mail? If not an approximate date for the article so that we can locate it? In the meantime, thank you for you comments. Please do not hesitate to contact me on 0171 261 8332 should you have any queries.

Yours sincerely Patricia Cantos Families Team Leader Attachments TSS

==============

-------- Original Message --------

Subject: re: METABOLIFE AND TSEs GAO-03-494 ''URGENT DATA'' 
Date: Thu, 01 May 2003 16:04:35 -0400 
From: "Marcia G Crosse"  
To: CC: "Charles W Davenport" , "Carolyn Feis Korman" , "Martin Gahart"

Mr. Singletary,

We were informed by representatives of Metabolife, Inc. that Metabolife 356 was reformulated to remove bovine complex as an ingredient in the product, approximately September 2001. We did not independently verify the contents of the product.

Sincerely, Marcia Crosse Acting Director Health CarePublic Health and Science Issues U.S. General Accounting Office 441 G Street, N.W. Washington, D.C. 20548

===================

-------- Original Message -------- 
Subject: Re: METABOLIFE AND TSEs GAO-03-494 ''URGENT DATA'' 
Date: Thu, 01 May 2003 15:48:52 -0500 
From: "Terry S. Singeltary Sr." To: Marcia G Crosse CC: Charles W Davenport , Carolyn Feis Korman , Martin Gahart References:

THANK YOU!

MIRACLES DO HAPPEN! ;-)

Thursday, March 19, 2009 

Chronic Wasting Disease Prions in Elk Antler Velvet (Nutritional Supplements and CJD) 


SATURDAY, JANUARY 19, 2019 

Texas Chronic Wasting Disease CWD TSE Prion Symposium 2018 posted January 2019 VIDEO SET 18 CLIPS


MONDAY, JANUARY 14, 2019 

Evaluation of iatrogenic risk of CJD transmission associated with Chronic Wasting Disease TSE Prion in Texas TAHC TPWD

It is a dimension as vast as space and as timeless as infinity. It is the middle ground between light and shadow, between science and superstition, and it lies between the pit of man's fears and the summit of his knowledge. This is the dimension of imagination. It is NOT, an area which we call the Twilight Zone, but an area that believes junk science, and the very industries and lobbyist some Texas Hunters, the cervid industry, that insist on shoving the fake news down their throats, we call this ted nugent junk science, and in TEXAS, sometimes you just can't fix stupid, this is where the rubber meets the road, here's your sign!

chronic wasting disease cwd tse prion aka mad deer elk disease, if you consume a cwd tse prion positive cervid, then months, years, decades later, go on to have surgery, dental, ophthalmology, endoscopy, donate tissue, blood, organs, you then expose those medical theaters and tissue, blood, organs, that are incubating the infectious cwd tse prion disease, to everyone that comes in contact.

these are not memes, these are actual statements from hunters/industry in Texas about CWD tse prion.

God help them, and us...terry

''Got a call today from TPWD, I’ve got a mule deer that tested early positive for CWD. I’m soon to turn into a zombie because I have already been eating it. They advised not to consume any of the meat...too late! They want to come confiscate what meat is left once they get more results back from another lab.''

snip...


terry

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