Missouri MDC 2019-2020 SAMPLING RESULTS CWD TSE PRION TO DATE 28 Positive
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Captive Cervids: Elk, elk-hybrids, red deer, roe deer, sika deer, white-tailed deer, mule deer, moose, and related species in the Cervidae family, raised under confinement or agricultural conditions for the production of meat or other agricultural products or for sport or exhibition, and free-ranging cervidae when they are captured for any purpose.
For information concerning health requirements governing the admission of CWD status herds of Elk, elk-hybrids, red deer, roe deer, sika deer, white-tailed deer, mule deer, moose, and related species in the Cervidae family, sold, traded, exchanged, leased, donated, relinquished or otherwise involved in a change of ownership contact the Division of Animal Health at (573) 751-3377, or e-mail Animal.Health@mda.mo.gov.
https://agriculture.mo.gov/animals/health/disease/deer.php
CWD was first discovered in Missouri in 2010 at a private hunting preserve in Linn County. All cases of CWD in Missouri have been limited to Macon, Linn, and Adair counties, which are part of MDC's six-county CWD Containment Zone. Additional counties included in the zone are Chariton, Randolph, and Sullivan.
http://mdc.mo.gov/newsroom/mdc-reports-two-new-cases-cwd-found-adair-and-macon-counties
hronic Wasting Disease Found in Captive Deer
February 25, 2010
Chronic Wasting Disease Found in Captive Deer The Missouri Departments of Agriculture, Conservation and Health and Senior Services and the U.S. Department of Agriculture announced today that a captive white-tailed deer in Linn County, Missouri has tested positive for Chronic Wasting Disease (CWD). CWD is a neurological disease found in deer, elk and moose.
"There is no evidence that CWD poses a risk to domestic animals or humans," said State Veterinarian Dr. Taylor Woods. "We have protocols in place to quickly and effectively handle these situations."
The animal that tested positive for CWD was a white-tailed deer inspected as part of the State's CWD surveillance and testing program. Preliminary tests were conducted by the USDA National Veterinary Services Laboratory in Ames, Iowa.
Upon receiving the confirmed CWD positive, Missouri's departments of Agriculture, Conservation and Health and Senior Services initiated their CWD Contingency Plan. The plan was developed in 2002 by the Cervid Health Committee, a task force comprised of veterinarians, animal health officers and conservation officers from USDA, MDA, MDC and DHSS working together to mitigate challenges associated with CWD.
CWD is transmitted by live animal to animal contact or soil to animal contact. The disease was first recognized in 1967 in captive mule deer in the Colorado Division of Wildlife captive wildlife research facility in Fort Collins, Colorado. CWD has been documented in deer and/or elk in Colorado, Illinois, Kansas, Michigan, Minnesota, Montana, Nebraska, New Mexico, New York, Oklahoma, South Dakota, Utah, Virginia, West Virginia, Wisconsin, and the Canadian Provinces of Alberta and Saskatchewan. There has been no evidence that the disease can be transmitted to humans.
"Missouri's proactive steps to put a testing protocol in place and create a contingency plan years ago is proving beneficial. We are in a solid position to follow pre-established steps to ensure Missouri's valuable whitetail deer resource remains healthy and strong," said Jason Sumners Missouri's Deer Biologist.
For more information regarding CWD, please contact Dr. Taylor Woods at (573) 751-3377.
https://agriculture.mo.gov/news/newsitem/uuid/21a9e919-c69d-4561-a4e7-70ed4ca8e8ee
Depopulation Plan Being Developed for Captive Deer Facility in Macon County December 30, 2011
Depopulation Plan Being Developed for Captive Deer Facility in Macon County The Missouri Department of Agriculture is finalizing a depopulation and management plan for an approximately 3,000 acre captive wildlife hunting facility in northern Missouri following two positive tests for Chronic Wasting Disease. The facility, operated by Heartland Wildlife Ranches, LLC, is home to white-tail deer, elk and red deer.
The plan includes a requirement to depopulate and test all remaining animals for CWD, as well as restrictions on the future movement of animals into the facility. The plan follows multiple positive CWD tests indentified through random surveillance and extends the facility's current quarantine until all animals have been depopulated and tested for the disease.
In October, MDA received results from the USDA National Veterinary Services Laboratory in Ames, Iowa indicating that a captive white-tail deer harvested in the Macon County facility tested positive for CWD. The animal that tested positive was inspected as part of the State's CWD surveillance and testing program. A second positive test result on a captive white-tail deer within the same facility was verified late this week.
"This plan is an important step forward as we continue working to ensure that this situation is addressed quickly and effectively and that the health of Missouri's cervids is protected from this disease," said State Veterinarian Dr. Linda Hickam.
The State's CWD Contingency Plan was developed in 2002 and revised in 2003 by the Cervid Health Committee, a task force comprised of industry representatives, veterinarians and staff from the departments of Agriculture, Conservation and Health and Senior Services and the U.S. Department of Agriculture.
In February 2010 a case of CWD was confirmed in Linn County on a captive hunting preserve operated by the same entity, Heartland Wildlife Ranches, LLC. The Linn County facility was depopulated and no further infection was identified at that facility.
CWD is transmitted by live animal to animal contact or soil to animal contact. The disease was first recognized in 1967 in captive mule deer in the Colorado Division of Wildlife captive wildlife research facility in Fort Collins, Colorado. CWD has been documented in deer and/or elk in Colorado, Illinois, Kansas, Maryland, Michigan, Minnesota, Montana, Nebraska, New Mexico, New York, North Dakota, Oklahoma, South Dakota, Utah, Virginia, West Virginia, Wisconsin, and the Canadian Provinces of Alberta and Saskatchewan. There has been no evidence that the disease can be transmitted to humans.
CWD is a neurological disease found in deer, elk and moose; it has not been reported in humans or non-cervid animals.
For more information on CWD, visit the Department online at http://www.mda.mo.gov.
https://agriculture.mo.gov/news/newsitem/uuid/d4002ae0-1c23-46cd-b638-d53b221ba6bc
Dept. of Ag Notified of Two Positive Tests for CWD at Macon County Facility March 07, 2012
Dept. of Ag Notified of Two Positive Tests for CWD at Macon County Facility The Missouri Department of Agriculture has received two additional positive test results for Chronic Wasting Disease (CWD) in white-tailed deer harvested at a captive wildlife facility in Macon County. Depopulation is continuing at the facility, operated by Heartland Wildlife Ranches, LLC, with approximately 320 animals harvested and tested since the facility's first positive result was found in October 2011.
MDA has received negative test results for approximately 280 animals, with results pending from the National Veterinary Services Laboratory for the roughly 40 remaining samples. The current harvest and testing protocol requires the facility to remain under its current quarantine until all animals have been harvested and tested for CWD, which is a neurological disease found in deer, elk and moose. There is no evidence CWD can be transmitted to humans or non-cervid animals, such as livestock and household pets.
For more information on CWD visit the Department online at http://www.mda.mo.gov.
https://agriculture.mo.gov/news/newsitem/uuid/3201275b-9cb5-4361-8956-db4f17909b2f
i think some hunters that don't read this carefully are going to think this is a cure all for cwd tse contamination. IT'S NOT!
first off, it would take a strong bleach type sodium hypochlorite, that is NOT your moms bleach she uses in her clothes, and store bought stuff.
Concentrated bleach is an 8.25 percent solution of sodium hypochlorite, up from the “regular bleach” concentration of 5.25 percent.Nov 1, 2013 https://waterandhealth.org/disinfect/high-strength-bleach-2/
second off, the study states plainly;
''We found that a five-minute treatment with a 40% dilution of household bleach was effective at inactivating CWD seeding activity from stainless-steel wires and CWD-infected brain homogenates. However, bleach was not able to inactivate CWD seeding activity from solid tissues in our studies.''
''We initially tested brains from two CWD-infected mice and one uninfected mouse using 40% bleach for 5 minutes. The results from these experiments showed almost no elimination of prion seeding activity (Table 4). We then increased the treatment time to 30 minutes and tested 40% and 100% bleach treatments. Again, the results were disappointing and showed less than a 10-fold decrease in CWD-seeding activity (Table 4). Clearly, bleach is not able to inactivate prions effectively from small brain pieces under the conditions tested here.''
''We found that both the concentration of bleach and the time of treatment are critical for inactivation of CWD prions. A 40% bleach treatment for 5 minutes successfully eliminated detectable prion seeding activity from both CWD-positive brain homogenate and stainless-steel wires bound with CWD. However, even small solid pieces of CWD-infected brain were not successfully decontaminated with the use of bleach.''
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223659
https://chronic-wasting-disease.blogspot.com/2019/10/inactivation-of-chronic-wasting-disease.html
i think with all the fear from recent studies, and there are many, of potential, or likelihood of zoonosis, if it has not already happened as scjd, i think this study came out to help out on some of that fear, that maybe something will help, but the study plainly states it's for sure not a cure all for exposure and contamination of the cwd tse prion on surface materials. imo...terry
172. Establishment of PrPCWD extraction and detection methods in the farm soil
186. Serial detection of hematogenous prions in CWD-infected deer
Our ongoing studies will show whether the transmission of CWD into macaques and passage in transgenic mice represents a form of non-adaptive prion amplification, and whether macaque-adapted prions have the potential to infect mice expressing human PrP.
states.
https://www.nature.com/articles/srep11573
Prion diseases (PD) are the unique neurodegenerative proteinopathies reputed to be transmissible under field conditions since decades. The transmission of Bovine Spongiform Encephalopathy (BSE) to humans evidenced that an animal PD might be zoonotic under appropriate conditions. Contrarily, in the absence of obvious (epidemiological or experimental) elements supporting a transmission or genetic predispositions, PD, like the other proteinopathies, are reputed to occur spontaneously (atpical animal prion strains, sporadic CJD summing 80% of human prion cases).
Non-human primate models provided the first evidences supporting the transmissibiity of human prion strains and the zoonotic potential of BSE. Among them, cynomolgus macaques brought major information for BSE risk assessment for human health (Chen, 2014), according to their phylogenetic proximity to humans and extended lifetime. We used this model to assess the zoonotic potential of other animal PD from bovine, ovine and cervid origins even after very long silent incubation periods.
*** We recently observed the direct transmission of a natural classical scrapie isolate to macaque after a 10-year silent incubation period,
***with features similar to some reported for human cases of sporadic CJD, albeit requiring fourfold long incubation than BSE. Scrapie, as recently evoked in humanized mice (Cassard, 2014),
***is the third potentially zoonotic PD (with BSE and L-type BSE),
***thus questioning the origin of human sporadic cases.
We will present an updated panorama of our different transmission studies and discuss the implications of such extended incubation periods on risk assessment of animal PD for human health.
===============
***thus questioning the origin of human sporadic cases***
===============
***our findings suggest that possible transmission risk of H-type BSE to sheep and human. Bioassay will be required to determine whether the PMCA products are infectious to these animals.
============== https://prion2015.files.wordpress.com/2015/05/prion2015abstracts.pdf
***Transmission data also revealed that several scrapie prions propagate in HuPrP-Tg mice with efficiency comparable to that of cattle BSE. While the efficiency of transmission at primary passage was low, subsequent passages resulted in a highly virulent prion disease in both Met129 and Val129 mice.
***Transmission of the different scrapie isolates in these mice leads to the emergence of prion strain phenotypes that showed similar characteristics to those displayed by MM1 or VV2 sCJD prion.
***These results demonstrate that scrapie prions have a zoonotic potential and raise new questions about the possible link between animal and human prions. http://www.tandfonline.com/doi/abs/10.1080/19336896.2016.1163048?journalCode=kprn20
PRION 2016 TOKYO
Saturday, April 23, 2016
SCRAPIE WS-01: Prion diseases in animals and zoonotic potential 2016
Prion. 10:S15-S21. 2016 ISSN: 1933-6896 printl 1933-690X online
Taylor & Francis
Prion 2016 Animal Prion Disease Workshop Abstracts
WS-01: Prion diseases in animals and zoonotic potential
Transmission of the different scrapie isolates in these mice leads to the emergence of prion strain phenotypes that showed similar characteristics to those displayed by MM1 or VV2 sCJD prion.
These results demonstrate that scrapie prions have a zoonotic potential and raise new questions about the possible link between animal and human prions. http://www.tandfonline.com/doi/abs/10.1080/19336896.2016.1163048?journalCode=kprn20
Title: Transmission of scrapie prions to primate after an extended silent incubation period)
*** In complement to the recent demonstration that humanized mice are susceptible to scrapie, we report here the first observation of direct transmission of a natural classical scrapie isolate to a macaque after a 10-year incubation period. Neuropathologic examination revealed all of the features of a prion disease: spongiform change, neuronal loss, and accumulation of PrPres throughout the CNS.
*** This observation strengthens the questioning of the harmlessness of scrapie to humans, at a time when protective measures for human and animal health are being dismantled and reduced as c-BSE is considered controlled and being eradicated.
*** Our results underscore the importance of precautionary and protective measures and the necessity for long-term experimental transmission studies to assess the zoonotic potential of other animal prion strains. http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=313160
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