Wyoming National Elk Refuge CWD forum update December 8, 2016
CWD forum planned for December 7, 2016
December 8, 2016 Update:
The CWD Forum was held on December 7, with approximately 100 people attending all or part of the presentations. Our sincere thanks to all who attended the forum.
The entire conference was videotaped. Each session title listed in the Schedule section below is a hotlink to view the individual talk. Each video may take a moment to load.
The National Elk Refuge, along with State and other Federal land and wildlife managers and other non-profit organizations, will co-host a Chronic Wasting Disease (CWD) forum on Wednesday, December 7, 2016. The forum will be held at the National Museum of Wildlife Art, located 2.5 miles north of the Town Square in Jackson, Wyoming.
The forum is dedicated to highlighting CWD research and management considerations. The goal of the event is to share current science-based information with the general public and all organizations concerned with the long-term health of area elk and deer populations.
The event is open to the public and free of charge. A $15 lunch will be available for purchase on the day of the event; an evening social includes complimentary hors d'oeuvres and a cash bar.
Attendees need to register for planning purposes. Please use the online registration form provided at this link.
Additional information will be posted here as organizers finalize the schedule and event details. Anyone interested in attending the forum is encouraged to bookmark this web link and check back for updates.
8:00 - 8:30 am
Welcome table: pick up name tags, obtain a printed agenda, ask questions about the forum, etc.
8:30 - 8:45 am
National Elk Refuge Manager Steve Kallin: Welcome and introductions
The morning and afternoon sessions were moderated by Tom Segerstrom, who serves as the Executive Director of the Teton Conservation District. He is a certified wildlife biologist and historically worked in several agencies with important experience in the mining industry. Segerstrom also worked as a Land Steward and Staff Biologist for the Jackson Hole Land Trust for 15 years.
8:45 - 9:30 am
Dr. Mary Wood: Wyoming CWD Surveillance
Dr. Mary Wood is the Wyoming State Wildlife Veterinarian and supervises the Veterinary Services Branch of the Wyoming Game and Fish Department (WGFD). She oversees the Wyoming Game and Fish Wildlife Health Laboratory, wildlife disease surveillance programs, and the Thorne-Williams Wildlife Research Center. Additionally, she participates in both free ranging and captive wildlife disease research across the state with focuses in CWD and respiratory disease in bighorn sheep. Dr. Wood charis the WGFD Chronic Wasting Disease Management team and is actively engaged in regional and international CWD collaborations.
9:30 - 10:15 am
Dr. Davin Henderson: Studies of CWD Transmission and Shedding Using Rapid Sensitive Amplification Assays
Dr. Davin Henderson received his Ph.D. from the University of Minnesota in Biochemistry, Molecular Biology and Biophysics. He is currently a Research Scientist at the Prion Research Center at Colorado State University where he works with Edward Hoover to understand the pathogenesis and replication potential of Chronic Wasting Disease prions affecting deer and elk. He has 5 years of experience working with the RT-QuIC assay and over 15 years of experience in protein biochemistry. He is an author on over 10 manuscripts utilizing the RT-QuIC assay and has pioneered the detection of CWD prions in excreta.
10:15 - 10:30 am
10:30 - 11:15 am
Dr. Joel Pedersen: Soil and Environmental Transmission of CWD
Dr. Joel Pedersen is the Rothermel Bascom Professor of Soil Science at the University of Wisconsin – Madison. He holds appointments in the Departments of Soil Science, Chemistry, and Civil & Environmental Engineering. He is a faculty member in the Environmental Chemistry and Technology program and the Molecular and Environmental Toxicology Center. Prof. Pedersen earned his B.S. degree at University of California Irvine, his M.S. degree at California Institute of Technology, and his doctorate at University of California Los Angeles. The Pedersen research group studies physicochemical and biophysical processes in terrestrial and aquatic environments and has pioneered work in understanding the environmental transmission of prion diseases. His group’s research emphasizes mechanistic studies of the interaction of organic contaminants and macromolecules with environmental interfaces. Prof. Pedersen received the National Science Foundation’s CAREER award and the Early Career Award from ASA-CSSA-SSSA (Agronomy Society of America-Crop Science Society of America-Soil Science Society of America).
11:15 am - 12:00 pm
Amy Girard: Modeling the Effects of CWD on a Rocky Mountain Elk Population Using Genotype-Specific Mortality Rates
Amy Girard recently received her master’s degree from the University of Wyoming through the Department of Animal and Veterinary Sciences. While focused on wildlife disease, she studied the transmission dynamics of the parasite Eleaophora schneideri and the effects of genotype on CWD driven mortality in elk herds of Wyoming. Amy has used her education and interest in wildlife to study a wide variety of species including birds and fish. Prior to graduate school, Amy worked with the Wyoming Game and Fish Department studying brucellosis on elk feedgrounds. Amy currently works with Teton County Weed and Pest.
12:00 - 1:30 pm: Lunch break. A $15 lunch will be available on site.
1:30 - 2:15 pm
Dr. Melia DeVivo: Endemic CWD and Mule Deer Populations Decline in Wyoming
Dr. Melia DeVivo received her bachelor’s and master’s degrees from Indiana University of Pennsylvania, where she studied the habitat use characteristics of parturient elk and survival of calves in northcentral PA. She graduated from the University of Wyoming receiving a Ph.D. in Veterinary Sciences, where she studied the population effects of chronic wasting disease of free ranging mule deer in southeastern Wyoming. Her research has focused on cervid ecology, demography, and disease. Dr. DeVivo is currently working on publications regarding her work on CWD and collaborating with local wildlife and habitat experts on a project for the Jackson Hole Conservation Alliance identifying conservation targets for the Jackson Hole region.
2:15 - 3:00 pm
Nathan Galloway and Jenny Powers: Lessons Learned about CWD in Elk at Rocky Mountain and Wind Cave National Parks
Nathan Galloway joined the Wildlife Health Branch in 2015. He is trained as a microbiologist, a disease ecologist and a Bayesian modeler and attempts to use his diverse background to facilitate conversation between interested collaborators who often lack a common vocabulary. Nathan is concurrently finishing his PhD at Colorado State University on chronic wasting disease in free-ranging populations and is thrilled to have the opportunity with the NPS to contribute to knowledge about the dynamics and management of wildlife diseases. When not analyzing data and discussing the community ecology of wildlife disease, Nathan can be found riding his bike, hiking, and trying to pay attention to the worthwhile.
Jenny Powers joined the National Park Service Wildlife Health program in 2002 as a wildlife veterinarian. With a background in large animal medicine and reproductive physiology, Jenny works with parks on wildlife health issues ranging from capture and anesthesia projects to disease outbreak investigations. She has studied chronic wasting disease (CWD) related questions from both management and research perspectives since joining the NPS. As the CWD coordinator for the NPS Jenny has assisted parks to learn about the epidemiology, ecology, and transmission of the disease as well as develop deer and elk management plans which accommodate CWD surveillance, disinfection, and disposal. Jenny received her DVM from the University of California, Davis and her PhD from Colorado State University. She enjoys working through "thorny" wildlife management problems with a variety of state, federal, university, and other conservation partners.
3:00 - 3:15 pm
3:15 - 4:00 pm
Dr. Tom Hobbs: Using Models and Data to Support Adaptive Management of the Jackson Elk Herd
Dr. Tom Hobbs has worked on population and community ecology of large mammals for the last three decades. Virtually all of his work uses models of ecological process to gain insight from data. He has particular expertise in building demographic models on populations, models that now widely used to support management and policy in North America and Europe. He has been on the faculty at Colorado State since 2001 and before that he worked for 20 years as a research scientist for Colorado Division of Wildlife. He has served as a rotating Program Director in the Population and Community Ecology Cluster of the Division of Environmental Biology at the National Science Foundation. He is a member of the Editorial Board of Ecological Applications. Princeton University Press recently published his book (co-authored with Mevin Hooten), Bayesian Modeling: a Statistical Primer for Ecologists. Tom has a degree in general biology from Grinnell College and an MS. and Ph.D. in wildlife ecology from Colorado State University.
4:00 - 4:45 pm
Dr. Chad Bishop: Role of Habitat Treatments and Related Mitigation Strategies to Offset Impacts of Altered Feedground Management
Chad Bishop is Director of the Wildlife Biology Program at University of Montana. As Director, Chad is responsible for a wide array of functions tied to running the Program, with an emphasis on faculty and student support and Program outreach and development. He received a Bachelor’s of Science degree in Biology (Fish and Wildlife Management Option) from Montana State University (1995), a Master’s of Science degree in Wildlife Resources from University of Idaho (1998), and a Doctorate degree in Wildlife Biology from Colorado State University (2007). Prior to University of Montana, he spent nearly 16 years working for Colorado Division of Wildlife (now Colorado Parks and Wildlife), where he held positions as an ungulate researcher (1999-2009), Mammals Research Leader (2009-2012), and Assistant Director (2012-2015).
4:45 - 6:30 pm: Social Hour; hors d'oeuvres and cash bar provided.
6:30 - 8:00 pm
Round Table Discussion, moderated by John Turner
Among his many accomplishments, John Turner served as the Director of the U.S. Fish and Wildlife Service from 1989-1993 and Assistant Secretary of State for the Bureau of Oceans and International Environmental and Scientific Affairs from 2001 through 2005. Turner received a Master of Science degree in Wildlife Ecology from the University of Michigan and a Bachelor of Arts degree in Biology from the University of Notre Dame. A native of Moose, Wyoming, Turner is a third-generation rancher who, with his brothers, operates the Triangle X Ranch in Grand Teton National Park.
SEE VIDEOS ;
December 7, 2016
Dr. Mary Wood
Jackson Hole Chronic Wasting Disease Forum
December 7, 2016
Dr. Davin Henderson
December 7, 2016
*** Dr. Melia Devivo ***
December 7, 2016
Dr. Chad Bishop
Jackson Hole Chronic Wasting Disease Forum
December 7, 2016
Dr. Joel Pedersen
Jackson Hole Chronic Wasting Disease Forum
December 7, 2016
7 Dr Powers:Galloway
8 Dr Tom Hobbs
9 Dr Chad Bishop
10 Evening Presentation
please remember, to date ;
Clay Components in Soil Dictate Environmental Stability and Bioavailability of Cervid Prions in Mice
Wednesday, December 14, 2016
We found that CWD adapts to a new host more readily than BSE and that human PrP was unexpectedly prone to misfolding by CWD prions. In addition, we investigated the role of specific regions of the bovine, deer and human PrP protein in resistance to conversion by prions from another species. We have concluded that the human protein has a region that confers unusual susceptibility to conversion by CWD prions.
Student Presentations Session 2
The species barriers and public health threat of CWD and BSE prions
Ms. Kristen Davenport1, Dr. Davin Henderson1, Dr. Candace Mathiason1, Dr. Edward Hoover1 1Colorado State University
Chronic wasting disease (CWD) is spreading rapidly through cervid populations in the USA. Bovine spongiform encephalopathy (BSE, mad cow disease) arose in the 1980s because cattle were fed recycled animal protein. These and other prion diseases are caused by abnormal folding of the normal prion protein (PrP) into a disease causing form (PrPd), which is pathogenic to nervous system cells and can cause subsequent PrP to misfold. CWD spreads among cervids very efficiently, but it has not yet infected humans. On the other hand, BSE was spread only when cattle consumed infected bovine or ovine tissue, but did infect humans and other species. The objective of this research is to understand the role of PrP structure in cross-species infection by CWD and BSE. To study the propensity of each species’ PrP to be induced to misfold by the presence of PrPd from verious species, we have used an in vitro system that permits detection of PrPd in real-time. We measured the conversion efficiency of various combinations of PrPd seeds and PrP substrate combinations. We observed the cross-species behavior of CWD and BSE, in addition to feline-adapted CWD and BSE. We found that CWD adapts to a new host more readily than BSE and that human PrP was unexpectedly prone to misfolding by CWD prions. In addition, we investigated the role of specific regions of the bovine, deer and human PrP protein in resistance to conversion by prions from another species. We have concluded that the human protein has a region that confers unusual susceptibility to conversion by CWD prions. CWD is unique among prion diseases in its rapid spread in natural populations. BSE prions are essentially unaltered upon passage to a new species, while CWD adapts to the new species. This adaptation has consequences for surveillance of humans exposed to CWD.
Wildlife Disease Risk Communication Research Contributes to Wildlife Trust Administration Exploring perceptions about chronic wasting disease risks among wildlife and agriculture professionals and stakeholders
PRION 2016 TOKYO
Zoonotic Potential of CWD Prions: An Update
Ignazio Cali1, Liuting Qing1, Jue Yuan1, Shenghai Huang2, Diane Kofskey1,3, Nicholas Maurer1, Debbie McKenzie4, Jiri Safar1,3,5, Wenquan Zou1,3,5,6, Pierluigi Gambetti1, Qingzhong Kong1,5,6 1Department of Pathology, 3National Prion Disease Pathology Surveillance Center, 5Department of Neurology, 6National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. 4Department of Biological Sciences and Center for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada, 2Encore Health Resources, 1331 Lamar St, Houston, TX 77010
Chronic wasting disease (CWD) is a widespread and highly transmissible prion disease in free-ranging and captive cervid species in North America. The zoonotic potential of CWD prions is a serious public health concern, but the susceptibility of human CNS and peripheral organs to CWD prions remains largely unresolved. We reported earlier that peripheral and CNS infections were detected in transgenic mice expressing human PrP129M or PrP129V. Here we will present an update on this project, including evidence for strain dependence and influence of cervid PrP polymorphisms on CWD zoonosis as well as the characteristics of experimental human CWD prions.
PRION 2016 TOKYO In Conjunction with Asia Pacific Prion Symposium 2016 PRION 2016 Tokyo Prion 2016
Cervid to human prion transmission
Case Western Reserve University, Cleveland, OH, United States
Prion disease is transmissible and invariably fatal. Chronic wasting disease (CWD) is the prion disease affecting deer, elk and moose, and it is a widespread and expanding epidemic affecting 22 US States and 2 Canadian provinces so far. CWD poses the most serious zoonotic prion transmission risks in North America because of huge venison consumption (>6 million deer/elk hunted and consumed annually in the USA alone), significant prion infectivity in muscles and other tissues/fluids from CWD-affected cervids, and usually high levels of individual exposure to CWD resulting from consumption of the affected animal among often just family and friends. However, we still do not know whether CWD prions can infect humans in the brain or peripheral tissues or whether clinical/asymptomatic CWD zoonosis has already occurred, and we have no essays to reliably detect CWD infection in humans. We hypothesize that:
(1) The classic CWD prion strain can infect humans at low levels in the brain and peripheral lymphoid tissues;
(2) The cervid-to-human transmission barrier is dependent on the cervid prion strain and influenced by the host (human) prion protein (PrP) primary sequence;
(3) Reliable essays can be established to detect CWD infection in humans;and
(4) CWD transmission to humans has already occurred. We will test these hypotheses in 4 Aims using transgenic (Tg) mouse models and complementary in vitro approaches.
Aim 1 will prove that the classical CWD strain may infect humans in brain or peripheral lymphoid tissues at low levels by conducting systemic bioassays in a set of "humanized" Tg mouse lines expressing common human PrP variants using a number of CWD isolates at varying doses and routes. Experimental "human CWD" samples will also be generated for Aim 3.
Aim 2 will test the hypothesis that the cervid-to-human prion transmission barrier is dependent on prion strain and influenced by the host (human) PrP sequence by examining and comparing the transmission efficiency and phenotypes of several atypical/unusual CWD isolates/strains as well as a few prion strains from other species that have adapted to cervid PrP sequence, utilizing the same panel of humanized Tg mouse lines as in Aim 1.
Aim 3 will establish reliable essays for detection and surveillance of CWD infection in humans by examining in details the clinical, pathological, biochemical and in vitro seeding properties of existing and future experimental "human CWD" samples generated from Aims 1-2 and compare them with those of common sporadic human Creutzfeldt-Jakob disease (sCJD) prions.
Aim 4 will attempt to detect clinical CWD-affected human cases by examining a significant number of brain samples from prion-affected human subjects in the USA and Canada who have consumed venison from CWD-endemic areas utilizing the criteria and essays established in Aim 3. The findings from this proposal will greatly advance our understandings on the potential and characteristics of cervid prion transmission in humans, establish reliable essays for CWD zoonosis and potentially discover the first case(s) of CWD infection in humans.
Public Health Relevance There are significant and increasing human exposure to cervid prions because chronic wasting disease (CWD, a widespread and highly infectious prion disease among deer and elk in North America) continues spreading and consumption of venison remains popular, but our understanding on cervid-to-human prion transmission is still very limited, raising public health concerns. This proposal aims to define the zoonotic risks of cervid prions and set up and apply essays to detect CWD zoonosis using mouse models and in vitro methods. The findings will greatly expand our knowledge on the potentials and characteristics of cervid prion transmission in humans, establish reliable essays for such infections and may discover the first case(s) of CWD infection in humans.
Funding Agency Agency National Institute of Health (NIH)
Institute National Institute of Neurological Disorders and Stroke (NINDS)
Type Research Project (R01)
Project # 1R01NS088604-01A1
Application # 9037884
Study Section Cellular and Molecular Biology of Neurodegeneration Study Section (CMND)
Program Officer Wong, May
Project Start 2015-09-30
Project End 2019-07-31
Budget Start 2015-09-30
Budget End 2016-07-31
Support Year 1
Fiscal Year 2015
Total Cost $337,507
Indirect Cost $118,756
Name Case Western Reserve University
Type Schools of Medicine
DUNS # 077758407
Country United States
Zip Code 44106
*** Zoonotic Potential of CWD Prions: An Update Prion 2016 Tokyo ***
why do we not want to do TSE transmission studies on chimpanzees $
5. A positive result from a chimpanzee challenged severly would likely create alarm in some circles even if the result could not be interpreted for man. I have a view that all these agents could be transmitted provided a large enough dose by appropriate routes was given and the animals kept long enough. Until the mechanisms of the species barrier are more clearly understood it might be best to retain that hypothesis.
SCRAPIE WS-01: Prion diseases in animals and zoonotic potential 2016
Prion. 10:S15-S21. 2016 ISSN: 1933-6896 printl 1933-690X online
Thursday, June 09, 2016
Scrapie Field Trial Experiments Mission, Texas, The Moore Air Force Base Scrapie TSE Prion Experiment 1964
Thursday, December 08, 2016
USDA APHIS National Scrapie Eradication Program October 2016 Monthly Report Fiscal Year 2017 atypical NOR-98 Scrapie
Susceptibility of domestic cats to chronic wasting disease
Amy V.Nalls,1 Candace Mathiason,1 Davis Seelig,2 Susan Kraft,1 Kevin Carnes,1 Kelly Anderson,1 Jeanette Hayes-Klug1 and Edward A. Hoover1 1Colorado State University; Fort Collins, CO USA; 2University of Minnesota; Saint Paul, MN USA
Domestic and nondomestic cats have been shown to be susceptible to feline spongiform encephalopathy (FSE), almost certainly caused by consumption of bovine spongiform encephalopathy (BSE)-contaminated meat. Because domestic and free-ranging nondomestic felids scavenge cervid carcasses, including those in areas affected by chronic wasting disease (CWD), we evaluated the susceptibility of the domestic cat (Felis catus) to CWD infection experimentally. Cohorts of 5 cats each were inoculated either intracerebrally (IC) or orally (PO) with CWD-infected deer brain. At 40 and 42 mo post-inoculation, two IC-inoculated cats developed signs consistent with prion disease, including a stilted gait, weight loss, anorexia, polydipsia, patterned motor behaviors, head and tail tremors, and ataxia, and progressed to terminal disease within 5 mo. Brains from these two cats were pooled and inoculated into cohorts of cats by IC, PO, and intraperitoneal and subcutaneous (IP/SC) routes. Upon subpassage, feline-adapted CWD (FelCWD) was transmitted to all IC-inoculated cats with a decreased incubation period of 23 to 27 mo. FelCWD was detected in the brains of all the symptomatic cats by western blotting and immunohistochemistry and abnormalities were seen in magnetic resonance imaging, including multifocal T2 fluid attenuated inversion recovery (FLAIR) signal hyper-intensities, ventricular size increases, prominent sulci, and white matter tract cavitation. Currently, 3 of 4 IP/SQ and 2 of 4 PO inoculared cats have developed abnormal behavior patterns consistent with the early stage of feline CWD.
*** These results demonstrate that CWD can be transmitted and adapted to the domestic cat, thus raising the issue of potential cervid-to- feline transmission in nature.
PO-081: Chronic wasting disease in the cat— Similarities to feline spongiform encephalopathy (FSE)
new link ;
FELINE SPONGIFORM ENCEPHALOPATHY FSE
3 further cheetah cases have occured, plus 1 lion, plus all the primates, and 20 additional house cats. Nothing has been published on any of these UK cases either. One supposes the problem here with publishing is that many unpublished cases were _born_ long after the feed "ban". Caught between a rock and a hard place: leaky ban or horizontal transmission (or both).
Monday, February 14, 2011
THE ROLE OF PREDATION IN DISEASE CONTROL: A COMPARISON OF SELECTIVE AND NONSELECTIVE REMOVAL ON PRION DISEASE DYNAMICS IN DEER NO, NO, NOT NO, BUT CensoredCensoredCensoredCensored NO !
Journal of Wildlife Diseases, 47(1), 2011, pp. 78-93 © Wildlife Disease Association 2011
Wyoming CWD Report monitoring efforts increase with focus on improving herd health
Thursday, November 17, 2016
Wyoming Game and Fish Department confirmed CWD Deer Hunt Area 110 west of Cody
Wednesday, November 09, 2016
Wyoming Game and Fish Department confirmed chronic wasting disease (CWD) in Deer Hunt Area 121, near Heart Mountain
Tuesday, October 18, 2016
WYOMING Game and Fish finds CWD in new deer hunt area near Dubois and will more actively monitor elk feedgrounds
Sunday, October 16, 2016
Wyoming Game and Fish finds CWD in new deer hunt area near Osage
Tuesday, June 07, 2016
Wyoming For the first time in several years an ungulate has tested positive for Chronic Wasting Disease (CWD) on the west side of the continental divide
Wednesday, April 27, 2016
WYOMING GAME AND FISH DEPARTMENT CHRONIC WASTING DISEASE MANAGEMENT PLAN APRIL 22, 2016
Thursday, March 10, 2016
WYOMING RIDE EM COWBOY HELICOPTER WRANGLING RAMBO STYLE DEER BULLDOGGING RODEO FOR CWD VIDEO
Monday, March 07, 2016
Wyoming Game and Fish Department confirmed chronic wasting disease (CWD) in a buck mule deer that was found dead southeast of Lander
Tuesday, January 12, 2016
Wyoming Game and Fish seeks additional public comments on draft of updated CWD plan Singeltary 2nd submission
From: Terry S. Singeltary Sr.
Sent: Tuesday, January 12, 2016 3:52 PM
Cc: Tara.Hodges@wyo.gov ; email@example.com ; Carrie.Little@wyo.gov
Subject: Game and Fish seeks additional public comments on draft of updated CWD plan Singeltary 2nd submission
Wednesday, December 14, 2016
Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples
Terry S. Singeltary Sr.