Norway Chronic Wasting Disease CWD TSE Prion Skrantesjuke 2 Positive Moose for 2019
Norway Chronic Wasting Disease CWD TSE Prion Skrantesjuke 2 Positive Moose for 2019
(please note, this was translated by internet, so there ya go...terry)
Results of the Tranquility Survey (CWD) in 2019
Published 01.04.2020
In total, the Veterinary Institute has tested 30,147 deer in the surveillance program for CWD in 2019. Of these, two moose (wild) tested positive for atypical sepsis. One of these was found dead in Sigdal municipality in southern Norway, the other was from hunting in Selbu municipality in central Norway.
At the Veterinary Institute's lab for prion diseases. The CWD samples must go through a number of processes before they can be analyzed. Here the samples are made fluid and can be further processed. Photo: Mari M. Press, Veterinary Institute
A large proportion of the animals that have been tested (43%) have been domesticated. In addition, 5932 elk, 5751 deer, 3335 wild reindeer, 5751 deer and 37 deer were tested. Just under 500 have been animals of unknown origin. In addition, four wild reindeer from Svalbard have been tested and 37 mosquitoes from Dovre have been tested for prion disease outside the surveillance program. With the exception of the two moose, all samples were negative in 2019.
Briefly on the monitoring program
Prion disease CWD is a disease in the group of transmissible (spongiform) encephalopathies (TSEs), which causes destruction of mammalian brain tissue with fatal outcome. The goal of the CWD surveillance program is to detect the incidence of deer disease for deer, both domestic and wild animals. There has been annual testing and monitoring of CWD since 2002. Monitoring of CWD takes place on behalf of MT. The first detection of scabies in Europe took place at the wild reindeer in the Nordfjella wild reindeer area in southern Norway (March 2016). This was the first detection of deer disease in reindeer in the world.
Link to OK report
Link to facts about CWD
Jørn Våge Researcher of wildness, sickness / CWD coordinator Mobile no .: +47 93413615 E-mail: jorn.vage@vetinst.no
New case of moose sickness 16.11.2019 18:59:08 CET | FSA
Test results from a self-killed elk found in Sigdal show that the animal had scabies (CWD).
This is the sixth case of moose disease in moose in Norway. The first five have been of the type of atypical tranquilizer that is considered not infectious. There were moose hunters who came randomly over the dead animal and who reported to the game manager in the municipality. Brain material was submitted to the Veterinary Institute for testing and this resulted in ailment. In animals with atypical scabies, we do not find any infectious agent in the lymph nodes, nor was it done in the head lymph nodes from this moose. The Norwegian Food Safety Authority now sends the rest of the animal to the Veterinary Institute for further testing.
Report whether you see sick or dead deer Since its inception in 2016, over 94,000 deer have been tested for aphid disease. The Norwegian Food Safety Authority encourages anyone traveling in the woods and fields to see sick or dead deer to report to the Food Safety Authority. Symptoms of jaundice are emaciation, frequent urination and abnormal behavior, such as animals not shaming humans. The disease is deadly to deer, but has never been shown to infect humans, either from animals or meat.
Two variants of the apex There are two variants of the apex, one infectious variant and one variant which we assume is not contagious. The infectious variant is only found on wild reindeer in Nordfjella. Atypical ridge disease has previously been found on five moose; three in Selbu, one in Lierne and one in Flesberg, in addition to a deer in Gjemnes.
CIDRAP CWD Resource Center: http://www.cidrap.umn.edu/cwd
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Norway CWD Moose Dr. Debbie McKenzie
cwd strains
cwd in Moose in Norway are very different than moose here (USA).
when we look at the brains of cwd moose in Norway, it has a completely different distribution than what's been seen in North America.
the numbers in North America are very low, So we really don't have any idea if there could be similarities.
Ah...we have passaged one of the moose samples in our transgenic mice, and...from Norway, and it goes down faster than anything else we've seen. so it suggest that its different than anything else in North America.
it's suggesting it's coming from a different source, so it's not like North america CWD got to Norway, and we just don't know enough about that moose.
snip...end...see video;
https://www.youtube.com/watch?v=xzYcnmc3Xh0&feature=youtu.be&fbclid=IwAR1zPTQ-jHQumn_gudIg3xHGVkBDh_Q330nPq023jgYTgPZ2a2QH5PcvtIE
Greetings again Professor McKenzie,
snip...
the reason i write Ma'am, a bit of confusion, on your presentation, around the 46:30 to 47:40 of your presentation, i have some folks from Norway asking;
''Listen to Debbie McKenzie talking about this CWD strain om moose from 46:30 to 47:40. I don't understand what she mean''
so i went back and listened again, and this is what i transcribed;
i think what they are confused about is this line;
''Ah...we have passaged one of the moose samples in our transgenic mice, and...from Norway, and it goes down faster than anything else we've seen.''
what does this mean please, a bit more detail???
comment from Debbie McKenzie today about this, and many thanks for her comment and work on the tse prion;
''What I meant by that comment was that when we passaged the moose sample from Norway in our transgenic mouse models, the mice presented with clinical disease faster than any of the other CWD agents we have passaged in those mice. I would need to check with lab people as to the particular mouse line. We have passaged dozens of CWD agents in our mouse lines and were somewhat surprised how quickly they presented with disease when infected with Norwegian moose. This further confirms that the moose CWD in Norway is different from deer CWD in North America. We haven't passaged other moose samples (i.e., North American ones) so can't say, based on our data, that Norwegian moose is different than NA moose---but I think Sylvie and Terry Spraker have nicely demonstrated this already''...end...tss
NYTT TILFELLE AV SKRANTESJUKE PÅ ELG
16.11.2019
Prøveresultater fra en selvdød elg funnet i Sigdal viser at dyret hadde skrantesjuke (CWD).
Det sjette tilfellet av skrantesjuke hos elg er oppdaget i Norge. Trolig dreier det seg også denne gangen om atypisk skrantesjuke. Arkivfoto: Erling J. Solberg, NINA
Dette er det sjette tilfellet av skrantesjuke hos elg i Norge. De fem første har vært av typen atypisk skrantesjuke som blir ansett ikke å smitte. Det var elgjegere som kom tilfeldig over det døde dyret og som meldte fra til viltforvalter i kommunen. Hjernemateriale ble sendt inn til Veterinærinstituttet for testing, og det ga utslag på skrantesjuke. Hos dyr med atypisk skrantesjuke finner vi ikke smittestoff i lymfeknutene, og det ble det heller ikke gjort i hodelymfeknutene fra denne elgen. Mattilsynet sender nå resten av dyret inn til Veterinærinstituttet for videre testing.
Meld fra om du ser syke eller døde hjortedyr
Siden starten i 2016 er over 94 000 hjortedyr testet for skrantesjuke. Mattilsynet oppfordrer alle som ferdes i skog og mark og ser syke eller døde hjortedyr om å melde fra til Mattilsynet. Symptomer på skrantesjuke er avmagring, hyppig urinering og unormal oppførsel, for eksempel at dyr ikke skyr mennesker.
Sykdommen er dødelig for hjortedyr, men har aldri vist seg å smitte til mennesker, hverken fra dyr eller kjøtt.
To varianter av skrantesjuke
Det finnes to varianter av skrantesjuke, en smittsom variant og en variant som vi antar ikke er smittsom. Den smittsomme varianten er kun funnet på villrein i Nordfjella. Atypisk skrantesjuke er fra før blitt funnet på fem elger; tre i Selbu, en i Lierne og en i Flesberg, i tillegg til en hjort i Gjemnes.
The new type of chronic illness (Chronic Wasting Disease, CWD) has been called Nor16CWD. The article contains a description of the three cases of CWD found on moose in Norway and how they are different from those of reindeer, CWD in North America and other prion diseases in animals.
In the understanding of discoveries in Norwegian moose, we build on knowledge of similar disease in cattle (BSE) and sheep (scrapie disease). In these animals there is variety that makes us distinguish between classic and atypical disease. The Veterinary Institute, with Benestad, was central to the discovery of atypical scrapie disease in sheep, named Nor98 after discovery this year. This is a disease that has not been contagious, such as classic scrapie. In cattle, atypical bullet disease (BSE) was discovered in 2003. Atypical BSE and Nor98 are thought to occur spontaneously, especially in older animals. Knowledge of variation in prion diseases has led to different management and management of the different types.
- Since we now gain new knowledge about variation in this disease group also in our deer animals, it can have consequences for future professional councils, and management says senior scientist Sylvie Benestad.
Different clearly from other CWD types The new discovery Nor16CWD is shown, among other things, by the way the misfolded prion protein is distributed in the brain of the moose. This is clearly different from the other CWD types. The structure of the protein itself is also different. Nor16CWD has been detected only in the brain and not in lymph nodes, which is common with other types of CWD. The moose have been 13-14 years old, while other types of CWD are found on far younger animals. In the case of Norwegian wild reindeer and deer in North America, CWD has been contagious. Such a characteristic of classic CWD is probably linked to the distribution of infectious agents to lymph nodes in the body, in addition to the brain. Based on the work done in connection with this article, it is not possible to say whether the new type of CWD in elk is contagious between deer. Number of moose tested,
Behind the scientific publication is a wide-ranging international team of researchers from Italy, Norway, the United States, Canada, and France.
Read article
A novel type of Chronic Wasting Disease detected in European moose ( Alces alces ) in Norway
Volume 24, Number 12—December 2018 Research Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway
Incomplete inactivation of atypical scrapie following recommended autoclave decontamination procedures
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/tbed.13247
Summary
Prions are highly resistant to the decontamination procedures normally used to inactivate conventional pathogens. This is a challenging problem not only in the medical and veterinary fields for minimising the risk of transmission from potentially infective sources, but also for ensuring the safe disposal or subsequent use of animal by‐products. Specific pressure autoclaving protocols were developed for this purpose, but different strains of prions have been reported to have differing resistance patterns to established prion decontamination procedures, and as additional TSE strains are identified it is necessary to determine the effectiveness of such procedures. In this study we assessed the efficacy of sterilisation using the EU recommended autoclave procedure for prions (133o C, 3 Bar for 20 min) on the atypical or Nor98 (AS/Nor98) scrapie strain of sheep and goats. Using a highly sensitive murine mouse model (tg338) that overexpresses ovine PrPC, we determined that this method of decontamination reduced the infectivity titre by 1010. Infectivity was nonetheless still detected after applying the recommended autoclaving protocol. This shows that AS/Nor98 can survive the designated legislative decontamination conditions, albeit with a significant decrease in titre. The infectivity of a classical scrapie isolate subjected to the same decontamination conditions was reduced by 106 suggesting that the AS/Nor98 isolate is less sensitive to decontamination than the classical scrapie source.
This article is protected by copyright. All rights reserved.
A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes
Annick Le Dur*,?, Vincent Béringue*,?, Olivier Andréoletti?, Fabienne Reine*, Thanh Lan Laï*, Thierry Baron§, Bjørn Bratberg¶, Jean-Luc Vilotte?, Pierre Sarradin**, Sylvie L. Benestad¶, and Hubert Laude*,?? +Author Affiliations
*Virologie Immunologie Moléculaires and ?Génétique Biochimique et Cytogénétique, Institut National de la Recherche Agronomique, 78350 Jouy-en-Josas, France; ?Unité Mixte de Recherche, Institut National de la Recherche Agronomique-Ecole Nationale Vétérinaire de Toulouse, Interactions Hôte Agent Pathogène, 31066 Toulouse, France; §Agence Française de Sécurité Sanitaire des Aliments, Unité Agents Transmissibles Non Conventionnels, 69364 Lyon, France; **Pathologie Infectieuse et Immunologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France; and ¶Department of Pathology, National Veterinary Institute, 0033 Oslo, Norway
***Edited by Stanley B. Prusiner, University of California, San Francisco, CA (received for review March 21, 2005)
Abstract
Scrapie in small ruminants belongs to transmissible spongiform encephalopathies (TSEs), or prion diseases, a family of fatal neurodegenerative disorders that affect humans and animals and can transmit within and between species by ingestion or inoculation. Conversion of the host-encoded prion protein (PrP), normal cellular PrP (PrPc), into a misfolded form, abnormal PrP (PrPSc), plays a key role in TSE transmission and pathogenesis. The intensified surveillance of scrapie in the European Union, together with the improvement of PrPSc detection techniques, has led to the discovery of a growing number of so-called atypical scrapie cases. These include clinical Nor98 cases first identified in Norwegian sheep on the basis of unusual pathological and PrPSc molecular features and "cases" that produced discordant responses in the rapid tests currently applied to the large-scale random screening of slaughtered or fallen animals. Worryingly, a substantial proportion of such cases involved sheep with PrP genotypes known until now to confer natural resistance to conventional scrapie. Here we report that both Nor98 and discordant cases, including three sheep homozygous for the resistant PrPARR allele (A136R154R171), efficiently transmitted the disease to transgenic mice expressing ovine PrP, and that they shared unique biological and biochemical features upon propagation in mice.
*** These observations support the view that a truly infectious TSE agent, unrecognized until recently, infects sheep and goat flocks and may have important implications in terms of scrapie control and public health.
OR
***The pathology features of Nor98 in the cerebellum of the affected sheep showed similarities with those of sporadic Creutzfeldt-Jakob disease in humans.
OR
*** Intriguingly, these conclusions suggest that some pathological features of Nor98 are reminiscent of Gerstmann-Sträussler-Scheinker disease.
OR here;
MONDAY, NOVEMBER 18, 2019
Norway Chronic Wasting Disease CWD TSE Prion Detected in Sixth Moose
TSS
posted by Terry S. Singeltary Sr. at
4:48 PM
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