Norway Skrantesjuke CWD TSE Prion detected on reindeer buck from Hardangervidda
Skrantesjuke detected on reindeer buck from Hardangervidda
On Thursday evening, the Veterinary Institute notified the Norwegian Food Safety Authority of a confirmed case of scrapie in a wild reindeer field during ordinary hunting on the Hardangervidda. Lymph node material tested positive, while brain tissue was devoid of findings.
This is the first case of classic scrapie that has been detected outside Nordfjella zone 1, where the disease was first detected in 2016. Later, the wild reindeer strain in this zone was removed to prevent the spread of infection. In Norway, classical scrapie has previously only been detected in wild reindeer from Nordfjella zone 1.
At least two types of scrapie prions have been discovered in Norway. In wild reindeer, it has been contagious (classic scrapie) in contrast to seven cases in moose and one deer where it has probably occurred spontaneously in older animals (atypical scrapie). Scrapie is a deadly prion disease for deer, but has never been detected in humans.
The wild reindeer was felled south of the Hardangervidda in Vinje municipality.
Report if you see sick or dead deer
Since the start in 2016, more than 100,000 deer have been tested for scrapie. From the Hardangervidda, samples from 3520 wild reindeer have been tested, all so far without any findings of scrapie. Of these, 518 wild reindeer from the Hardangervidda were tested in 2020 without findings, see statistics.
Symptoms of scrapie are weight loss, frequent urination and abnormal behavior, e.g. animals that do not shy away from humans.
https://www.nrk.no/vestland/har-funne-skrantesjuke-hja-villrein-pa-hardangervidda-1.15156665
Confirmed finding of scrapie on the Hardangervidda
11.9.2020 09:31:08 CEST | The Norwegian Food Safety Authority
Scrapie (CWD) has been detected in a wild reindeer buck shot while hunting on the Hardangervidda. This is the first time that the classic, and contagious, variant of scrapie has been found outside Nordfjella...See;
Bekreftet funn av skrantesjuke på Hardangervidda 11.9.2020 09:31:08 CEST | Mattilsynet
Del Det er påvist skrantesjuke (CWD) på en villreinbukk skutt under jakt på Hardangervidda. Det er første gang den klassiske, og smittsomme, varianten av skrantesjuke er funnet utenfor Nordfjella.
Slik så slakteplassen ut før Mattilsynet og Statens Naturoppsyn fjernet slakteavfall og vegetasjon. Foto: Mattilsynet Slik så slakteplassen ut før Mattilsynet og Statens Naturoppsyn fjernet slakteavfall og vegetasjon. Foto: Mattilsynet Mattilsynet ble varslet av Veterinærinstituttet om påvisningen torsdag kveld.
– Dette er alvorlig for den norske villreinbestanden, sier Ingunn Midttun Godal, administrerende direktør i Mattilsynet.
Etter skrantesjuke første gang ble påvist i Norge i 2016, har norske myndigheter hatt et ambisiøst mål om å bli kvitt denne alvorlige dyresykdommen.
– Siden 2016 har det blitt lagt ned en omfattende innsats av myndigheter, jegere, bønder, villreinforvaltning og mange andre for å hindre videre spredning av skrantesjuke. Dette gjør vi for å sikre friske bestander av villrein og andre hjortedyr i fremtiden, sier Godal.
Det er ikke kjent hvordan reinsdyret har blitt smittet, altså om smitten har spredt seg fra Nordfjella eller om reinsdyret har blitt smittet på annet vis. Sykdommen er dødelig for dyr, men har ikke blitt påvist hos mennesker. Det er svært liten risiko for at sykdommen skal smitte til mennesker, men for å være på den sikre siden, godkjenner Mattilsynet ikke at kjøtt fra dyr som tester positivt skal spises.
– Vi forstår at mange jegere og andre nå blir bekymret. Årets jakt er godt i gang og i denne situasjonen er det ekstra viktig at jegerne fortsetter den utrolig viktige jobben de gjør med å sende inn prøver, slik at vi får mer kunnskap om situasjonen på Hardangervidda, sier Godal.
Viktig informasjon til jegere på Hardangervidda
Jegere på Hardangervidda må notere posisjonen på fellingssteder, slik at Mattilsynet kan spore slakterester, dersom det viser seg at dyret er smittet. Jegerne må også være flinke til å grave eller stene ned slakterestene. Dersom dyret viser seg å være smittet, vil Mattilsynet kontakte jeger. Mattilsynet vil komme tilbake med mer informasjon til jegere i dette området.
Hva skjer framover?
Mattilsynet har vært i kontakt med jegeren som har skutt bukken. Medarbeidere fra Mattilsynet og Miljødirektoratet, ved Statens Naturoppsyn, er på vei ut til slakteplassen som ligger sentralt, sør på Hardangervidda i Vinje kommune, for å hente inn rester av dyret. Det er viktig å fjerne alle restene fra dyret som kan inneholde smitte.
I Nordfjella ble hele villreinstammen avlivet for å hindre utbredelse av den smittsomme sykdommen.
– Når vi nå har oppdaget et tilfelle utenfor Nordfjella, er situasjonen en annen, og vi må vurdere hvilke tiltak som skal gjøres fremover, sier Godal.
Jegere bidrar til et omfattende kartleggingsprogram
Siden 2016 har det blitt analysert over 100 000 prøver av hjortedyr, uten funn av denne varianten utenfor Nordfjella. Det har blitt analysert over 3 500 prøver fra Hardangervidda, 518 så langt fra årets jakt.
– Det er for tidlig å si hvordan funnet vil påvirke strategien for bekjempelse av sykdommen, men ønsket om å sikre friske bestander av villrein og andre hjortedyr i fremtiden står fast, sier Ingunn Midttun Godal.
Da skrantesjuke ble oppdaget i Norge i 2016, var det det første dokumenterte tilfellet av sykdommen hos hjortedyr i Europa. Siden den gang har det blitt bygget opp mye kunnskap og kompetanse om sykdommen i Norge. Denne kompetansen og kunnskapen er svært viktig for den videre håndteringen av sykdommen.
Fakta om skrantesjuke
Det er avdekket minst to typer skrantesjuke-prioner i Norge. Hos villrein har sjukdommen opptrådt smittsomt (klassisk skrantesjuke) i motsetning til syv tilfeller hos elg og én hjort hvor den trolig har oppstått spontant hos eldre dyr (atypisk skrantesjuke). Denne varianten anses som ikke smittsom mellom dyr. Skrantesjuke er en dødelig prionsykdom for hjortedyr, men er aldri påvist hos mennesker.
Symptomer på skrantesjuke er avmagring, hyppig urinering og unormal oppførsel, f.eks. dyr som ikke skyr mennesker.
Les mer om skrantesjuke på Hjorteviltportalen.
Les mer hos Veterinærinstituttet.
Kontakter Mediehenvendelser: Mattilsynets pressevakt (kl. 08.00 - 22.00, ikke SMS. Etter arbeidstid og i helger besvares i utgangspunktet kun hastesaker.) 469 12 910 pressevakt@mattilsynet.no
Subject: Texas CWD TSE Prion 3 More Documented, 185 Cases To Date
Sent: Thu, Jul 9, 2020 10:00 am
Subject: Texas CWD TSE Prion Jumps BY 13 To 182 Confirmed Cases To Date
i think some hunters that don't read this carefully are going to think this is a cure all for cwd tse contamination. IT'S NOT!
first off, it would take a strong bleach type sodium hypochlorite, that is NOT your moms bleach she uses in her clothes, and store bought stuff.
Concentrated bleach is an 8.25 percent solution of sodium hypochlorite, up from the “regular bleach” concentration of 5.25 percent.Nov 1, 2013 https://waterandhealth.org/disinfect/high-strength-bleach-2/
second off, the study states plainly;
''We found that a five-minute treatment with a 40% dilution of household bleach was effective at inactivating CWD seeding activity from stainless-steel wires and CWD-infected brain homogenates. However, bleach was not able to inactivate CWD seeding activity from solid tissues in our studies.''
''We initially tested brains from two CWD-infected mice and one uninfected mouse using 40% bleach for 5 minutes. The results from these experiments showed almost no elimination of prion seeding activity (Table 4). We then increased the treatment time to 30 minutes and tested 40% and 100% bleach treatments. Again, the results were disappointing and showed less than a 10-fold decrease in CWD-seeding activity (Table 4). Clearly, bleach is not able to inactivate prions effectively from small brain pieces under the conditions tested here.''
''We found that both the concentration of bleach and the time of treatment are critical for inactivation of CWD prions. A 40% bleach treatment for 5 minutes successfully eliminated detectable prion seeding activity from both CWD-positive brain homogenate and stainless-steel wires bound with CWD. However, even small solid pieces of CWD-infected brain were not successfully decontaminated with the use of bleach.''
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223659
https://chronic-wasting-disease.blogspot.com/2019/10/inactivation-of-chronic-wasting-disease.html
i think with all the fear from recent studies, and there are many, of potential, or likelihood of zoonosis, if it has not already happened as scjd, i think this study came out to help out on some of that fear, that maybe something will help, but the study plainly states it's for sure not a cure all for exposure and contamination of the cwd tse prion on surface materials. imo...terry
172. Establishment of PrPCWD extraction and detection methods in the farm soil
186. Serial detection of hematogenous prions in CWD-infected deer
Our ongoing studies will show whether the transmission of CWD into macaques and passage in transgenic mice represents a form of non-adaptive prion amplification, and whether macaque-adapted prions have the potential to infect mice expressing human PrP.
states.
https://www.nature.com/articles/srep11573
Prion diseases (PD) are the unique neurodegenerative proteinopathies reputed to be transmissible under field conditions since decades. The transmission of Bovine Spongiform Encephalopathy (BSE) to humans evidenced that an animal PD might be zoonotic under appropriate conditions. Contrarily, in the absence of obvious (epidemiological or experimental) elements supporting a transmission or genetic predispositions, PD, like the other proteinopathies, are reputed to occur spontaneously (atpical animal prion strains, sporadic CJD summing 80% of human prion cases).
Non-human primate models provided the first evidences supporting the transmissibiity of human prion strains and the zoonotic potential of BSE. Among them, cynomolgus macaques brought major information for BSE risk assessment for human health (Chen, 2014), according to their phylogenetic proximity to humans and extended lifetime. We used this model to assess the zoonotic potential of other animal PD from bovine, ovine and cervid origins even after very long silent incubation periods.
*** We recently observed the direct transmission of a natural classical scrapie isolate to macaque after a 10-year silent incubation period,
***with features similar to some reported for human cases of sporadic CJD, albeit requiring fourfold long incubation than BSE. Scrapie, as recently evoked in humanized mice (Cassard, 2014),
***is the third potentially zoonotic PD (with BSE and L-type BSE),
***thus questioning the origin of human sporadic cases.
We will present an updated panorama of our different transmission studies and discuss the implications of such extended incubation periods on risk assessment of animal PD for human health.
===============
***thus questioning the origin of human sporadic cases***
===============
***our findings suggest that possible transmission risk of H-type BSE to sheep and human. Bioassay will be required to determine whether the PMCA products are infectious to these animals.
==============
https://prion2015.files.wordpress.com/2015/05/prion2015abstracts.pdf
***Transmission data also revealed that several scrapie prions propagate in HuPrP-Tg mice with efficiency comparable to that of cattle BSE. While the efficiency of transmission at primary passage was low, subsequent passages resulted in a highly virulent prion disease in both Met129 and Val129 mice.
***Transmission of the different scrapie isolates in these mice leads to the emergence of prion strain phenotypes that showed similar characteristics to those displayed by MM1 or VV2 sCJD prion.
***These results demonstrate that scrapie prions have a zoonotic potential and raise new questions about the possible link between animal and human prions.
http://www.tandfonline.com/doi/abs/10.1080/19336896.2016.1163048?journalCode=kprn20
PRION 2016 TOKYO
Saturday, April 23, 2016
SCRAPIE WS-01: Prion diseases in animals and zoonotic potential 2016
Prion. 10:S15-S21. 2016 ISSN: 1933-6896 printl 1933-690X online
Taylor & Francis
Prion 2016 Animal Prion Disease Workshop Abstracts
WS-01: Prion diseases in animals and zoonotic potential
Transmission of the different scrapie isolates in these mice leads to the emergence of prion strain phenotypes that showed similar characteristics to those displayed by MM1 or VV2 sCJD prion.
These results demonstrate that scrapie prions have a zoonotic potential and raise new questions about the possible link between animal and human prions.
http://www.tandfonline.com/doi/abs/10.1080/19336896.2016.1163048?journalCode=kprn20
Title: Transmission of scrapie prions to primate after an extended silent incubation period)
*** In complement to the recent demonstration that humanized mice are susceptible to scrapie, we report here the first observation of direct transmission of a natural classical scrapie isolate to a macaque after a 10-year incubation period. Neuropathologic examination revealed all of the features of a prion disease: spongiform change, neuronal loss, and accumulation of PrPres throughout the CNS.
*** This observation strengthens the questioning of the harmlessness of scrapie to humans, at a time when protective measures for human and animal health are being dismantled and reduced as c-BSE is considered controlled and being eradicated.
*** Our results underscore the importance of precautionary and protective measures and the necessity for long-term experimental transmission studies to assess the zoonotic potential of other animal prion strains.
http://www.ars.usda.gov/research/publications/publications.htm?SEQ_NO_115=313160
From: Terry Singeltary <flounder9@verizon.net>
To: randy.weber@mail.house.gov <randy.weber@mail.house.gov>
Cc: help@cjdfoundation.org <help@cjdfoundation.org>; Debbie@CJDFoundation.org <Debbie@CJDFoundation.org>; leslie@cjdfoundation.org <leslie@cjdfoundation.org>; bsa35@case.edu <bsa35@case.edu>
Sent: Sat, Aug 29, 2020 12:37 pm
Subject: NPDPSC Transmissible Spongiform Encephalopathy TSE Prion Surveillance Funding?
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