Wednesday, November 14, 2012

PENNSYLVANIA 2012 THE GREAT ESCAPE OF CWD INVESTIGATION MOVES INTO LOUISIANA and INDIANA

PENNSYLVANIA 2012 THE GREAT ESCAPE OF CWD INVESTIGATION MOVES INTO LOUISIANA AND INDIANA
 
Got a private email.
 
 
snip...as follows ;
 
 
I would pass along a story. Nothing official has come out, but I have inside sources with multiple federal and state agencies in LA. But a deer or multiple deer, not sure which, from a CWD positive pen in PA was moved to a pen somewhere around Lake Charles, LA. The deer may have been moved to at least one other pen in LA, and possible one in MS as well, but no one really knows. There are supposedly 150 deer at the pen in Lake Charles that were quarentined and killed and they are now trying to figure out how and where to dispose of the carcasses. Everything is very sketchy and grey right now, but it is now possible that CWD could have spread to 1 or 2 more states. We shall see in the next few weeks if any kind of official press release comes out...end
 
 
 
 
 
 
so, I gave the Pa dept of ag a call. this is the kind reply I got. ...tss
 
 
From: xxxxxxxxx xxxxxx
 
 
Sent: Wednesday, November 14, 2012 4:03 PM
 
 
To: 'Flounder9@verizon.net'
 
 
Subject: Deer information
 
 
Terry - The animal moved on a certificate of veterinary inspection prior to the discovery of the positive CWD herd in Pennsylvania. Louisiana animal health authorities are investigating the movement of this deer that was epidemiologically linked to the index Pennsylvania herd, into their state. We are awaiting their response.
 
 
Since the announcement of CWD positives in Pennsylvania there are no states permitting the movement of imported Pennsylvania deer and the Department of Agriculture is not permitting the movement of any deer into the commonwealth.
 
-xxxxxx
 
 
snip...
 
 
 
Pennsylvania Department of Agriculture | Press Office 2301 North Cameron Street | Hbg PA 17110 Phone: 717.787.5085 | Fax: 717.787.1039 www.agriculture.state.pa.us
 
 
====================
 
 
I thank the Dept of Penn Ag for that kind reply and information.
 
 
 
I pray that CWD has not been transported to Louisiana from Pennsylvania, via the great escape of CWD 2012 into Pennsylvania from captive game farming. ...tss
 
 
Tuesday, November 13, 2012
 
 
PENNSYLVANIA 2012 THE GREAT ESCAPE OF CWD
 
 
 


P.S. UPDATE NOVEMBER 17, 2012 SATURDAY




AFTER posting this, i got an email, from the Son of the Father that owns said game farm in Louisiana that is now under quarantine. sadly, the day before the farm was quarantined, his Father fell out of a tree and was killed in a hunting accident. my condolences goes out to the family at this difficult time. but this nightmare just keeps getting worse. here is what the Son told me, i cannot confirm any of the following, other than the Son told me this over the phone. Louisiana refuses to comment publically about this mess $$$ ;





spoke with Donald Hodge Jr. today on his Dads farm. his Dad just passed recently (see below).


 
 
 

it seems that several deer from Pennsylvania CWD exposed herd, or cohorts, were brought to Louisiana via Donald Hodge Sr. 6 deer were transported from PA to LA by Mr. Elmer Fisher, and the truck driver was Dustin Miller. here is where the story gets a bit tricky. seems there are NO records of the deer actually ever arriving at Donald Hodge Sr.’s Farm. seems that they were suppose to go to Lafayette Louisiana, but, seems he had a silent partner, a Jarrod somebody? the son was not sure. the son said that from his fathers notes (that’s all they had to go by), these 6 deer from PA never reached his farm, even though his Dad signed for them. the 6 deer were never logged into inventory, there were no tags, no micro chips from them found. the Dept. of Ag took soil samples. to date, the son said everything at his Dad’s farm is negative. now here is where the story gets even more fishy. the location changed from Lafayette Louisiana , to a location of an unregistered hunting club, or shooting pen, as he called it, and there was some attempted deal between the silent partner, and the delivery driver, to bring the 6 deer to this shooting pen in the area of Slidell Louisiana instead. the driver was offered $1,000. to take the deer there. but he refused, so evidently, the silent partner set up a meeting place, where another trailer was brought in, and the deer were then boxed up, and sent to this shooting pen up around Slidell Louisiana, somewhere along the Mississippi border. that is where the trail runs cold for these 6 deer from PA. the Donald Hodge Farm in LA, has about 160 cervids. NONE have been slaughtered or tested to date, and are being fed, and they are under quarantine. seems in Louisiana, there are no requirements for IN STATE movement of cervids, from what Jr. told me. Donald Jr. told me the Dept. of Ag says there are two options if these 6 deer are not located.



 

1. kill the whole herd


 

2. Quarantine for 5 years.



Donald Jr. told me he could not afford to quarantine for 5 years.

 

seems right now, everything is in a holding pattern by the Dept of Ag, until they can locate the 6 deer from PA.



the Son told me that he was told there is NO indemnity program if they slaughter the deer.


 

It’s really a sad situation. Donald Hodge Sr., died Oct. 16 in a hunting accident, and Oct. 17 his farm was quarantined, and the family is beside themselves to say the least, as you can understand.




===========




UPDATE LOUISIANA NOVEMBER 20, 2012



i have been trying to find out about the Louisiana investigation into the PA deer, where they are at, and how many. from the letter below from the Dept. of ag in Pa, there is an investigation into this ongoing in PA, but they will not speak about the Louisiana deer, the Louisiana dept of ag, are the ones that can only speak about that part of this issue. so, i called them, finally got ahold of a Mr. walter, i had been trying all day to speak with Dr. Brent Robins, but when i called back at the time i was suppose to call back and speak with Dr. Robins, he had apparently left the office, after I was told to call him back at at a specific time. so i had to talk with a Mr. Walter, or a Mr. Walters or a Walter somebody, that was chief of something there at Animal Health & Food Safety in Baton Rouge, LA - (225) 925-3962 Office Telephone No: (225) 925-3962. bottom line, the investigation is ‘ongoing’, and it’s an ‘open’ investigation, and they refuse to talk anymore about it. told me they would release a report when and if the investigation is over with. so, apparently, we still have from 1 to 6 deer loose in Louisiana from PA CWD positive index herd, and nobody from Louisiana is talking about it. all PA dept of ag says is Louisiana has them, but they can’t talk about them, and all Louisiana dept. of ag will say, is it’s an open ongoing investigation. he would not even confirm, or not, if they have located said deer or how many were in the investigation. from what I got from the Son (see below), they have no clue where they are. so, we will see if any report is made in the future, or not. ...





==============================





more on Great Escape of CWD from Pennsylvania 2012 coming out of Indiana




A farm in Pennsylvania, where chronic wasting disease was detected, has sold 10 animals to farms in Indiana over the past three years. DNR spokesman Phil Bloom said two were sold to farms in Noble and Whitley counties; the rest went to two facilities in Jackson County, one of which is the site of the escape.









snip...





DNR officials are concerned because a Pennsylvania farm -- where chronic wasting disease was detected -- sold 10 animals to farms in Indiana over the past three years. Bloom said two does were sold to farms in Noble and Whitley counties; the rest went to a farm in Jackson County.


Some of the Jackson County deer were moved to a fourth facility in Jackson County, where the escape happened.


Shawn Hanley, president of the Indiana Deer and Elk Farmers' Association, said a storm caused a tree to fall on the farm's fence. A Pennsylvania buck remains on the loose.


"We have been in contact with the DNR and with the (Indiana Board of Animal Health), and will cooperate fully with attempts to recover the lost animal," Hanley said in an email.


Citing the ongoing investigation, Bloom declined to release the name of the farms. So did Douglas Metcalf, chief of staff for the Board of Animal Health.





 

Tuesday, October 23, 2012



PA Captive deer from CWD-positive farm roaming free





 


> Ag is one of the agencies cooperating in the response plan because it has responsibility for regulating captive deer and deer farms, of which there are estimated to be more 23,000 on 1,100 Pennsylvania properties.





Tuesday, November 06, 2012

PA Department of Agriculture investigating possible 2nd case of chronic wasting disease

http://chronic-wasting-disease.blogspot.com/2012/11/pa-department-of-agriculture.html





Thursday, November 01, 2012

PA GAME COMMISSION TO HOLD PUBLIC MEETING TO DISCUSS CWD Release #128-12

http://chronic-wasting-disease.blogspot.com/2012/11/pa-game-commission-to-hold-public.html





Friday, October 26, 2012

CHRONIC WASTING DISEASE CWD PENNSYLVANIA GAME FARMS, URINE ATTRACTANT PRODUCTS, BAITING, AND MINERAL LICKS

http://chronic-wasting-disease.blogspot.com/2012/10/chronic-wasting-disease-cwd.html





Tuesday, October 23, 2012

PA Captive deer from CWD-positive farm roaming free

http://chronic-wasting-disease.blogspot.com/2012/10/pa-captive-deer-from-cwd-positive-farm.html





Monday, October 15, 2012

PENNSYLVANIA GAME COMMISSION AND AGRICULTURE DEPARTMENT TO HOLD PUBLIC MEETING TO DISCUSS CWD MONITORING EFFORTS FOR IMMEDIATE RELEASE: October 15, 2012 Release #124-12

http://chronic-wasting-disease.blogspot.com/2012/10/pennsylvania-game-commission-and.html






Commissioner Strain Sir, I believe you can see the history here, where the state of Pennsylvania DNR forum banned me for speaking about CWD back in 2005 ;


Thursday, October 11, 2012

Pennsylvania Confirms First Case CWD Adams County Captive Deer Tests Positive

http://chronic-wasting-disease.blogspot.com/2012/10/pennsylvania-confirms-first-case-cwd.html






Pennsylvania CWD number of deer exposed and farms there from much greater than first thought

Published: Wednesday, October 17, 2012, 10:44 PM Updated: Wednesday, October 17, 2012, 11:33 PM

http://chronic-wasting-disease.blogspot.com/2012/10/pennsylvania-cwd-number-of-deer-exposed.html






USDA-APHIS-VS Chronic Wasting Disease National Program

Patrice N. Klein of USDA APHIS VS – National Center for Animal Health Programs provided an update on the agency’s CWD–related activities:

CWD Rule Update: The amended final rule on chronic wasting disease (CWD) is currently in departmental clearance. The rule will set minimum standards for interstate movement and establish the national voluntary Herd Certification Program (HCP). Farmed/captive cervid surveillance testing: Through FY2010, VS conducted surveillance testing on approximately 20,000 farmed /captive cervids by the immunohistochemistry (IHC) standard protocol. As of September 15, 2011, approximately 19,000 farmed /captive cervids were tested by IHC for CWD with funding to cover lab costs provided through NVSL.

Farmed/captive cervid CWD status: The CWD positive captive white-tailed deer (WTD) herd reported in Missouri (February 2010) was indemnified and depopulation activities were completed in June 2011. All depopulated animals were tested for CWD and no additional CWD positive animals were found.

In FY 2011, CWD was reported in two captive elk herds in Nebraska (December, 2010 and April 2011, respectively).

To date, 52 farmed/captive cervid herds have been identified in 11 states: CO, KS, MI, MN, MO, MT, NE, NY, OK, SD, WI.

Thirty-nine were elk herds and 13 were WTD herds. At this time, eight CWD positive herds remain – six elk herds in Colorado and the two elk herds in Nebraska.

Wild Cervid surveillance: In FY 2009 funding supported surveillance in approximately 74,330 wild cervids in 47 cooperating States. Wild cervid CWD surveillance totals are pending for fiscal year 2010 (2010 – 2011 calendar year) due to seasonal surveillance activities and completion of final cooperative agreement reporting to APHIS.

In fiscal year 2011, there are 15 ‘tier 1’ States, 20 ‘tier 2’ States, and 15 ‘tier 3’ States. Two new ‘tier 1’ States, Minnesota and Maryland, were added in fiscal year 2011 based on the new CWD detections in a free-ranging white-tailed deer in southeastern Minnesota and in western Maryland. Consequently, Delaware was upgraded to ‘tier 2’ status as an adjacent State to Maryland. For FY 2011, 45 States and 32 Tribes will receive cooperative agreement funds to complete wild cervid surveillance and other approved work plan activities. Based on FY 2012 projected budget reductions, future cooperative agreement funds will be eliminated.

APHIS CWD Funding: In FY2011, APHIS received approximately $15.8 million in appropriated funding for the CWD Program. The President’s FY 2012 budget proposes to reduce program funding for CWD by $13.9 million, leaving the program with a request of $1.925 million to provide some level of Federal coordination for the national herd certification program (HCP).

Consequently, APHIS is planning to amend its role in the program to one of Federal coordination. Based on the projected FY 2012 budget, funding for CWD cooperative agreements and indemnity funding for States and Tribes will be eliminated. Under this scenario, the States or cervid industry producers will likely be responsible for the costs of surveillance testing and indemnity for appraisal, depopulation, and disposal of CWD-positive animals.

Commodity Health Line Structure: In the FY 2012 budget, livestock commodities regulated by USDA have been organized into ‘Commodity Health Line’ structures or groupings. APHIS’ Equine, Cervid and Small Ruminant (ECSR) Health line supports efforts to protect the health and thereby improve the quality and productivity of the equine, cervid and small ruminant industries. Activities supported by the ECSR Health line range from monitoring and surveillance to investigation and response actions undertaken when health issues relevant to the industry are identified. APHIS also maintains regulations and program standards which guide ECSR activities at both the Federal and State/Tribal level.

The ECSR Health line funds essential activities necessary to maintain current ECSR surveillance and program operations while providing the flexibility to respond to new and emerging industry-specific health concerns. APHIS’ current activities include Scrapie, Chronic Wasting Disease (CWD), Slaughter Horse Transport, and Brucellosis/Tuberculosis in cervids. Overall, APHIS will use funding from the ECSR Health Line Item to support Agency efforts in the following mission areas: prevention, preparedness and communication; monitoring, surveillance and detection; response and containment; and continuity of business, mitigation and recovery

Scrapie in Deer: Comparisons and Contrasts to Chronic Wasting Disease (CWD)

Justin J. Greenlee of the Virus and Prion Diseases Research Unit, National Animal Disease Center, ARS, USDA, Ames, IA provided a presentation on scrapie and CWD in inoculated deer. Interspecies transmission studies afford the opportunity to better understand the potential host range and origins of prion diseases. We inoculated white-tailed deer intracranially (IC) and by a natural route of exposure (concurrent oral and intranasal inoculation) with a US scrapie isolate. All deer inoculated by the intracranial route had evidence of PrPSc accumulation and those necropsied after 20 months post-inoculation (PI) (3/5) had clinical signs, spongiform encephalopathy, and widespread distribution of PrPSc in neural and lymphoid tissues. A single deer that was necropsied at 15.6 months PI did not have clinical signs, but had widespread distribution of PrPSc. This highlights the facts that 1) prior to the onset of clinical signs PrPSc is widely distributed in the CNS and lymphoid tissues and 2) currently used diagnostic methods are sufficient to detect PrPSc prior to the onset of clinical signs. The results of this study suggest that there are many similarities in the manifestation of CWD and scrapie in white-tailed deer after IC inoculation including early and widespread presence of PrPSc in lymphoid tissues, clinical signs of depression and weight loss progressing to wasting, and an incubation time of 21-23 months. Moreover, western blots (WB) done on brain material from the obex region have a molecular profile consistent with CWD and distinct from tissues of the cerebrum or the scrapie inoculum. However, results of microscopic and IHC examination indicate that there are differences between the lesions expected in CWD and those that occur in deer with scrapie: amyloid plaques were not noted in any sections of brain examined from these deer and the pattern of immunoreactivity by IHC was diffuse rather than plaque-like. After a natural route of exposure, 100% of white-tailed deer were susceptible to scrapie. Deer developed clinical signs of wasting and mental depression and were necropsied from 28 to 33 months PI. Tissues from these deer were positive for scrapie by IHC and WB. Tissues with PrPSc immunoreactivity included brain, tonsil, retropharyngeal and mesenteric lymph nodes, hemal node, Peyer’s patches, and spleen. While two WB patterns have been detected in brain regions of deer inoculated by the natural route, unlike the IC inoculated deer, the pattern similar to the scrapie inoculum predominates.

Committee Business:

The Committee discussed and approved three resolutions regarding CWD. They can be found in the report of the Reswolutions Committee. Essentially the resolutions urged USDA-APHIS-VS to:

Continue to provide funding for CWD testing of captive cervids

Finalize and publish the national CWD rule for Herd Certification and Interstate Movement

Evaluate live animal test, including rectal mucosal biopsy, for CWD in cervids


http://www.usaha.org/Portals/6/Reports/2011/report-cwal-2011.pdf





how many states have $465,000., and can quarantine and purchase there from, each cwd said infected farm, but how many states can afford this for all the cwd infected cervid game ranch type farms ???


? game farms in a state X $465,000., do all these game farms have insurance to pay for this risk of infected the wild cervid herds, in each state ???





Tuesday, December 20, 2011


CHRONIC WASTING DISEASE CWD WISCONSIN Almond Deer (Buckhorn Flats) Farm Update DECEMBER 2011


The CWD infection rate was nearly 80%, the highest ever in a North American captive herd.


RECOMMENDATION: That the Board approve the purchase of 80 acres of land for $465,000 for the Statewide Wildlife Habitat Program in Portage County and approve the restrictions on public use of the site.


Form 1100-001


(R 2/11)


NATURAL RESOURCES BOARD AGENDA ITEM


SUBJECT: Information Item: Almond Deer Farm Update


FOR: DECEMBER 2011 BOARD MEETING


TUESDAY


TO BE PRESENTED BY TITLE: Tami Ryan, Wildlife Health Section Chief


SUMMARY:



http://dnr.wi.gov/about/nrb/2011/december/12-11-2b2.pdf



http://chronic-wasting-disease.blogspot.com/2011/12/chronic-wasting-disease-cwd-wisconsin.html





*** Spraker suggested an interesting explanation for the occurrence of CWD. The deer pens at the Foot Hills Campus were built some 30-40 years ago by a Dr. Bob Davis. At or abut that time, allegedly, some scrapie work was conducted at this site. When deer were introduced to the pens they occupied ground that had previously been occupied by sheep.



http://collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf





2011



*** After a natural route of exposure, 100% of white-tailed deer were susceptible to scrapie.



http://www.usaha.org/Portals/6/Reports/2011/report-cwal-2011.pdf






Generation of a new form of human PrPSc in vitro by inter-species transmission from cervids prions


Marcelo A. Barria1, Glenn C. Telling2, Pierluigi Gambetti3, James A. Mastrianni4 and Claudio Soto1,* 1Mitchell Center for Alzheimer’s disease and related Brain disorders, Dept of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA 2Dept of Microbiology, Immunology & Molecular Genetics, and Neurology, Sanders Brown Center on Aging, University of Kentucky Medical Center, Lexington, KY, USA 3Institute of Pathology, Case Western Reserve University, Cleveland, OH, USA 4Dept of Neurology, University of Chicago, Chicago, IL, USA. Running Title: Conversion of human PrPC by cervid PrPSc Keywords: Prion / transmissible spongiform encephalopathy / infectivity / misfolded prion protein / prion strains * To whom correspondence should be addressed. University of Texas Houston Medical School, 6431 Fannin St, Houston, TX 77030. Tel 713-5007086; Fax 713-5000667; E-mail Claudio.Soto@uth.tmc.edu The latest version is at http://www.jbc.org/cgi/doi/10.1074/jbc.M110.198465 JBC Papers in Press.




Published on January 4, 2011 as Manuscript M110.198465 Copyright 2011 by The American Society for Biochemistry and Molecular Biology, Inc. 5, Downloaded from www.jbc.org by guest, on November 11, 2012 2




Prion diseases are infectious neurodegenerative disorders affecting humans and animals that result from the conversion of normal prion protein (PrPC) into the misfolded prion protein (PrPSc). Chronic wasting disease (CWD) is a prion disorder of increasing prevalence within the United States that affects a large population of wild and captive deer and elk. Determining the risk of transmission of CWD to humans is of utmost importance, considering that people can be infected by animal prions, resulting in new fatal diseases. To study the possibility that human PrPC can be converted into the misfolded form by CWD PrPSc we performed experiments using the Protein Misfolding Cyclic Amplification (PMCA) technique, which mimic in vitro the process of prion replication. Our results show that cervid PrPSc can induce the conversion of human PrPC, but only after the CWD prion strain has been stabilized by successive passages in vitro or in vivo. Interestingly, the newly generated human PrPSc exhibits a distinct biochemical pattern that differs from any of the currently known forms of human PrPSc. Our results also have profound implications for understanding the mechanisms of prion species barrier and indicate that the transmission barrier is a dynamic process that depend on the strain and moreover the degree of adaptation of the strain. If our findings are corroborated by infectivity assays, they will imply that CWD prions have the potential to infect humans, and that this ability depends on CWD strain adaptation.




Various studies aimed to analyze the transmission of CWD to transgenic mice expressing human PrP have consistently given negative results (9-11), indicating a strong species barrier. This conclusion is consistent with our many failed experiments to attempt converting human PrPC with natural CWD, even after pushing the PMCA conditions (see figure 1). We found successful conversion only after adaptation of the CWD prion strain by successive passages in vitro or in cervid transgenic mice. We are not aware that in any of the transgenic mice studies the inoculum used was a previously stabilized CWD strain. Although, it has been shown that strain stabilization in vitro by PMCA (17;26) and in vivo using experimental rodents (36) has similarities with the strain adaptation process occurring in natural hosts, we cannot rule out that the type of CWD strain adaptation that is required to produce strains transmissible to humans may take much longer time in cervids or not occur at all. An important experiment will be to study transmissibility to humanized transgenic mice of CWD passed experimentally in deer several times. Besides the importance of our results for public health in relation to the putative transmissibility of CWD to humans, our data also illustrate a very important and novel scientific concept related to the mechanism of prion transmission across species barriers. Today the view is that species barrier is mostly controlled by the degree of similarity on the sequence of the prion protein between the host and the infectious material (4). In our study we show that the strain and moreover the stabilization of the strain plays a major role in the inter-species transmission. In our system there is no change on the protein sequence, but yet strain adaptation results in a complete change on prion transmissibility with potentially dramatic consequences. Therefore, our findings lead to a new view of the species barrier that should not be seen as a static process, but rather a dynamic biological phenomenon that can change over time when prion strains mature and evolve. It remains to be investigated if other species barriers also change upon progressive strain adaptation of other prion forms (e.g. the sheep/human barrier).




Our results have far-reaching implications for human health, since they indicate that cervid PrPSc can trigger the conversion of human PrPC into PrPSc, suggesting that CWD might be infectious to humans. Interestingly our findings suggest that unstable strains from CWD affected animals might not be a problem for humans, but upon strain stabilization by successive passages in the wild, this disease might become progressively more transmissible to man.




 http://www.jbc.org/content/early/2011/01/04/jbc.M110.198465.full.pdf







Generation of a New Form of Human PrPScin Vitro by Interspecies Transmission from Cervid Prions*




Marcelo A. Barria‡, Glenn C. Telling§, Pierluigi Gambetti¶, James A. Mastrianni‖ and Claudio Soto‡,1 + Author Affiliations




From the ‡Mitchell Center for Alzheimer's Disease and Related Brain Disorders, Department of Neurology, University of Texas Medical School at Houston, Houston, Texas 77030, the §Departments of Microbiology, Immunology, and Molecular Genetics and Neurology, Sanders Brown Center on Aging, University of Kentucky Medical Center, Lexington, Kentucky 40506, the ¶Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, and the ‖Department of Neurology, The University of Chicago, Chicago, Illinois 60637 1 To whom correspondence should be addressed: University of Texas Medical School at Houston, 6431 Fannin St., Houston, TX 77030. Tel.: 713-500-7086; Fax: 713-500-0667; E-mail: claudio.soto@uth.tmc.edu.




Abstract




Prion diseases are infectious neurodegenerative disorders that affect humans and animals and that result from the conversion of normal prion protein (PrPC) into the misfolded prion protein (PrPSc). Chronic wasting disease (CWD) is a prion disorder of increasing prevalence within the United States that affects a large population of wild and captive deer and elk. Determining the risk of transmission of CWD to humans is of utmost importance, considering that people can be infected by animal prions, resulting in new fatal diseases. To study the possibility that human PrPC can be converted into the misfolded form by CWD PrPSc, we performed experiments using the protein misfolding cyclic amplification technique, which mimics in vitro the process of prion replication. Our results show that cervid PrPSc can induce the conversion of human PrPC but only after the CWD prion strain has been stabilized by successive passages in vitro or in vivo. Interestingly, the newly generated human PrPSc exhibits a distinct biochemical pattern that differs from that of any of the currently known forms of human PrPSc. Our results also have profound implications for understanding the mechanisms of the prion species barrier and indicate that the transmission barrier is a dynamic process that depends on the strain and moreover the degree of adaptation of the strain. If our findings are corroborated by infectivity assays, they will imply that CWD prions have the potential to infect humans and that this ability progressively increases with CWD spreading.





http://www.jbc.org/content/286/9/7490






http://www.jbc.org/content/286/9/7490.full.pdf+html






UPDATED DATA ON 2ND CWD STRAIN



Wednesday, September 08, 2010 CWD PRION CONGRESS SEPTEMBER 8-11 2010



http://chronic-wasting-disease.blogspot.com/2010/09/cwd-prion-2010.html








Tuesday, June 05, 2012


Captive Deer Breeding Legislation Overwhelmingly Defeated During 2012 Legislative Session


http://chronic-wasting-disease.blogspot.com/2012/06/captive-deer-breeding-legislation.html







Friday, August 31, 2012


COMMITTEE ON CAPTIVE WILDLIFE AND ALTERNATIVE LIVESTOCK and CWD 2009-2012 a review


http://chronic-wasting-disease.blogspot.com/2012/08/committee-on-captive-wildlife-and.html







Friday, August 24, 2012


Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America



The overall diagnostic specificity was 99.8%. Selective use of antemortem rectal biopsy sample testing would provide valuable information during disease investigations of CWD-suspect deer herds.




http://chronic-wasting-disease.blogspot.com/2012/08/diagnostic-accuracy-of-rectal-mucosa.html


 
 

 
TSS

posted by Terry S. Singeltary Sr. at 6:00 PM

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