Saturday, January 19, 2008

THREE DECATUR COUNTY DEER CONFIRMED POSITIVE FOR CHRONIC WASTING DISEASE KANSAS

Saturday, January 19, 2008 THREE DECATUR COUNTY DEER CONFIRMED POSITIVE FOR CHRONIC WASTING DISEASE KANSAS

THREE DECATUR COUNTY DEER CONFIRMED POSITIVE FOR CHRONIC WASTING DISEASE

CWD contingency plan includes further sampling

PRATT--Three white-tailed deer taken by hunters in Decatur County have tested positive for chronic wasting disease (CWD), according to the Kansas Department of Wildlife and Parks.

Dr. Ruby Mosher, KDWP’s wildlife disease coordinator, said the initial screening tests performed by Kansas State Veterinary Diagnostic Laboratory have been confirmed by the National Veterinary Services Laboratory in Ames, Iowa. All three deer were taken by hunters along Sappa Creek in central Decatur County, north of Oberlin, which is in the northwest corner of the state. Testing is still to be completed on approximately two-thirds of the samples collected by KDWP for testing. The samples from northwestern Kansas are given priority since they are from deer that have a higher known risk of being exposed to CWD than those in the rest of the state. As results are returned over the next 6 to 8 weeks, regular updates will be posted on the KDWP website here.

CWD has been detected twice previously in Kansas. The first case was in 2001 in a captive elk herd in Harper County. The other occurred during the 2005 hunting season in a wild whitetail doe harvested in Cheyenne County.

Last month, the Nebraska Game and Parks Commission reported a CWD-positive deer from an area just a few miles north of Decatur County, in Red Willow County, Nebraska.

Wildlife biologists from Kansas and Nebraska plan to sample more deer in the vicinity in February to help determine the prevalence of the disease in the area.

Tissue samples from more than 2,200 deer taken by hunters during the most recent Kansas hunting season have been submitted for lab analysis. The three affected deer from Decatur County were among those samples, and the hunters who shot those deer have been notified.

KDWP biologists have conducted annual sampling of hunter-harvested and road-killed deer since 1996. Although research is underway, there is currently no vaccine or other biological method of preventing CWD. The only tool is to prevent the spread of CWD to new areas, because once the infective particle (an abnormal prion) is deposited into the environment -- either through an infected carcass or from a live animal -- it may exist for a decade or more, capable of infecting a healthy deer. Despite the recent occurrences, the likelihood of finding CWD in a wild deer harvested in Kansas is small. That small likelihood decreases even more the farther from northwestern Kansas the deer lived. In recent years, numerous cases of CWD have been documented in neighboring areas of Colorado, Nebraska and Wyoming.

While CWD is fatal to infected deer and elk, humans have never been known to contract the disease. CWD is a member of the group of diseases called transmissible spongiform encephalopathies (TSEs). Other diseases in this group include scrapie in sheep and goats, bovine spongiform encephalopathy (BSE or mad cow disease) in cattle, and Cruetzfeldt-Jacob disease in people. CWD is a progressive, fatal disease that results in small holes developing in the brain, giving it a sponge-like appearance under the microscope. Decreased brain function causes the animal to display neurological symptoms such as depression, droopy head, staggering, loss of appetite, and a lack of response to man. The continuing deterioration of the brain leads to other symptoms such as weight loss, drooling, and excessive thirst. Caution is advised because of unknown factors associated with prion diseases, but no human health risks have been discovered where CWD occurs.

The symptoms of CWD include loss of body weight, stumbling, holding the head at an odd angle, circling, non-responsiveness to people, and pneumonia. Any sick deer or elk should be reported it to the nearest KDWP office or the Emporia Research Office, 620-342-0658. Hunters can help protect the health of the Kansas deer herd by taking the following steps to avoid accidentally introducing CWD to a new area in Kansa s: • do not transport deer carcasses far from the area where the deer lived, especially from areas where CWD has been detected, such as northwestern Kansas; and • if a carcass is transported, the hunter should make sure that carcass waste is not dumped into the environment where local deer or elk can come into contact with it. Carcass waste can be disposed of by double-bagging it and taking it to a landfill.

The Chronic Wasting Disease Alliance maintains an online clearinghouse of information about the disease ( www.cwd-info.org). More information is also available on the KDWP website (enter “CWD” in the search box at the KDWP website: www.kdwp.state.ks.us). Contact Bob Mathews at KDWP’s Pratt office (620/672-5911) for more information.

http://www.kdwp.state.ks.us/news/hunting/three_decatur_county_deer_confirmed_positive_for_chronic_wasting_disease

http://www.kdwp.state.ks.us/news/content/pdf/18941


3 Decatur County deer found to have fatal disease

BY MICHAEL PEARCE The Wichita Eagle

http://www.kansas.com/news/state/story/285844.html


Though similar to Creutzfeldt-Jakob disease, which reportedly killed a man from the Colby area this week, chronic wasting has yet to be passed to livestock or humans. ...

PLEASE note, this statement is in line with the same BSe that was stated about the death of a man recently from 'suspected' sporadic Creutzfeldt Jakob Disease in the Colby area. Chronic Wasting Disease in deer and elk i.e. CWD, is a TSE Transmissible Spongiform Encephalopathy, same as BSE or Bovine Spongiform Encephalopathy in cattle (oh, and sheep and goats too, yes BSE has tranasmitted to both). IT really gets confusing, but our friendly federal officials (industry reps) love to play down all this as if it never has, and never will, sadly, it already has. i urge all of you to READ THE SCIENCE AND TRANSMISSION STUDIES TO DATE. CWD has transmitted to cattle and primates, transmission studies have never been done on man.

MY comment about the recent 'suspect' case of sporadic CJD in the Colby area, and please remember this one thing about the infamous sporadic CJD's ;

there is 26790 hits on 'sporadic' at pub-med.

there is 12830 hits on 'sporadic disease' at pub-med.

with the first few being ;

Comparison Analysis of Gene Expression Patterns between Sporadic Alzheimer's and Parkinson's Disease.

http://www.ncbi.nlm.nih.gov/pubmed/18198416?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Sporadic ALS with early onset respiratory failure is not associated with IGHMBP2 gene mutations.

http://www.ncbi.nlm.nih.gov/pubmed/18187479?ordinalpos=10&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Sporadic Multiple Cerebral Cavernomatosis: Report of a Case and Review of Literature

http://www.ncbi.nlm.nih.gov/pubmed/18195658?ordinalpos=7&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

A sporadic disease is one that occurs only occasionally in a population (i.e., prevalence is zero).
http://mansfield.osu.edu/~sabedon/biol2045.htm


sporadic CJD is NOT a single strain.

sporadic CJD is simply a human TSE, which route and source is unknown. ...


Date: 2008-01-17T19:37:31

IN reply to 'a real health threat'.

I can assure you both are a real health threat. my mother died from the Heidenhain Variant of CJD 'confirmed', and i damn near died from the MRSA, after refusing blood and cadaver bone. go figure. but this case of CJD in question, it could very well have been caused by the USA strain of mad cow disease i.e. BASE, of which the last two case in the USA were. IF anyone would take the time to read the science, the USA mad cow strain i.e. BASE is more like some sub-types of sporadic CJD, NOT the UK nvCJD. Plus, in 2007 alone, 5 cases of the atypical scrapie NOR-98 were documented in 5 different states in the USA, again, this strain of scrapie i.e. the NOR-98 closely resembles that of sporadic CJD, of which is increasing here in the USA. SO, to catigorically state that this case is not related to mad cow, is not accurate. they simply don't know. could be from many TSE sources here in the USA. ...

see full text and references ;

http://pod01.prospero.com/n/pfx/forum.aspx?tsn=22&nav=display&webtag=kr-kansastm&tid=19673


P01.47

Quantifying the Species Barrier in Chronic Wasting Disease by a Novel in vitro Conversion Assay

Li, L1; Coulthart, MB2; Balachandran, A3; Chakrabartty, A4; Cashman, NR1 1University of British Columbia, Brain Research Centre, Canada; 2Public Health Agency of Canada, National Microbiology Laboratory, Canada; 3Animal Diseases Research Institute, Canada Food Inspection Agency, National Reference Laboratory for Scrapie and CWD, Canada; 4Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Canada

Background: Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy that can affect North American cervids (deer, elk, and moose). Although the risk of CWD crossing the species barrier and causing human disease is still unknown, however, definite bovine spongiform encephalopathy (BSE) transmission to humans as variant CJD (vCJD), it would seem prudent to limit the exposure of humans to CWD.

Aim: In view of the fact that BSE can be readily transmitted to non-bovid species, it is important to establish the species susceptibility range of CWD.

Methods: In vitro conversion system was performed by incubation of prions with normal brain homogenates as described before, and protease K (PK) resistant PrP was determined by immunoblotting with 6H4 monoclonal prion antibody.

Results: Our results demonstrate that PrPC from cervids (including moose) can be efficiently converted to a protease-resistant form by incubation with elk CWD prions, presumably due to sequence and structural similarities between these species. Interestingly, hamster shows a high conversion ratio by PrPCWD. Moreover, partial denaturation of substrate PrPC can apparently overcome the structural barriers between more distant species.

Conclusions: Our work correctly predicted the transmission of CWD to a wild moose. We find a species barrier for prion protein conversion between cervids and other species, however, this barrier might be overcome if the PrPC substrate has been partially denatured in a cellular environment. Such an environment might also promote CWD transmission to non-cervid species, *** including humans. Acid/GdnHCl-treated brain PrPC was a superior substrate for the in vitro conversion than PrPC treated at physiological pH. This has implications for the process by which the prion protein is converted in disease.

http://www.prion2007.com/pdf/Prion%20Book%20of%20Abstracts.pdf


Epidemiologic studies have also been initiated to identify human cases of prion disease among persons with an increased risk for exposure to potentially CWD-infected deer or elk meat (47). If such cases are identified, laboratory data showing similarities of the etiologic agent to that of the CWD agent would strengthen the conclusion for a causal link. Surveillance for human prion diseases, particularly in areas where CWD has been detected, remains important to effectively monitor the possible transmission of CWD to humans. Because of the long incubation period associated with prion diseases, convincing negative results from epidemiologic and experimental laboratory studies would likely require years of follow-up. In the meantime, to minimize the risk for exposure to the CWD agent, hunters should consult with their state wildlife agencies to identify areas where CWD occurs and continue to follow advice provided by public health and wildlife agencies. Hunters should avoid eating meat from deer and elk that look sick or test positive for CWD. They should wear gloves when field-dressing carcasses, bone-out the meat from the animal, and minimize handling of brain and spinal cord tissues. As a precaution, hunters should avoid eating deer and elk tissues known to harbor the CWD agent (e.g., brain, spinal cord, eyes, spleen, tonsils, lymph nodes) from areas where CWD has been identified.

http://www.cdc.gov/ncidod/EID/vol10no6/03-1082.htm


From: TSS (216-119-163-189.ipset45.wt.net) Subject: CWD aka MAD DEER/ELK TO HUMANS ??? Date: September 30, 2002 at 7:06 am PST

From: "Belay, Ermias" To: Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias" Sent: Monday, September 30, 2002 9:22 AM Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS

Dear Sir/Madam, In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD.

That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.

Ermias Belay, M.D. Centers for Disease Control and Prevention

-----Original Message----- From: Sent: Sunday, September 29, 2002 10:15 AM To: [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask] Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS

Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS

also,

A. Aguzzi - Chronic Wasting Disease (CWD) also needs to be addressed. Most serious because of rapid horizontal spread and higher prevalence than BSE in UK, up to 15% in some populations. Also may be a risk to humans - evidence that it is not dangerous to humans is thin.

http://www.tseandfoodsafety.org/activities/bse_conference_basel_april_02/2summary_of_conference.htm

JOURNAL OURNAL OF VIROLOGY IROLOGY, Nov. 2005, p. 13794–13796 Vol. 79, No. 21 0022-538X/05/$08.00 !0 doi:10.1128/JVI.79.21.13794–13796.2005 Copyright © 2005, American Society for Microbiology. All Rights Reserved.

NOTES

Interspecies Transmission of Chronic Wasting Disease Prions to Squirrel Monkeys (Saimiri sciureus sciureus)

http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0704&L=sanet-mg&T=0&P=1165


From: "Terry S. Singeltary Sr."Subject: CWD UPDATE 88 AUGUST 31, 2007

http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0709&L=sanet-mg&T=0&P=450


Date: Wed, 29 Aug 2007 21:13:08 -0500From: "Terry S. Singeltary Sr." Subject: CWD NEW MEXICO RECORDS IT'S 19 CASE (near Texas border again)

http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-mg&T=0&P=26079


Subject: Monitoring the Potential Transmission of Chronic Wasting Disease to Humans Using a Hunter Registry Database in Wyoming Date: August 30, 2007 at 6:46 pm PST

http://lists.ifas.ufl.edu/cgi-bin/wa.exe?A2=ind0708&L=sanet-mg&T=0&P=27654


PLEASE NOTE IN USA CJD UPDATE AS AT JUNE 2007, please note steady increasein ''TYPE UNKNOWN''. ...TSS

1 Acquired in the United Kingdom; 2 Acquired in Saudi Arabia; 3 Includes 17inconclusive and 9 pending (1 from 2006, 8from 2007); 4 Includes 17 non-vCJD type unknown (2 from 1996, 2 from 1997, 1from 2001, 1 from 2003, 4 from 2004, 3from 2005, 4 from 2006) and 36 type pending (2 from 2005, 8 from 2006,

*** 26 from 2007)

http://www.cjdsurveillance.com/pdf/case-table.pdf


http://pro-med.blogspot.com/2007/11/proahedr-prion-disease-update-2007-07.html


http://chronic-wasting-disease.blogspot.com/


Monday, January 07, 2008 CWD Update 89 January 4, 2008

http://chronic-wasting-disease.blogspot.com/2008/01/cwd-update-89-january-4-2008.html


Wednesday, December 12, 2007 SEAC 99th meeting on Friday 14th December 2007

16 January 2008 - The final minutes of the 98th SEAC meeting have been published.

PUBLIC QUESTION AND ANSWER SESSION 2

© SEAC 2007

SEAC considered a question about possible links between CJD cases and animal TSEs in the United States of America (USA).

http://www.seac.gov.uk/summaries/seac99_summary.pdf


SEAC 99th meeting on Friday 14th December 2007

http://seac992007.blogspot.com/


Friday, January 11, 2008

CJD HUMAN TSE REPORT UK, USA, CANADA, and Mexico JANUARY 2008

http://cjdmadcowbaseoct2007.blogspot.com/2008/01/cjd-human-tse-report-uk-usa-canada-and.html


Saturday, January 12, 2008

Prominent and Persistent Extraneural Infection in Human PrP Transgenic Mice Infected with Variant CJD

http://cjdmadcowbaseoct2007.blogspot.com/2008/01/prominent-and-persistent-extraneural.html


ANIMAL HEALTH REPORT 2006 (BSE h-BASE ALABAMA)

http://animalhealthreport2006.blogspot.com/


BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA, A REVIEW OF SORTS

http://madcowtesting.blogspot.com/


MADCOW USDA the untold story

http://madcowusda.blogspot.com/


BSE OIE USDA

http://madcowtesting.blogspot.com/2008/01/bse-oie-usda.html


CREUTZFELDT JAKOB DISEASE MAD COW BASE UPDATE USA

http://cjdmadcowbaseoct2007.blogspot.com/


SCRAPIE USA

http://scrapie-usa.blogspot.com/


NOR-98 ATYPICAL SCRAPIE CASES USA

http://nor-98.blogspot.com/


Transmissible Mink Encephalopathy TME

http://transmissible-mink-encephalopathy.blogspot.com/


CHRONIC WASTING DISEASE

http://chronic-wasting-disease.blogspot.com/


Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States

http://cjdusa.blogspot.com/


CJD QUESTIONNAIRE

http://cjdquestionnaire.blogspot.com/


TSEAC MEETINGS

http://tseac.blogspot.com/


I only ponder how many sporadic CJDs in the USA are type 2 PrPSc?

http://www.neurology.org/cgi/eletters/60/2/176#535


THE PATHOLOGICAL PROTEIN

Hardcover, 304 pages plus photos and illustrations. ISBN 0-387-95508-9 June 2003
BY Philip Yam

CHAPTER 14 LAYING ODDS

Answering critics like Terry Singeltary, who feels that the U.S. under-counts CJD, Schonberger conceded that the current surveillance system has errors but stated that most of the errors will be confined to the older population.

http://www.thepathologicalprotein.com/


doi:10.1016/S1473-3099(03)00715-1Copyright © 2003 Published by Elsevier Ltd.

Newsdesk

Tracking spongiform encephalopathies in North America

Xavier Bosch

Available online 29 July 2003. Volume 3, Issue 8, August 2003, Page 463

"My name is Terry S Singeltary Sr, and I live in Bacliff, Texas. I lost my mom to hvCJD (Heidenhain variant CJD) and have been searching for answers ever since. What I have found is that we have not been told the truth. CWD in deer and elk is a small portion of a much bigger problem." ...

http://www.thelancet.com/journals/laninf/article/PIIS1473309903007151/fulltext


http://download.thelancet.com/pdfs/journals/1473-3099/PIIS1473309903007151.pdf


Diagnosis and Reporting of Creutzfeldt-Jakob Disease

Singeltary, Sr et al. JAMA.2001; 285: 733-734.

http://jama.ama-assn.org/http://www.neurology.org/cgi/eletters/60/2/176#535


Like lambs to the slaughter 31 March 2001 Debora MacKenzie Magazine issue 2284

FOUR years ago, Terry Singeltary watched his mother die horribly from a degenerative brain disease. Doctors told him it was Alzheimer's, but Singeltary was suspicious. The diagnosis didn't fit her violent symptoms, and he demanded an autopsy. It showed she had died of sporadic Creutzfeldt-Jakob disease. Most doctors believe that sCJD is caused by a prion protein deforming by chance into a killer. But Singeltary thinks otherwise. He is one of a number of campaigners who say that some sCJD, like the variant CJD related to BSE, is caused by eating meat from infected animals. Their suspicions have focused on sheep carrying scrapie, a BSE-like disease that is wide spread in flocks across Europe and North America. Now scientists in France have stumbled across new evidence that adds weight to the campaigners' fears. To their complete surprise, the researchers found that one strain of scrapie causes the same brain damage in mice as sCJD. "This means we cannot rule out that at least some sCJD may be caused by some strains of scrapie," says team member Jean-Philippe Deslys of the French Atomic Energy Commission's medical research laboratory in Fontenay-aux-Roses, south-west of Paris. Hans Kretschmar of the University of Göttingen, who coordinates CJD surveillance in Germany, is so concerned by the findings that he now wants to trawl back through past sCJD cases to see if any might have been caused by eating infected mutton or lamb. ...

http://www.newscientist.com/article/mg16922840.300-like-lambs-to-the-slaughter.html


DER SPIEGEL (9/2001) - 24.02.2001 (9397 Zeichen)USA: Loch in der MauerDie BSE-Angst erreicht Amerika: Trotz strikter Auflagen gelangte in Texasverbotenes Tiermehl ins Rinderfutter - die Kontrollen der Aufsichtsbehördensind lax. Link auf diesen Artikel im Archiv: http://service.spiegel.de/digas/find?DID=18578755"

Its as full of holes as Swiss Cheese" says Terry Singeltary of the FDA regulations. ...

http://service.spiegel.de/digas/servlet/find/DID=18578755


Thu Dec 6, 2007 11:38

FDA IN CRISIS MODE, AMERICAN LIVES AT RISK

http://www.cidrap.umn.edu/cidrap/content/fs/food-disease/news/dec0407fda.html


FDA SCIENCE AND MISSION AT RISK

http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4329b_02_01_FDA%20Report%20on%20Science%20and%20Technology.pdf


2 January 2000 British Medical Journal

U.S. Scientist should be concerned with a CJD epidemic in the U.S., as well

http://www.bmj.com/cgi/eletters/320/7226/8/b#6117


15 November 1999 British Medical Journal

vCJD in the USA * BSE in U.S.

http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406


BSE (Mad Cow) Update: Do Reports of sCJD Clusters Matter?

snip... see full text ;

http://cjdtexas.blogspot.com/


Terry S. Singeltary Sr.
P.O. Box 42
Bacliff, Texas USA 77518

Monday, January 07, 2008

CWD Update 89 January 4, 2008

Monday, January 07, 2008 CWD Update 89 January 4, 2008

CWD Update 89 January 4, 2008

CWD Update 89

January 4, 2008

State and Provincial Updates

Montana:

Neil Anderson, Montana Fish, Wildlife and Parks, provides the following: As of December 11, 2007 a total of 1481 samples have been submitted for testing. Results from 177 elk, 1060 mule deer, 239 white-tailed deer and one moose have been received with no evidence of CWD being detected. Results are pending for the remaining 8 samples and surveillance efforts for symptomatic animals is ongoing. Table 1 indicates the number of samples collected within surveillance areas of eastern Montana. Hunter-harvested animals comprised the majority of animals tested (93.5%, n = 1381) followed by road-killed animals (5.5%, n = 81) and symptomatic animals (1.0%, n = 15). Montana FWP CWD information is available at:

http://fwp.mt.gov/hunting/chronicWD.html

snip...

Nebraska:

Bruce Trindle, Nebraska Game and Parks Commission, provides the following: The Nebraska Game and Parks Commission tested more than 3,200 hunter-harvested deer for chronic wasting disease (CWD) during the firearm deer season that ended November 18. A total of 44 elk were also tested during the elk season. A total of 17 deer tested positive for the disease, and all but three of the positive tests were from deer harvested within the endemic area in the Panhandle. None of the elk tested positive. The three deer that tested positive outside the panhandle were all white-tailed deer. A firearm hunter in Keith County shot one of the afflicted deer a few miles west of Ogallala on the South Platte River. The second positive deer was shot in Red Willow County on the Beaver Creek drainage near the Kansas border, and the third positive was harvested in Hall County a few miles south of Alda. Biologists plan on sampling more deer from the areas where the disease has not previously been detected. Additional samples will help indicate the prevalence of CWD within those immediate harvest locations. According to Trindle, “The prevalence of CWD in deer tested over the past three years has been less than one percent, and the distribution of the disease has expanded very slowly.”

The Nebraska Game and Parks Commission confirmed CWD in the state’s deer population in 2000. To date there have been 133 free ranging deer that tested positive for CWD through the Commission’s surveillance program which has sampled over 33,000 deer. CWD has never been detected in the Nebraska wild elk population. The Commission plans on continuing its diligent testing of Nebraska’s deer herds for this disease. Nebraska Game & Parks Commission CWD information is at:

http://www.ngpc.state.ne.us/wildlife/guides/CWD/cwd.asp

South Dakota:

Steve Griffin, South Dakota Game, Fish and Parks, provides the following: In the South Dakota CWD Surveillance period of July 1, 2007 to December 31, 2007 a total of 2,342 samples were collected for CWD surveillance. Breakdown of the sampling is as follows: 475 elk sampled--473 NOT Positive-- 1 result pending (1 Positive Elk Found) 536 mule deer sampled--518 NOT Positive-- 13 results pending (5 Positive MD Found) 1,331 white-tailed deer--1,300 NOT Positive-- 23 results pending (8 Positive WT Found) Below is a listing of the positive cervids that have been found in South Dakota during the surveillance period of July 1, 2007 to December 31, 2007. 1. White-tailed deer female from Unit BD3 in Pennington County. (Hunter Harvest) 2. Elk female from Unit H3B in Custer County. (Hunter Harvest) 3. White-tailed deer female from Unit BD3 in Pennington County. (Vehicle Kill) 4. White-tailed deer male from Rapid City in Pennington County. (Vehicle Kill) 5. White-tailed female from Unit 21A in Pennington County. (Hunter Harvest) 6. White-tailed male from Unit 27B in Fall River County. (Hunter Harvest) 7. Mule deer male from Unit 27A in Fall River County. (Hunter Harvest) 8. Mule deer female from Unit 27B in Fall River County. (Hunter Harvest) 9. White-tailed female from Unit CU1 in CSP in Custer County. (Hunter Harvest) 10. White-tailed male from Unit 27A in Fall River County. (Hunter Harvest) 11. White-tailed female from Unit 27B in Fall River County. (Hunter Harvest) 12. Mule deer male from Unit 27B in Fall River County. (Hunter Harvest) 13. Mule deer male from Unit 27A in Fall River County. (Hunter Harvest) 14. Mule deer female from Unit 27A in Fall River County. (Sick/Surveillance) In Summary: South Dakota is reporting a total of 14 positive cervids (1 elk, 13 deer) in the testing period of July 1, 2007 to December 31, 2007. To date, South Dakota has found 72 cases of CWD (52 deer and 20 elk) in free ranging deer and elk since testing began in 1997. Wind Cave National Park accounts for 17 of these animals (9 elk, 8 deer). Three elk and 1 deer have been found in Custer State Park. A total of 17,188 wild deer and elk have been tested for CWD since 1997. South Dakota Game, Fish, and Parks CWD information is at:

http://www.sdgfp.info/Wildlife/hunting/BigGame/CWD.htm


West Virginia:

The following press release (shortened for inclusion on this update) was issued by the West Virginia Department of Natural Resources on December 17, 2007: Five Additional Deer Test Positive for Chronic Wasting Disease in Hampshire County, West Virginia. Preliminary test results have detected the Chronic Wasting Disease (CWD) agent in five hunter-harvested deer collected in Hampshire County during the 2007 deer firearms hunting season. “As part of our agency’s ongoing and intensive CWD surveillance effort, samples were collected from 1,285 hunter-harvested deer brought to game checking stations in Hampshire County,” noted Frank Jezioro, Director for the West Virginia Division of Natural Resources (DNR). The five CWD positive deer included one 2.5 year-old doe, two 2.5 year-old bucks, one 3.5 year-old buck, and one 4.5 year-old buck. Four of the five deer were harvested within the Hampshire County CWD Containment Area (i.e., that portion of Hampshire County located North of U.S. Route 50). The fifth deer was also harvested in Hampshire County, but it was killed outside the CWD Containment Area near Yellow Springs, West Virginia. CWD has now been detected in a total of 19 deer in Hampshire County (i.e., one road-killed deer confirmed in 2005, four deer collected by the DNR in 2005, five deer collected by the DNR in 2006, one hunter-harvest deer taken during the 2006 deer season, three deer collected by the DNR in 2007 and five hunter-harvested deer taken during the 2007 deer season). Operating within guidelines established by its CWD – Incident Response Plan, the DNR has taken the steps necessary to implement appropriate management actions designed to control the spread of this disease, prevent further introduction of the disease, and possibly eliminate the disease from the state. Full text of the press release is at:

http://www.wvdnr.gov/2007news/07news174.shtm


West Virginia DNR CWD information is available at:

http://www.wvdnr.gov

(search for “CWD”).

Wyoming:

CWD was detected in several new hunts areas in the state of Wyoming during 2007 hunting seasons (Deer Hunt Areas 12, 23, 87, 122, 125 and 163; Elk Hunt Areas 13 and 110). Press releases from Wyoming Game and Fish Department documenting these new areas are at:

http://gf.state.wy.us/services/news/pressreleases/07/10/12/071012_1.asp

http://gf.state.wy.us/services/news/pressreleases/07/11/09/071109_2.asp

http://gf.state.wy.us/services/news/pressreleases/07/11/30/071130_2.asp

http://gf.state.wy.us/services/news/pressreleases/07/12/14/071214_3.asp

A summary of CWD detections in Wyoming (including a map of affected hunt areas, reproduced below) is available at:

http://gf.state.wy.us/downloads/pdf/CWDSummary12-11-07.pdf


Wyoming Game and Fish Department CWD information is at:

http://gf.state.wy.us/services/education/cwd/index.asp


Federal appropriations for CWD in FY2008: The “Consolidated Appropriations Act, 2008” was signed into law on December 26, 2007. Language from the USDA section of the “Joint Explanatory Statement” (http://www.rules.house.gov/110/text/omni/jes/jesdiva.pdf) accompanying the act includes the following: “The amended bill provides $17,807,000 for chronic wasting disease. Of this amount, $1,299,000 is for surveillance in Wisconsin; $183,000 is for surveillance in Utah; and $38,000 is for surveillance in Colorado.”

Recent Publications

Species barriers for chronic wasting disease by in vitro conversion of prion protein

Li Li, Michael B. Coulthart, Aru Balachandran, Avi Chakrabartty and Neil R. Cashman Biochemical and Biophysical Research Communications 364 (2007) 796–800.

Abstract:

Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy that can affect North American cervids (deer, elk, and moose). Using a novel in vitro conversion system based on incubation of prions with normal brain homogenates, we now report that PrPCWD of elk can readily induce the conversion of normal cervid PrP (PrPC) molecules to a protease-resistant form, but is less efficient in converting the PrPC of other species, such as human, bovine, hamster, and mouse. However, when substrate brain homogenates are partially denatured by acidic conditions (pH 3.5), PrPCWD-induced conversion can be greatly enhanced in all species. Our results demonstrate that PrPC from cervids (including moose) can be efficiently converted to a protease-resistant form by incubation with elk CWD prions, presumably due to sequence and structural similarities between these species. Moreover, partial denaturation of substrate PrPC can apparently overcome the structural barriers between more distant species

http://www.sciencedirect.com/science/journal/0006291X.

(Volume 364, Issue 4, pages 796-800).

Elk with a long incubation prion disease phenotype have a unique PrPd profile

Katherine I. O’Rourke, Terry R. Spraker, Dongyue Zhuanga, Justin J.Greenlee, Thomas E.Gidlewski and Amir N. Hamir

NeuroReport 18:1935-1938.

Abstract:

The transmissible spongiform encephalopathies (TSEs) invariably result in fatal neurodegeneration and accumulation of PrPd, an abnormal form of the host prion protein PrPc, encoded by the PRNP gene. A naturally occurring polymorphism (methionine/valine) at PRNP codon 129 is associated with variation in relative disease susceptibility, incubation time, clinical presentation, neuropathology, and/or PrPd biochemical characteristics in a range of human TSEs. A methionine/leucine polymorphism at the corresponding site in the Rocky Mountain elk PRNP gene is associated with variation in relative susceptibility and incubation time in the cervid TSE chronic wasting disease. We now report that elk lacking the predisposing 132-methionine allele develop chronic wasting disease after a long incubation period and display a novel PrPd folding pattern.

http://www.neuroreport.com/pt/re/neuroreport/abstract.00001756-200712030-00012.htm


Direct Detection of Soil-Bound Prions

Sacha Genovesi, Liviana Leita, Paolo Sequi, Igino Andrighetto, M. Catia Sorgato and Alessandro Bertoli

PLoS ONE 2(10): e1069. doi:10.1371/journal.pone.0001069.

Abstract:

Scrapie and chronic wasting disease are contagious prion diseases affecting sheep and cervids, respectively. Studies have indicated that horizontal transmission is important in sustaining these epidemics, and that environmental contamination plays an important role in this. In the perspective of detecting prions in soil samples from the field by more direct methods than animal-based bioassays, we have developed a novel immuno-based approach that visualises in situ the major component (PrPSc) of prions sorbed onto agricultural soil particles. Importantly, the protocol needs no extraction of the protein from soil. Using a cell-based assay of infectivity, we also report that samples of agricultural soil, or quartz sand, acquire prion infectivity after exposure to whole brain homogenates from prion-infected mice. Our data provide further support to the notion that prion-exposed soils retain infectivity, as recently determined in Syrian hamsters intracerebrally or orally challanged with contaminated soils. The cell approach of the potential infectivity of contaminated soil is faster and cheaper than classical animal-based bioassays. Although it suffers from limitations, e.g. it can currently test only a few mouse prion strains, the cell model can nevertheless be applied in its present form to understand how soil composition influences infectivity, and to test prion-inactivating procedures. Complete article is at:

http://www.plosone.org/article/info:doi/10.1371/journal.pone.0001069


Prion Strain Discrimination Using Luminescent Conjugated Polymers

Christina J Sigurdson, K Peter R Nilsson, Simone Hornemann, Giuseppe Manco, Magdalini Polymenidou, Petra Schwarz, Mario Leclerc, Per Hammarstrom, Kurt Wuthrich and Adriano Aguzzi

Nature Methods 4, 1023 - 1030 (01 Dec 2007).

Abstract:

The occurrence of multiple strains of prions may reflect conformational variability of PrPSc, a disease-associated, aggregated variant of the cellular prion protein, PrPC. Here we used luminescent conjugated polymers (LCPs), which emit conformation-dependent fluorescence spectra, for characterizing prion strains. LCP reactivity and emission spectra of brain sections discriminated among four immunohistochemically indistinguishable, serially mouse-passaged prion strains derived from sheep scrapie, chronic wasting disease (CWD), bovine spongiform encephalopathy (BSE), and mouse-adapted Rocky Mountain Laboratory scrapie prions. Furthermore, using LCPs we differentiated between field isolates of BSE and bovine amyloidotic spongiform encephalopathy, and identified noncongophilic deposits in prion-infected deer and sheep. We found that fibrils with distinct morphologies generated from chemically identical recombinant PrP yielded unique LCP spectra, suggesting that spectral characteristic differences resulted from distinct supramolecular PrP structures. LCPs may help to detect structural differences among discrete protein aggregates and to link protein conformational features with disease phenotypes.

http://www.nature.com/nmeth/journal/v4/n12/abs/nmeth1131.html


Landscape Genetics and the Spatial Distribution of Chronic Wasting Disease

Julie A. Blanchong, Michael D. Samuel, Kim T. Scribner, Byron V. Weckworth, Julia A. Langenberg and Kristine B. Filcek Biology Letters doi:10.1098/rsbl.2007.0523.

Abstract:

Predicting the spread of wildlife disease is critical for identifying populations at risk, targeting surveillance and designing proactive management programmes. We used a landscape genetics approach to identify landscape features that influenced gene flow and the distribution of chronic wasting disease (CWD) in Wisconsin white-tailed deer. CWD prevalence was negatively correlated with genetic differentiation of study area deer from deer in the area of disease origin (core-area). Genetic differentiation was greatest, and CWD prevalence lowest, in areas separated from the core-area by the Wisconsin River, indicating that this river reduced deer gene flow and probably disease spread. Features of the landscape that influence host dispersal and spatial patterns of disease can be identified based on host spatial genetic structure. Landscape genetics may be used to predict high-risk populations based on their genetic connection to infected populations and to target disease surveillance, control and preventative activities. Complete article is available at:

http://journals.royalsociety.org/content/44065255151h0704/fulltext.pdf


see full text ;

http://wildlifedisease.nbii.gov/documents/CWD%20Updates/Update%2089.pdf


UPDATED DATA ABOUT NEBRASKA CWD

Chronic wasting found in Hall County deer web-posted Friday, January 4, 2008

Chronic wasting found in Hall County deer

By Mark Coddington mark.coddington@theindependent.com

A deer in Hall County tested positive for chronic wasting disease this fall, the first documented case in the county since 2004.

The deer was one of 18 in the state found with the disease this year, out of 3,310 tested, said Bruce Trindle, the Nebraska Game and Parks Commission's big game research leader.

Just as in every year since the disease was first found in the state in 2000, most of the positive tests were in deer found in the Panhandle, Trindle said.

But this year's results included a few scattered occurrences outside that area, including one near Ogallala in Keith County, one south of McCook in Red Willow County and one south of Alda, almost 200 miles from the disease's "endemic" area.

Trindle said Game and Parks officials aren't sure how the diseased deer ended up in Hall County, but they'll be conducting more tests on the area's deer to see if more have the disease.

"We don't have a good explanation why it makes those big jumps," Trindle said.

Chronic wasting disease produces small lesions in the brains of infected deer and elk, causing emaciation and abnormal behavior such as poor coordination. It has never spread to humans or domestic livestock, but it is always fatal for the deer and elk that contract it.

The state's concentration of chronic wasting cases is still well shy of 1 percent, far short of the prevalence of cases in Wyoming and Colorado, which have at times topped 5 percent of the deer and elk population.

But the occurrence of the disease so far from its primary area in western Nebraska has officials concerned.

"The red flag for us is that it has spread," Trindle said. "There's a chance the disease has moved out of the Panhandle."

The case could have come as a result of a hunter who came back from a trip with a contaminated carcass and disposed of it in Hall County, he said.

It's also possible that an infected deer traveled all the way from the Panhandle, as sick deer will sometimes travel longer distances than healthy ones.

In Colorado and Wyoming, it took decades for the disease to spread slowly throughout the deer and elk population. Nebraska's totals have been steady, with positive tests usually numbering in the teens, with a high of 33 in 2004 (An elk has never tested positive in the state).

Scientists aren't sure about how the disease spreads, which makes it difficult to stop, Trindle said.

And unlike its cousin, bovine spongiform encephalopathy or mad cow disease it's occurring in wild animals that are tough to track, said Richard Nelson, a wildlife manager for the commission's District 4 in southwest Nebraska.

"You don't send deer to a clinic for a flu shot," Nelson said.

Hall County's positive test in 2004 came at the old Cornhusker Army Ammunition Plant north of Alda, Nelson said. Further testing over the next two years found no deer with the disease.

Though the disease has never been transmitted to humans, officials don't recommended eating meat from a deer that's sick with chronic wasting disease or anything else, for that matter.

Trindle and Nelson recommended that outdoorsmen be careful, especially while hunting in Wyoming, Colorado or the Panhandle, and don't shoot any sick-looking animal. If a deer they've shot might be sick, they should take it in to Game and Parks officials for testing.

In past years, hunters haven't responded to reports of the disease with alarm, judging from strong sales of deer hunting licenses, Trindle said. After all, diseased deer have been around at least as long as people have been hunting them.

"You run the risk when you hunt deer that you (might) contract those diseases," he said.

http://www.theindependent.com/stories/01042008/new_deerdisease04.shtml


Officials dart elk Project tests chronic wasting disease, new fertility drug

BY MILES BLUMHARDT MilesBlumhardt@coloradoan.com

ROCKY MOUNTAIHN NATIONAL PARK - Margaret Wild crouched behind a boulder, squinted down the rifle sight, then squeezed off a perfect shot in the hip that made the cow elk flinch before running off into the meadow.

Several minutes later, the elk's legs were as wobbly as a drunk's until finally the animal crumpled to the ground and lay motionless on the edge of Moraine Park.

"You never know how the elk will react,'' Wild said of the dart she just fired. "Sometimes it stings them and they run a ways; and other times they hardly feel a thing.

"But most times they don't go more than 100 yards.''

Wild isn't one of the sharpshooters that, under the park's recently announced Elk and Vegetation Management Plan, will take aim at reducing the burgeoning elk herd by 100 to 200 animals annually over the next 20 years to reduce the damage on aspen and willow.

Instead, she is a National Park Service veterinarian from Fort Collins who is helping lead a groundbreaking two-pronged study. One part of the project is to conduct, for the first time in free-ranging elk, live tests for chronic wasting disease, a fatal brain disease. Also, for the first time in free-ranging elk, the project will study the effectiveness of a multiyear fertility control drug.

As part of those projects, wildlife officials began Thursday to use tranquilizer guns to dart 120 cow (female) elk this month. As of today, they had darted 13 animals. Half of the 120 elk will receive the fertility drug GonaCon developed by Lowell Miller at the National Wildlife Research Center in Fort Collins.

The other half will receive placebos. Blood, saliva and fecal samples will be taken from the animals to help with several promising live CWD tests. Radio collars will be placed on all the animals so wildlife officials can track and kill them.

Each of the next three years, 40 of the cows - 20 given the fertility drug and 20 the placebo - will be killed and checked for pregnancy to determine the effectiveness of the drug.

"It would be a major breakthrough if we could find a live chronic wasting disease test,'' said Dan Baker, a Colorado State University research scientist leading the fertility study. "The end goal for the fertility study is to see how long the agent will work.''

Two four- to five-person teams started Thursday driving the roads around Moraine, Beaver Meadows and Horseshoe parks, looking for easy targets close to the roads. The crews darted and put radio collars on three animals Thursday.

On Friday, the crews had a much easier time. They darted 10 elk thanks to a herd of several hundred cow elk grazing next to the Moraine Park Road with some on the road licking salt from the asphalt as well as visitors' stopped vehicles.

"It can be very stressful on the animals if we make a shot and it's not in the proper place because it takes a while for them to go down,'' Baker said Friday. "It's very beneficial them being so close to the road today.''

Shooters don't like to take aim at animals much farther than 20 yards away.

Once the animal succumbs to the tranquilizer, the animals' eyes are covered and the crew begins taking samples and checking to see if the animal is pregnant. The animal's heart rate and breathing are monitored to reduce the risk of accidental death. Once the samples are taken and the radio collar attached, the animal is given a drug that reverses the effects of the tranquilizing drug. Then it is monitored for the next 48 hours to make sure it survives the stress of the capture.

"For the most part, we have no problems,'' Baker said. "We have never lost an elk to any of the drugs we're using.''

Wild said the slight risk and stress to the animals is well worth it, considering the benefits of the projects.

"It's very rare that you get an opportunity to do studies on numbers of elk like this in a protected area,'' she said. "It's something pretty fun to do when you get your elk and watch them walk away and you have the information you wanted.''

http://www.coloradoan.com/apps/pbcs.dll/article?AID=/20080107/NEWS01/801070329/1002/CUSTOMERSERVICE02


CHRONIC WASTING DISEASE

http://chronic-wasting-disease.blogspot.com/


http://chronic-wasting-disease.blogspot.com/2007/12/nebraska-cwd-tested-3400-deer-with-17.html


http://chronic-wasting-disease.blogspot.com/2007/12/five-additional-deer-test-positive-for.html


http://chronic-wasting-disease.blogspot.com/2007/11/cwd-spreading-to-new-hunt-areas-in.html


http://chronic-wasting-disease.blogspot.com/2007/11/species-barriers-for-chronic-wasting.html


http://chronic-wasting-disease.blogspot.com/2006/12/chronic-wasting-disease.html


BSE BASE MAD COW TESTING TEXAS, USA, AND CANADA, A REVIEW OF SORTS

http://madcowtesting.blogspot.com/


MADCOW USDA the untold story

http://madcowusda.blogspot.com/


BSE OIE USDA

http://madcowtesting.blogspot.com/2008/01/bse-oie-usda.html


CREUTZFELDT JAKOB DISEASE MAD COW BASE UPDATE USA

http://cjdmadcowbaseoct2007.blogspot.com/


SCRAPIE USA

http://scrapie-usa.blogspot.com/


NOR-98 ATYPICAL SCRAPIE CASES USA (5 cases documented in 5 different states in 2007)

http://nor-98.blogspot.com/


Transmissible Mink Encephalopathy TME

http://transmissible-mink-encephalopathy.blogspot.com/


SEAC 99th meeting on Friday 14th December 2007

http://seac992007.blogspot.com/


vCJD case study highlights blood transfusion risk

http://vcjdblood.blogspot.com/


vCJD transfusion-associated Fourth Case UK

http://vcjdtransfusion.blogspot.com/


risk factors for sporadic CJD

http://creutzfeldt-jakob-disease.blogspot.com/2008/01/risk-factors-for-sporadic-creutzfeldt.html


BSE (Mad Cow) Update: Do Reports of sCJD Clusters Matter?

snip... see full text ;

http://cjdtexas.blogspot.com/


[In submitting these data, Terry S. Singeltary Sr. draws attention to the steady increase in the "type unknown" category, which, according to their definition, comprises cases in which vCJD could be excluded. The total of 26 cases for the current year (2007) is disturbing, possibly symptomatic of the circulation of novel agents. Characterization of these agents should be given a high priority. - Mod.CP]

http://www.promedmail.org/pls/askus/f?p=2400:1001:6833194127530602005::NO::F2400_P1001_BACK_PAGE,F2400_P1001_PUB_MAIL_ID:1010,39963

There is a growing number of human CJD cases, and they were presented last week in San Francisco by Luigi Gambatti(?) from his CJD surveillance collection.

He estimates that it may be up to 14 or 15 persons which display selectively SPRPSC and practically no detected RPRPSC proteins.

http://www.fda.gov/ohrms/dockets/ac/06/transcripts/1006-4240t1.htm


http://www.fda.gov/ohrms/dockets/ac/06/transcripts/2006-4240t1.pdf


JOURNAL OF NEUROLOGY

MARCH 26, 2003

RE-Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob

disease in the United States

Email Terry S. Singeltary:

flounder@wt.net

I lost my mother to hvCJD (Heidenhain Variant CJD). I would like to

comment on the CDC's attempts to monitor the occurrence of emerging

forms of CJD. Asante, Collinge et al [1] have reported that BSE

transmission to the 129-methionine genotype can lead to an alternate

phenotype that is indistinguishable from type 2 PrPSc, the commonest

sporadic CJD. However, CJD and all human TSEs are not reportable

nationally. CJD and all human TSEs must be made reportable in every

state and internationally. I hope that the CDC does not continue to

expect us to still believe that the 85%+ of all CJD cases which are

sporadic are all spontaneous, without route/source. We have many TSEs in

the USA in both animal and man. CWD in deer/elk is spreading rapidly and

CWD does transmit to mink, ferret, cattle, and squirrel monkey by

intracerebral inoculation. With the known incubation periods in other

TSEs, oral transmission studies of CWD may take much longer. Every

victim/family of CJD/TSEs should be asked about route and source of this

agent. To prolong this will only spread the agent and needlessly expose

others. In light of the findings of Asante and Collinge et al, there

should be drastic measures to safeguard the medical and surgical arena

from sporadic CJDs and all human TSEs. I only ponder how many sporadic

CJDs in the USA are type 2 PrPSc?

http://www.neurology.org/cgi/eletters/60/2/176#535


Monitoring the occurrence of emerging forms of Creutzfeldt-Jakob disease in the United States

http://cjdusa.blogspot.com/


Creutzfeldt Jakob Disease

http://creutzfeldt-jakob-disease.blogspot.com/


CJD QUESTIONNAIRE

http://cjdquestionnaire.blogspot.com/


ANIMAL HEALTH REPORT 2006 (BSE h-BASE EVENT IN ALABAMA, Scrapie, and CWD)

http://animalhealthreport2006.blogspot.com/


I only ponder how many sporadic CJDs in the USA are type 2 PrPSc?

http://www.neurology.org/cgi/eletters/60/2/176#535


THE PATHOLOGICAL PROTEIN Hardcover, 304 pages plus photos and illustrations. ISBN 0-387-95508-9 June 2003 BY Philip Yam

CHAPTER 14 LAYING ODDS

Answering critics like Terry Singeltary, who feels that the U.S. under-counts CJD, Schonberger conceded that the current surveillance system has errors but stated that most of the errors will be confined to the older population.

http://www.thepathologicalprotein.com/


doi:10.1016/S1473-3099(03)00715-1Copyright © 2003 Published by Elsevier Ltd.

Newsdesk

Tracking spongiform encephalopathies in North America

Xavier Bosch

Available online 29 July 2003. Volume 3, Issue 8, August 2003, Page 463

"My name is Terry S Singeltary Sr, and I live in Bacliff, Texas. I lost my mom to hvCJD (Heidenhain variant CJD) and have been searching for answers ever since. What I have found is that we have not been told the truth. CWD in deer and elk is a small portion of a much bigger problem." ...

http://www.thelancet.com/journals/laninf/article/PIIS1473309903007151/fulltext


http://download.thelancet.com/pdfs/journals/1473-3099/PIIS1473309903007151.pdf


Diagnosis and Reporting of Creutzfeldt-Jakob Disease

Singeltary, Sr et al. JAMA.2001; 285: 733-734.

http://jama.ama-assn.org/http://www.neurology.org/cgi/eletters/60/2/176#535


Like lambs to the slaughter 31 March 2001 Debora MacKenzie Magazine issue 2284

FOUR years ago, Terry Singeltary watched his mother die horribly from a degenerative brain disease. Doctors told him it was Alzheimer's, but Singeltary was suspicious. The diagnosis didn't fit her violent symptoms, and he demanded an autopsy. It showed she had died of sporadic Creutzfeldt-Jakob disease. Most doctors believe that sCJD is caused by a prion protein deforming by chance into a killer. But Singeltary thinks otherwise. He is one of a number of campaigners who say that some sCJD, like the variant CJD related to BSE, is caused by eating meat from infected animals. Their suspicions have focused on sheep carrying scrapie, a BSE-like disease that is wide spread in flocks across Europe and North America. Now scientists in France have stumbled across new evidence that adds weight to the campaigners' fears. To their complete surprise, the researchers found that one strain of scrapie causes the same brain damage in mice as sCJD. "This means we cannot rule out that at least some sCJD may be caused by some strains of scrapie," says team member Jean-Philippe Deslys of the French Atomic Energy Commission's medical research laboratory in Fontenay-aux-Roses, south-west of Paris. Hans Kretschmar of the University of Göttingen, who coordinates CJD surveillance in Germany, is so concerned by the findings that he now wants to trawl back through past sCJD cases to see if any might have been caused by eating infected mutton or lamb. ...

http://www.newscientist.com/article/mg16922840.300-like-lambs-to-the-slaughter.html


DER SPIEGEL (9/2001) - 24.02.2001 (9397 Zeichen)USA: Loch in der MauerDie BSE-Angst erreicht Amerika: Trotz strikter Auflagen gelangte in Texasverbotenes Tiermehl ins Rinderfutter - die Kontrollen der Aufsichtsbehördensind lax. Link auf diesen Artikel im Archiv: http://service.spiegel.de/digas/find?DID=18578755"

Its as full of holes as Swiss Cheese" says Terry Singeltary of the FDA regulations. ...

http://service.spiegel.de/digas/servlet/find/DID=18578755


Thu Dec 6, 2007 11:38

FDA IN CRISIS MODE, AMERICAN LIVES AT RISK

http://www.cidrap.umn.edu/cidrap/content/fs/food-disease/news/dec0407fda.html


FDA SCIENCE AND MISSION AT RISK

http://www.fda.gov/ohrms/dockets/ac/07/briefing/2007-4329b_02_01_FDA%20Report%20on%20Science%20and%20Technology.pdf


2 January 2000 British Medical Journal

U.S. Scientist should be concerned with a CJD epidemic in the U.S., as well

http://www.bmj.com/cgi/eletters/320/7226/8/b#6117


15 November 1999 British Medical Journal

vCJD in the USA * BSE in U.S.

http://www.bmj.com/cgi/eletters/319/7220/1312/b#5406


TSS