CWD positive in western Frederick County VA VDGIF December 16, 2010
News Release For Immediate Release 12/16/2010 Contact Nelson Lafon, Deer Project Coordinator, 540-248-9295 Julia Dixon, Public Relations and Marketing Manager, 804-367-0991
VDGIF recognizes assistance of hunters, reports new CWD positive in western Frederick County
RICHMOND, VA- The Virginia Department of Game and Inland Fisheries (VDGIF) wishes to recognize the excellent cooperation of hunters in sampling for chronic wasting disease (CWD) in Frederick and Shenandoah counties this past November. To date, VDGIF has collected samples from more than 500 deer brought to check stations and self-service drop stations or killed on the road.
Unfortunately, but not unexpectedly, a new case of CWD was detected less than 2 miles from the first case discovered last year in western Frederick County, Virginia. The 4-year-old buck was killed by a hunter near the West Virginia line and brought to a check station for sampling on November 20, 2010. Given the proximity of this second case to the first one, changes to the current management actions or restrictions are not anticipated. However, VDGIF is still awaiting final test results from approximately 100 samples, so the need to modify management strategies cannot be determined until after the conclusion of the hunting season and receipt of all sample results in January.
We continue to encourage hunters who are successful during the remainder of the season to volunteer the head and neck from their deer for sampling by bringing it to one of our self-service refrigerated drop stations:
Frederick-Winchester Conservation Club, 527 Siler Road, Winchester (north of Gainesboro) Walker's Cash Store, 3321 Back Road, Woodstock (intersection with St. Luke Road) North Mountain Fire and Rescue, 186 Rosenberger Lane, Winchester (off Rt. 600, behind Tom’s Market). New Star Market, 2936 John Marshal Hwy, Strasburg (one mile west of I-81).
In addition to collecting samples, VDGIF has implemented several other management actions in the northern Shenandoah Valley during the past year in response to the detection of CWD. These management actions include: prohibiting the feeding of deer year-round, prohibiting the movement of deer carcasses and parts out of the Containment Area (with exceptions), restricting the disposal of deer wastes from the Containment Area, prohibiting the rehabilitation of deer in the Containment Area, and changing seasons and bag limits on private lands in an attempt to reduce the deer population.
CWD has been detected in 18 states and two Canadian provinces. CWD is a slow, progressive neurological (brain and nervous system) disease found in deer, elk, and moose in North America. The disease ultimately results in death of the infected animal. Symptoms exhibited by CWD-infected deer include, staggering, abnormal posture, lowered head, drooling, acting confused, and marked weight loss. There is no evidence that CWD can be naturally transmitted to humans, livestock, or pets. More information about CWD and these management actions can be found on the VDGIF website at www.dgif.virginia.gov/wildlife/diseases/cwd/.
http://www.dgif.virginia.gov/news/release.asp?id=275
http://www.dgif.virginia.gov/wildlife/diseases/cwd/
IN New York, it's believe that a Taxidermist brought in CWD ;
Those areas where infected carcasses or carcass parts may be found in quantity, such as taxidermy facilities, may act as foci where infection of live cervids may occur. Taxidermy operations were not noted in the CWD Plan, as they had not yet been identified as a potential source of infection.
A recent case in the state of New York had strong evidence that a CWD-positive animal living in an enclosure was linked to a taxidermy operation. Since there are no biosecurity protocols that can assure the destruction of the CWD agent, it is prudent to take steps to reduce the likelihood of live cervids interacting with potentially infected byproducts of taxidermy operations.
http://www.michigan.gov/documents/dnr/01-09_Taxidermy_Strike_INFO_2_1.21.09_264004_7.pdf
Investigations in New York indicate that the infection could have been spread by a taxidermist who accepted specimens from CWD-positive states, allowed rehabilitated fawns access to the taxidermy workshop and spread potentially infectious curing salt waste as a fence line weed killer on his deer farm.
http://www.portal.state.pa.us/portal/server.pt/document/716126/taxidermists_cwd_pdf
Wednesday, January 07, 2009
CWD to tighten taxidermy rules Hunters need to understand regulations
http://chronic-wasting-disease.blogspot.com/2009/01/cwd-to-tighten-taxidermy-rules-hunters.html
CWD, GAME FARMS, BAITING, AND POLITICS
http://chronic-wasting-disease.blogspot.com/2009/01/cwd-game-farms-baiting-and-politics.html
http://chronic-wasting-disease.blogspot.com/2008/08/cwd-feeding-and-baiting-piles.html
Monday, February 22, 2010
Aerosol and Nasal Transmission of Chronic Wasting Disease in Cervidized Mice
http://chronic-wasting-disease.blogspot.com/2010/02/aerosol-and-nasal-transmission-of.html
AS THE CROW FLIES, SO DOES CWD
Sunday, November 01, 2009
American crows (Corvus brachyrhynchos) and potential spreading of CWD through feces of digested infectious carcases
http://chronic-wasting-disease.blogspot.com/2009/11/american-crows-corvus-brachyrhynchos.html
Monday, July 13, 2009
Deer Carcass Decomposition and Potential Scavenger Exposure to Chronic Wasting Disease
http://chronic-wasting-disease.blogspot.com/2009/07/deer-carcass-decomposition-and.html
SO, as i said, once established, it is very difficult to extinguish completely. the trading of cervids from state to state (legal and illegal), is another problem. deer urine scents is another problem, you have hunters that pour this stuff on themselves, and it's just plain stupid, from what science is telling us.
Sunday, December 06, 2009
Detection of Sub-Clinical CWD Infection in Conventional Test-Negative Deer Long after Oral Exposure to Urine and Feces from CWD+ Deer
http://chronic-wasting-disease.blogspot.com/2009/12/detection-of-sub-clinical-cwd-infection.html
THEN YOU have water that has been contaminated from a CWD-endemic area ;
Wednesday, October 14, 2009
Detection of protease-resistant cervid prion protein in water from a CWD-endemic area
http://chronic-wasting-disease.blogspot.com/2009/10/detection-of-protease-resistant-cervid.html
ALSO, NOTE MINERAL LICKS A POSSIBLE SOURCE AND TRANSMISSION MODE FOR CWD ;
http://chronic-wasting-disease.blogspot.com/2009/08/third-international-cwd-symposium-july.html
http://www.cwd-info.org/pdf/3rd_CWD_Symposium_utah.pdf
UPDATED DATA ON 2ND CWD STRAIN
Wednesday, September 08, 2010
CWD PRION CONGRESS SEPTEMBER 8-11 2010
http://chronic-wasting-disease.blogspot.com/2010/09/cwd-prion-2010.html
PRION 2010 Meeting Report International Prion Congress: From agent to disease; September 8–11, 2010; Salzburg, Austria Volume 4, Issue 3 July/August/September 2010
http://www.landesbioscience.com/journals/prion/article/12764/
THIS FDA recall for CWD positive product in commerce, was NOT done for the welfare of the dead CWD postive elk. ...TSS
Wednesday, March 18, 2009
Noah's Ark Holding, LLC, Dawson, MN RECALL Elk products contain meat derived from an elk confirmed to have CWD NV, CA, TX, CO, NY, UT, FL, OK RECALLS AND FIELD CORRECTIONS: FOODS CLASS II
RECALLS AND FIELD CORRECTIONS: FOODS CLASS II
___________________________________
PRODUCT a) Elk Meat, Elk Tenderloin, Frozen in plastic vacuum packaging. Each package is approximately 2 lbs., and each case is approximately 16 lbs.; Item number 755125, Recall # F-129-9;
b) Elk Meat, Elk Trim, Frozen; Item number 755155, Recall # F-130-9;
c) Elk Meat, French Rack, Chilled. Item number 755132, Recall # F-131-9;
d) Elk Meat, Nude Denver Leg. Item number 755122, Recall # F-132-9;
e) Elk Meat, New York Strip Steak, Chilled. Item number 755128, Recall # F-133-9;
f) Elk Meat, Flank Steak Frozen. Item number 755131, Recall # F-134-9; CODE Elk Meats with production dates of December 29, 30, and 31
RECALLING FIRM/MANUFACTURER
Recalling Firm: Sierra Meats, Reno, NV, by telephone on January 29, 2009 and press release on February 9, 2009. Manufacturer: Noah’s Ark Holding, LLC, Dawson, MN. Firm initiated recall is ongoing.
REASON
Elk products contain meat derived from an elk confirmed to have Chronic Wasting Disease (CWD).
VOLUME OF PRODUCT IN COMMERCE Unknown
DISTRIBUTION NV, CA, TX, CO, NY, UT, FL, OK
http://www.fda.gov/Safety/Recalls/EnforcementReports/ucm154840.htm
Sunday, April 12, 2009
CWD UPDATE Infection Studies in Two Species of Non-Human Primates and one Environmental reservoir infectivity study and evidence of two strains
snip...
From: TSS (216-119-163-189.ipset45.wt.net)
Subject: CWD aka MAD DEER/ELK TO HUMANS ???
Date: September 30, 2002 at 7:06 am PST
From: "Belay, Ermias"
To:
Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias"
Sent: Monday, September 30, 2002 9:22 AM
Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Dear Sir/Madam, In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD.
That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.
Ermias Belay, M.D. Centers for Disease Control and Prevention
-----Original Message-----
From:
Sent: Sunday, September 29, 2002 10:15 AM
To: [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask]
Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS
snip...
full text ;
http://chronic-wasting-disease.blogspot.com/2009/02/exotic-meats-usa-announces-urgent.html
http://chronic-wasting-disease.blogspot.com/2009/03/noahs-ark-holding-llc-dawson-mn-recall.html
see full text ;
http://chronic-wasting-disease.blogspot.com/2009/04/cwd-update-infection-studies-in-two.html
Tuesday, February 09, 2010
Chronic Wasting Disease: Surveillance Update North America: February 2010
>>> In addition, we documented horizontal transmission of CWD from inoculated mice and to un-inoculated cohabitant cage-mates. <<<
http://ajp.amjpathol.org/cgi/content/abstract/ajpath.2010.090710v1
http://chronic-wasting-disease.blogspot.com/2010/02/chronic-wasting-disease-surveillance.html
Wednesday, November 17, 2010
CWD Update 98 November 10, 2010
http://chronic-wasting-disease.blogspot.com/2010/11/cwd-update-98-november-10-2010.html
http://chronic-wasting-disease.blogspot.com/
Saturday, December 11, 2010
Species-barrier-independent prion replication in apparently resistant species
http://transmissiblespongiformencephalopathy.blogspot.com/2010/12/species-barrier-independent-prion.html
There are now two documented strains of CWD, and science is showing that indeed CWD could transmit to humans via transmission studies ;
PPo3-7:
Prion Transmission from Cervids to Humans is Strain-dependent
Qingzhong Kong, Shenghai Huang,*Fusong Chen, Michael Payne, Pierluigi Gambetti and Liuting Qing Department of Pathology; Case western Reserve University; Cleveland, OH USA *Current address: Nursing Informatics; Memorial Sloan-Kettering Cancer Center; New York, NY USA
Key words: CWD, strain, human transmission
Chronic wasting disease (CWD) is a widespread prion disease in cervids (deer and elk) in North America where significant human exposure to CWD is likely and zoonotic transmission of CWD is a concern. Current evidence indicates a strong barrier for transmission of the classical CWD strain to humans with the PrP-129MM genotype. A few recent reports suggest the presence of two or more CWD strains. What remain unknown is whether individuals with the PrP-129VV/MV genotypes are also resistant to the classical CWD strain and whether humans are resistant to all natural or adapted cervid prion strains. Here we report that a human prion strain that had adopted the cervid prion protein (PrP) sequence through passage in cervidized transgenic mice efficiently infected transgenic mice expressing human PrP, indicating that the species barrier from cervid to humans is prion strain-dependent and humans can be vulnerable to novel cervid prion strains. Preliminary results on CWD transmission in transgenic mice expressing human PrP-129V will also be discussed.
Acknowledgement Supported by NINDS NS052319 and NIA AG14359.
PPo2-27:
Generation of a Novel form of Human PrPSc by Inter-species Transmission of Cervid Prions
Marcelo A. Barria,1 Glenn C. Telling,2 Pierluigi Gambetti,3 James A. Mastrianni4 and Claudio Soto1 1Mitchell Center for Alzheimer's disease and related Brain disorders; Dept of Neurology; University of Texas Houston Medical School; Houston, TX USA; 2Dept of Microbiology, Immunology & Molecular Genetics and Neurology; Sanders Brown Center on Aging; University of Kentucky Medical Center; Lexington, KY USA; 3Institute of Pathology; Case western Reserve University; Cleveland, OH USA; 4Dept of Neurology; University of Chicago; Chicago, IL USA
Prion diseases are infectious neurodegenerative disorders affecting humans and animals that result from the conversion of normal prion protein (PrPC) into the misfolded and infectious prion (PrPSc). Chronic wasting disease (CWD) of cervids is a prion disorder of increasing prevalence within the United States that affects a large population of wild and captive deer and elk. CWD is highly contagious and its origin, mechanism of transmission and exact prevalence are currently unclear. The risk of transmission of CWD to humans is unknown. Defining that risk is of utmost importance, considering that people have been infected by animal prions, resulting in new fatal diseases. To study the possibility that human PrPC can be converted into the infectious form by CWD PrPSc we performed experiments using the Protein Misfolding Cyclic Amplification (PMCA) technique, which mimic in vitro the process of prion replication. Our results show that cervid PrPSc can induce the pathological conversion of human PrPC, but only after the CWD prion strain has been stabilized by successive passages in vitro or in vivo. Interestingly, this newly generated human PrPSc exhibits a distinct biochemical pattern that differs from any of the currently known forms of human PrPSc, indicating that it corresponds to a novel human prion strain. Our findings suggest that CWD prions have the capability to infect humans, and that this ability depends on CWD strain adaptation, implying that the risk for human health progressively increases with the spread of CWD among cervids.
PPo2-7:
Biochemical and Biophysical Characterization of Different CWD Isolates
Martin L. Daus and Michael Beekes Robert Koch Institute; Berlin, Germany
Key words: CWD, strains, FT-IR, AFM
Chronic wasting disease (CWD) is one of three naturally occurring forms of prion disease. The other two are Creutzfeldt-Jakob disease in humans and scrapie in sheep. CWD is contagious and affects captive as well as free ranging cervids. As long as there is no definite answer of whether CWD can breach the species barrier to humans precautionary measures especially for the protection of consumers need to be considered. In principle, different strains of CWD may be associated with different risks of transmission to humans. Sophisticated strain differentiation as accomplished for other prion diseases has not yet been established for CWD. However, several different findings indicate that there exists more than one strain of CWD agent in cervids. We have analysed a set of CWD isolates from white-tailed deer and could detect at least two biochemically different forms of disease-associated prion protein PrPTSE. Limited proteolysis with different concentrations of proteinase K and/or after exposure of PrPTSE to different pH-values or concentrations of Guanidinium hydrochloride resulted in distinct isolate-specific digestion patterns. Our CWD isolates were also examined in protein misfolding cyclic amplification studies. This showed different conversion activities for those isolates that had displayed significantly different sensitivities to limited proteolysis by PK in the biochemical experiments described above. We further applied Fourier transform infrared spectroscopy in combination with atomic force microscopy. This confirmed structural differences in the PrPTSE of at least two disinct CWD isolates. The data presented here substantiate and expand previous reports on the existence of different CWD strains.
http://www.prion2010.org/bilder/prion_2010_program_latest_w_posters_4_.pdf?139&PHPSESSID=a30a38202cfec579000b77af81be3099
TSS
VDGIF recognizes assistance of hunters, reports new CWD positive in western Frederick County
RICHMOND, VA- The Virginia Department of Game and Inland Fisheries (VDGIF) wishes to recognize the excellent cooperation of hunters in sampling for chronic wasting disease (CWD) in Frederick and Shenandoah counties this past November. To date, VDGIF has collected samples from more than 500 deer brought to check stations and self-service drop stations or killed on the road.
Unfortunately, but not unexpectedly, a new case of CWD was detected less than 2 miles from the first case discovered last year in western Frederick County, Virginia. The 4-year-old buck was killed by a hunter near the West Virginia line and brought to a check station for sampling on November 20, 2010. Given the proximity of this second case to the first one, changes to the current management actions or restrictions are not anticipated. However, VDGIF is still awaiting final test results from approximately 100 samples, so the need to modify management strategies cannot be determined until after the conclusion of the hunting season and receipt of all sample results in January.
We continue to encourage hunters who are successful during the remainder of the season to volunteer the head and neck from their deer for sampling by bringing it to one of our self-service refrigerated drop stations:
Frederick-Winchester Conservation Club, 527 Siler Road, Winchester (north of Gainesboro) Walker's Cash Store, 3321 Back Road, Woodstock (intersection with St. Luke Road) North Mountain Fire and Rescue, 186 Rosenberger Lane, Winchester (off Rt. 600, behind Tom’s Market). New Star Market, 2936 John Marshal Hwy, Strasburg (one mile west of I-81).
In addition to collecting samples, VDGIF has implemented several other management actions in the northern Shenandoah Valley during the past year in response to the detection of CWD. These management actions include: prohibiting the feeding of deer year-round, prohibiting the movement of deer carcasses and parts out of the Containment Area (with exceptions), restricting the disposal of deer wastes from the Containment Area, prohibiting the rehabilitation of deer in the Containment Area, and changing seasons and bag limits on private lands in an attempt to reduce the deer population.
CWD has been detected in 18 states and two Canadian provinces. CWD is a slow, progressive neurological (brain and nervous system) disease found in deer, elk, and moose in North America. The disease ultimately results in death of the infected animal. Symptoms exhibited by CWD-infected deer include, staggering, abnormal posture, lowered head, drooling, acting confused, and marked weight loss. There is no evidence that CWD can be naturally transmitted to humans, livestock, or pets. More information about CWD and these management actions can be found on the VDGIF website at www.dgif.virginia.gov/wildlife/diseases/cwd/.
http://www.dgif.virginia.gov/news/release.asp?id=275
http://www.dgif.virginia.gov/wildlife/diseases/cwd/
IN New York, it's believe that a Taxidermist brought in CWD ;
Those areas where infected carcasses or carcass parts may be found in quantity, such as taxidermy facilities, may act as foci where infection of live cervids may occur. Taxidermy operations were not noted in the CWD Plan, as they had not yet been identified as a potential source of infection.
A recent case in the state of New York had strong evidence that a CWD-positive animal living in an enclosure was linked to a taxidermy operation. Since there are no biosecurity protocols that can assure the destruction of the CWD agent, it is prudent to take steps to reduce the likelihood of live cervids interacting with potentially infected byproducts of taxidermy operations.
http://www.michigan.gov/documents/dnr/01-09_Taxidermy_Strike_INFO_2_1.21.09_264004_7.pdf
Investigations in New York indicate that the infection could have been spread by a taxidermist who accepted specimens from CWD-positive states, allowed rehabilitated fawns access to the taxidermy workshop and spread potentially infectious curing salt waste as a fence line weed killer on his deer farm.
http://www.portal.state.pa.us/portal/server.pt/document/716126/taxidermists_cwd_pdf
Wednesday, January 07, 2009
CWD to tighten taxidermy rules Hunters need to understand regulations
http://chronic-wasting-disease.blogspot.com/2009/01/cwd-to-tighten-taxidermy-rules-hunters.html
CWD, GAME FARMS, BAITING, AND POLITICS
http://chronic-wasting-disease.blogspot.com/2009/01/cwd-game-farms-baiting-and-politics.html
http://chronic-wasting-disease.blogspot.com/2008/08/cwd-feeding-and-baiting-piles.html
Monday, February 22, 2010
Aerosol and Nasal Transmission of Chronic Wasting Disease in Cervidized Mice
http://chronic-wasting-disease.blogspot.com/2010/02/aerosol-and-nasal-transmission-of.html
AS THE CROW FLIES, SO DOES CWD
Sunday, November 01, 2009
American crows (Corvus brachyrhynchos) and potential spreading of CWD through feces of digested infectious carcases
http://chronic-wasting-disease.blogspot.com/2009/11/american-crows-corvus-brachyrhynchos.html
Monday, July 13, 2009
Deer Carcass Decomposition and Potential Scavenger Exposure to Chronic Wasting Disease
http://chronic-wasting-disease.blogspot.com/2009/07/deer-carcass-decomposition-and.html
SO, as i said, once established, it is very difficult to extinguish completely. the trading of cervids from state to state (legal and illegal), is another problem. deer urine scents is another problem, you have hunters that pour this stuff on themselves, and it's just plain stupid, from what science is telling us.
Sunday, December 06, 2009
Detection of Sub-Clinical CWD Infection in Conventional Test-Negative Deer Long after Oral Exposure to Urine and Feces from CWD+ Deer
http://chronic-wasting-disease.blogspot.com/2009/12/detection-of-sub-clinical-cwd-infection.html
THEN YOU have water that has been contaminated from a CWD-endemic area ;
Wednesday, October 14, 2009
Detection of protease-resistant cervid prion protein in water from a CWD-endemic area
http://chronic-wasting-disease.blogspot.com/2009/10/detection-of-protease-resistant-cervid.html
ALSO, NOTE MINERAL LICKS A POSSIBLE SOURCE AND TRANSMISSION MODE FOR CWD ;
http://chronic-wasting-disease.blogspot.com/2009/08/third-international-cwd-symposium-july.html
http://www.cwd-info.org/pdf/3rd_CWD_Symposium_utah.pdf
UPDATED DATA ON 2ND CWD STRAIN
Wednesday, September 08, 2010
CWD PRION CONGRESS SEPTEMBER 8-11 2010
http://chronic-wasting-disease.blogspot.com/2010/09/cwd-prion-2010.html
PRION 2010 Meeting Report International Prion Congress: From agent to disease; September 8–11, 2010; Salzburg, Austria Volume 4, Issue 3 July/August/September 2010
http://www.landesbioscience.com/journals/prion/article/12764/
THIS FDA recall for CWD positive product in commerce, was NOT done for the welfare of the dead CWD postive elk. ...TSS
Wednesday, March 18, 2009
Noah's Ark Holding, LLC, Dawson, MN RECALL Elk products contain meat derived from an elk confirmed to have CWD NV, CA, TX, CO, NY, UT, FL, OK RECALLS AND FIELD CORRECTIONS: FOODS CLASS II
RECALLS AND FIELD CORRECTIONS: FOODS CLASS II
___________________________________
PRODUCT a) Elk Meat, Elk Tenderloin, Frozen in plastic vacuum packaging. Each package is approximately 2 lbs., and each case is approximately 16 lbs.; Item number 755125, Recall # F-129-9;
b) Elk Meat, Elk Trim, Frozen; Item number 755155, Recall # F-130-9;
c) Elk Meat, French Rack, Chilled. Item number 755132, Recall # F-131-9;
d) Elk Meat, Nude Denver Leg. Item number 755122, Recall # F-132-9;
e) Elk Meat, New York Strip Steak, Chilled. Item number 755128, Recall # F-133-9;
f) Elk Meat, Flank Steak Frozen. Item number 755131, Recall # F-134-9; CODE Elk Meats with production dates of December 29, 30, and 31
RECALLING FIRM/MANUFACTURER
Recalling Firm: Sierra Meats, Reno, NV, by telephone on January 29, 2009 and press release on February 9, 2009. Manufacturer: Noah’s Ark Holding, LLC, Dawson, MN. Firm initiated recall is ongoing.
REASON
Elk products contain meat derived from an elk confirmed to have Chronic Wasting Disease (CWD).
VOLUME OF PRODUCT IN COMMERCE Unknown
DISTRIBUTION NV, CA, TX, CO, NY, UT, FL, OK
http://www.fda.gov/Safety/Recalls/EnforcementReports/ucm154840.htm
Sunday, April 12, 2009
CWD UPDATE Infection Studies in Two Species of Non-Human Primates and one Environmental reservoir infectivity study and evidence of two strains
snip...
From: TSS (216-119-163-189.ipset45.wt.net)
Subject: CWD aka MAD DEER/ELK TO HUMANS ???
Date: September 30, 2002 at 7:06 am PST
From: "Belay, Ermias"
To:
Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias"
Sent: Monday, September 30, 2002 9:22 AM
Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Dear Sir/Madam, In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD.
That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.
Ermias Belay, M.D. Centers for Disease Control and Prevention
-----Original Message-----
From:
Sent: Sunday, September 29, 2002 10:15 AM
To: [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask]; [log in to unmask]">[log in to unmask]
Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS
snip...
full text ;
http://chronic-wasting-disease.blogspot.com/2009/02/exotic-meats-usa-announces-urgent.html
http://chronic-wasting-disease.blogspot.com/2009/03/noahs-ark-holding-llc-dawson-mn-recall.html
see full text ;
http://chronic-wasting-disease.blogspot.com/2009/04/cwd-update-infection-studies-in-two.html
Tuesday, February 09, 2010
Chronic Wasting Disease: Surveillance Update North America: February 2010
>>> In addition, we documented horizontal transmission of CWD from inoculated mice and to un-inoculated cohabitant cage-mates. <<<
http://ajp.amjpathol.org/cgi/content/abstract/ajpath.2010.090710v1
http://chronic-wasting-disease.blogspot.com/2010/02/chronic-wasting-disease-surveillance.html
Wednesday, November 17, 2010
CWD Update 98 November 10, 2010
http://chronic-wasting-disease.blogspot.com/2010/11/cwd-update-98-november-10-2010.html
http://chronic-wasting-disease.blogspot.com/
Saturday, December 11, 2010
Species-barrier-independent prion replication in apparently resistant species
http://transmissiblespongiformencephalopathy.blogspot.com/2010/12/species-barrier-independent-prion.html
There are now two documented strains of CWD, and science is showing that indeed CWD could transmit to humans via transmission studies ;
PPo3-7:
Prion Transmission from Cervids to Humans is Strain-dependent
Qingzhong Kong, Shenghai Huang,*Fusong Chen, Michael Payne, Pierluigi Gambetti and Liuting Qing Department of Pathology; Case western Reserve University; Cleveland, OH USA *Current address: Nursing Informatics; Memorial Sloan-Kettering Cancer Center; New York, NY USA
Key words: CWD, strain, human transmission
Chronic wasting disease (CWD) is a widespread prion disease in cervids (deer and elk) in North America where significant human exposure to CWD is likely and zoonotic transmission of CWD is a concern. Current evidence indicates a strong barrier for transmission of the classical CWD strain to humans with the PrP-129MM genotype. A few recent reports suggest the presence of two or more CWD strains. What remain unknown is whether individuals with the PrP-129VV/MV genotypes are also resistant to the classical CWD strain and whether humans are resistant to all natural or adapted cervid prion strains. Here we report that a human prion strain that had adopted the cervid prion protein (PrP) sequence through passage in cervidized transgenic mice efficiently infected transgenic mice expressing human PrP, indicating that the species barrier from cervid to humans is prion strain-dependent and humans can be vulnerable to novel cervid prion strains. Preliminary results on CWD transmission in transgenic mice expressing human PrP-129V will also be discussed.
Acknowledgement Supported by NINDS NS052319 and NIA AG14359.
PPo2-27:
Generation of a Novel form of Human PrPSc by Inter-species Transmission of Cervid Prions
Marcelo A. Barria,1 Glenn C. Telling,2 Pierluigi Gambetti,3 James A. Mastrianni4 and Claudio Soto1 1Mitchell Center for Alzheimer's disease and related Brain disorders; Dept of Neurology; University of Texas Houston Medical School; Houston, TX USA; 2Dept of Microbiology, Immunology & Molecular Genetics and Neurology; Sanders Brown Center on Aging; University of Kentucky Medical Center; Lexington, KY USA; 3Institute of Pathology; Case western Reserve University; Cleveland, OH USA; 4Dept of Neurology; University of Chicago; Chicago, IL USA
Prion diseases are infectious neurodegenerative disorders affecting humans and animals that result from the conversion of normal prion protein (PrPC) into the misfolded and infectious prion (PrPSc). Chronic wasting disease (CWD) of cervids is a prion disorder of increasing prevalence within the United States that affects a large population of wild and captive deer and elk. CWD is highly contagious and its origin, mechanism of transmission and exact prevalence are currently unclear. The risk of transmission of CWD to humans is unknown. Defining that risk is of utmost importance, considering that people have been infected by animal prions, resulting in new fatal diseases. To study the possibility that human PrPC can be converted into the infectious form by CWD PrPSc we performed experiments using the Protein Misfolding Cyclic Amplification (PMCA) technique, which mimic in vitro the process of prion replication. Our results show that cervid PrPSc can induce the pathological conversion of human PrPC, but only after the CWD prion strain has been stabilized by successive passages in vitro or in vivo. Interestingly, this newly generated human PrPSc exhibits a distinct biochemical pattern that differs from any of the currently known forms of human PrPSc, indicating that it corresponds to a novel human prion strain. Our findings suggest that CWD prions have the capability to infect humans, and that this ability depends on CWD strain adaptation, implying that the risk for human health progressively increases with the spread of CWD among cervids.
PPo2-7:
Biochemical and Biophysical Characterization of Different CWD Isolates
Martin L. Daus and Michael Beekes Robert Koch Institute; Berlin, Germany
Key words: CWD, strains, FT-IR, AFM
Chronic wasting disease (CWD) is one of three naturally occurring forms of prion disease. The other two are Creutzfeldt-Jakob disease in humans and scrapie in sheep. CWD is contagious and affects captive as well as free ranging cervids. As long as there is no definite answer of whether CWD can breach the species barrier to humans precautionary measures especially for the protection of consumers need to be considered. In principle, different strains of CWD may be associated with different risks of transmission to humans. Sophisticated strain differentiation as accomplished for other prion diseases has not yet been established for CWD. However, several different findings indicate that there exists more than one strain of CWD agent in cervids. We have analysed a set of CWD isolates from white-tailed deer and could detect at least two biochemically different forms of disease-associated prion protein PrPTSE. Limited proteolysis with different concentrations of proteinase K and/or after exposure of PrPTSE to different pH-values or concentrations of Guanidinium hydrochloride resulted in distinct isolate-specific digestion patterns. Our CWD isolates were also examined in protein misfolding cyclic amplification studies. This showed different conversion activities for those isolates that had displayed significantly different sensitivities to limited proteolysis by PK in the biochemical experiments described above. We further applied Fourier transform infrared spectroscopy in combination with atomic force microscopy. This confirmed structural differences in the PrPTSE of at least two disinct CWD isolates. The data presented here substantiate and expand previous reports on the existence of different CWD strains.
http://www.prion2010.org/bilder/prion_2010_program_latest_w_posters_4_.pdf?139&PHPSESSID=a30a38202cfec579000b77af81be3099
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